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学科主题: 药学
题名:
Ilexpublesnins C-M, Eleven New Triterpene Saponins from the Roots of Ilex pubescens
作者: Zhou, Yuan1; Chai, Xing-Yun2; Zeng, Ke-Wu1; Zhang, Jia-Yu1; Li, Ning1; Jiang, Yong1; Tu, Peng-Fei1,2
关键词: Ilex pubescens ; Aquifoliaceae ; ilexpublesnins C-M ; triterpene saponin ; 24-aldehyde group ; cytotoxicity
刊名: PLANTA MEDICA
发表日期: 2013
DOI: 10.1055/s-0032-1327927
卷: 79, 期:1, 页:70-77
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]: NMR SPECTROSCOPIC DATA ; COMPLETE ASSIGNMENTS ; LEAVES ; GLYCOSIDES ; PERNYI ; HAINANENSIS ; KUDINGCHA ; LIGNAN ; H-1
英文摘要:

Eleven new triterpene saponins, ilexpublesnins C-M (1-11), along with ten known analogues were isolated from the roots of Ilex pubescens. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 1, 2, 10, and 11 contain a 24-aldehyde, which is rare for triterpene saponins from Ilex. These compounds were evaluated in vitro for their cytotoxic effects on human cancer cell lines HepG2, HLE, BEL7402, BEL7403, BEL7405, MCF-7, and HeLa. Among them, only compounds 6 and 19 showed cytotoxicity against the MCF-7 cell line [inhibition (%): 33.14 and 34.03, respectively].

语种: 英语
所属项目编号: 30672608 ; 2009ZX09311-004
项目资助者: Natural Science Foundation of China ; scientific and technological major special project for &prime ; Significant Creation of New Drugs&prime
WOS记录号: WOS:000313055500012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66021
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing, Peoples R China

Recommended Citation:
Zhou, Yuan,Chai, Xing-Yun,Zeng, Ke-Wu,et al. Ilexpublesnins C-M, Eleven New Triterpene Saponins from the Roots of Ilex pubescens[J]. PLANTA MEDICA,2013,79(1):70-77.
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