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学科主题: 临床医学
题名:
Chronic GVHD induced GVL effect after unmanipulated haploidentical hematopoietic SCT for AML and myelodysplastic syndrome
作者: Mo, X-D1; Xu, L-P1; Zhang, X-H1; Liu, D-H1; Wang, Y.1; Chen, H.1; Yan, C-H1; Chen, Y-H1; Han, W.1; Wang, F-R1; Wang, J-Z1; Liu, K-Y1; Huang, X-J1,2
刊名: BONE MARROW TRANSPLANTATION
发表日期: 2015
DOI: 10.1038/bmt.2014.223
卷: 50, 期:1, 页:127-133
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
研究领域[WOS]: Biophysics ; Oncology ; Hematology ; Immunology ; Transplantation
关键词[WOS]: VERSUS-HOST-DISEASE ; STEM-CELL TRANSPLANTATION ; BONE-MARROW-TRANSPLANTATION ; HLA-MISMATCHED/HAPLOIDENTICAL BLOOD ; NIH CONSENSUS CRITERIA ; ACUTE MYELOID-LEUKEMIA ; CHRONIC GRAFT ; HEMATOLOGIC MALIGNANCIES ; POSTTRANSPLANTATION CYCLOPHOSPHAMIDE ; COMORBIDITY INDEX
英文摘要:

The aim of this study was to investigate the impact of occurrence of chronic GVHD (cGVHD) and its severity on transplantation outcomes in a consecutive cohort of AML and myelodysplastic syndrome (MDS) patients who received unmanipulated haploidentical hematopoietic SCT (haplo-HSCT; n = 324). The cumulative incidence of relapse was significantly decreased in patients with cGVHD compared with the non-cGVHD group (1 year: 3.2% vs 11.9%, P = 0.002; 3 years: 6.0% vs 16.3%, P = 0.002), particularly in those with mild cGVHD. The cumulative incidence of non-relapse mortality was comparable between patients with and without cGVHD. The probabilities of disease-free survival (DFS) were significantly better in patients with cGVHD than in those in the non-cGVHD group (1 year: 90.5% vs 78.5%, P = 0.002; 3 years: 86.5% vs 71.5%, P < 0.001), particularly in those with mild or moderate cGVHD; however, no significant impact of severe cGVHD on DFS was seen. Our findings highlight the close relationship between cGVHD and the immune-mediated GVL effect in patients with AML and MDS receiving unmanipulated haplo-HSCT; however, only mild or moderate cGVHD was associated with a lower risk of relapse translating into improved DFS.

语种: 英语
所属项目编号: Z111107067311070 ; Z121107001012085 ; 81230013
项目资助者: Beijing Municipal Science and Technology Program ; Clinical Characteristic Study of Capital Project ; Key Program of the National Natural Science Foundation of China
WOS记录号: WOS:000347806800022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66020
Appears in Collections:北京大学第二临床医学院_血液科_期刊论文

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作者单位: 1.Peking Tsinghua Ctr Life Sci, Beijing, Peoples R China
2.Peking Univ, Inst Hematol, Peoples Hosp, Beijing 100044, Peoples R China

Recommended Citation:
Mo, X-D,Xu, L-P,Zhang, X-H,et al. Chronic GVHD induced GVL effect after unmanipulated haploidentical hematopoietic SCT for AML and myelodysplastic syndrome[J]. BONE MARROW TRANSPLANTATION,2015,50(1):127-133.
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