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学科主题: 临床医学
题名:
MiR-29a Inhibits Cell Proliferation and Induces Cell Cycle Arrest through the Downregulation of p42.3 in Human Gastric Cancer
作者: Cui, Yun1; Su, Wen-Yu1; Xing, Jing1; Wang, Ying-Chao1; Wang, Ping2; Chen, Xiao-Yu1; Shen, Zhi-Yong3; Cao, Hui3; Lu, You-Yong4; Fang, Jing-Yuan1
刊名: PLOS ONE
发表日期: 2011-10-05
DOI: 10.1371/journal.pone.0025872
卷: 6, 期:10
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MICRORNAS ; GENOMICS
英文摘要:

As a newly identified and characterized gene, p42.3 is associated with cell proliferation and tumorigenicity. The expression of p42.3 is upregulated in human gastric cancer (GC), but its underlying mechanisms of action are not well understood. MicroRNAs (miRNAs) are known to play vital regulatory roles in many cellular processes. Here we utilized bioinformatics and experimental approaches to investigate the regulatory relationship between miRNAs and the p42.3 gene. We showed that miR-29a could repress p42.3 expression at both the mRNA and protein levels via directly binding to its 3′UTR. Furthermore, an inverse relationship was observed between miR-29a and p42.3 expression in gastric cancer cell lines and GC tissue samples, especially in cases where p42.3 was downregulated. Taken together, we have elucidated previously unrecognized roles of miR-29a and indicated that miR-29a may function, at least partially, by targeting the p42.3 gene in human GC.

语种: 英语
所属项目编号: 2010CB5293 ; 2006AA02A402 ; 30830055 ; 200802094
项目资助者: National Basic Research Program of China 973 program ; National High Technology Research and Development Program of China (863 Program) ; National Natural Science Foundation ; Ministry of Public Health, China
WOS记录号: WOS:000295966900065
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66022
Appears in Collections:北京大学临床肿瘤学院_分子肿瘤学研究室_期刊论文

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作者单位: 1.Shanghai Jiao Tong Univ, Div Gastroenterol & Hepatol, Renji Hosp, Sch Med,Shanghai Inst Digest Dis, Shanghai 200030, Peoples R China
2.Shanghai Jiao Tong Univ, GI Div, Peoples Hosp 9, Sch Med, Shanghai 200030, Peoples R China
3.Shanghai Jiao Tong Univ, GI Surg Div, Sch Med, Renji Hosp, Shanghai 200030, Peoples R China
4.Peking Univ, Mol Oncol Lab, Beijing Inst Canc Res, Sch Oncol, Beijing 100871, Peoples R China

Recommended Citation:
Cui, Yun,Su, Wen-Yu,Xing, Jing,et al. MiR-29a Inhibits Cell Proliferation and Induces Cell Cycle Arrest through the Downregulation of p42.3 in Human Gastric Cancer[J]. PLOS ONE,2011,6(10).
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