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Ilexpublesnins C-M, Eleven New Triterpene Saponins from the Roots of Ilex pubescens
Zhou, Yuan1; Chai, Xing-Yun2; Zeng, Ke-Wu1; Zhang, Jia-Yu1; Li, Ning1; Jiang, Yong1; Tu, Peng-Fei1,2
关键词Ilex pubescens Aquifoliaceae ilexpublesnins C-M triterpene saponin 24-aldehyde group cytotoxicity
刊名PLANTA MEDICA
2013
DOI10.1055/s-0032-1327927
79期:1页:70-77
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Plant Sciences ; Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Plant Sciences ; Pharmacology & Pharmacy
关键词[WOS]NMR SPECTROSCOPIC DATA ; COMPLETE ASSIGNMENTS ; LEAVES ; GLYCOSIDES ; PERNYI ; HAINANENSIS ; KUDINGCHA ; LIGNAN ; H-1
英文摘要

Eleven new triterpene saponins, ilexpublesnins C-M (1-11), along with ten known analogues were isolated from the roots of Ilex pubescens. Their structures were elucidated on the basis of extensive spectroscopic analysis, including 1D and 2D NMR experiments. Compounds 1, 2, 10, and 11 contain a 24-aldehyde, which is rare for triterpene saponins from Ilex. These compounds were evaluated in vitro for their cytotoxic effects on human cancer cell lines HepG2, HLE, BEL7402, BEL7403, BEL7405, MCF-7, and HeLa. Among them, only compounds 6 and 19 showed cytotoxicity against the MCF-7 cell line [inhibition (%): 33.14 and 34.03, respectively].

语种英语
WOS记录号WOS:000313055500012
项目编号30672608 ; 2009ZX09311-004
资助机构Natural Science Foundation of China ; scientific and technological major special project for &prime ; Significant Creation of New Drugs&prime
引用统计
被引频次:17[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66021
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位1.Peking Univ, Hlth Sci Ctr, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Beijing Univ Chinese Med, Modern Res Ctr Tradit Chinese Med, Beijing, Peoples R China
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GB/T 7714
Zhou, Yuan,Chai, Xing-Yun,Zeng, Ke-Wu,et al. Ilexpublesnins C-M, Eleven New Triterpene Saponins from the Roots of Ilex pubescens[J]. PLANTA MEDICA,2013,79(1):70-77.
APA Zhou, Yuan.,Chai, Xing-Yun.,Zeng, Ke-Wu.,Zhang, Jia-Yu.,Li, Ning.,...&Tu, Peng-Fei.(2013).Ilexpublesnins C-M, Eleven New Triterpene Saponins from the Roots of Ilex pubescens.PLANTA MEDICA,79(1),70-77.
MLA Zhou, Yuan,et al."Ilexpublesnins C-M, Eleven New Triterpene Saponins from the Roots of Ilex pubescens".PLANTA MEDICA 79.1(2013):70-77.
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