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MiR-29a Inhibits Cell Proliferation and Induces Cell Cycle Arrest through the Downregulation of p42.3 in Human Gastric Cancer
Cui, Yun1; Su, Wen-Yu1; Xing, Jing1; Wang, Ying-Chao1; Wang, Ping2; Chen, Xiao-Yu1; Shen, Zhi-Yong3; Cao, Hui3; Lu, You-Yong4; Fang, Jing-Yuan1
刊名PLOS ONE
2011-10-05
DOI10.1371/journal.pone.0025872
6期:10
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]MICRORNAS ; GENOMICS
英文摘要

As a newly identified and characterized gene, p42.3 is associated with cell proliferation and tumorigenicity. The expression of p42.3 is upregulated in human gastric cancer (GC), but its underlying mechanisms of action are not well understood. MicroRNAs (miRNAs) are known to play vital regulatory roles in many cellular processes. Here we utilized bioinformatics and experimental approaches to investigate the regulatory relationship between miRNAs and the p42.3 gene. We showed that miR-29a could repress p42.3 expression at both the mRNA and protein levels via directly binding to its 3′UTR. Furthermore, an inverse relationship was observed between miR-29a and p42.3 expression in gastric cancer cell lines and GC tissue samples, especially in cases where p42.3 was downregulated. Taken together, we have elucidated previously unrecognized roles of miR-29a and indicated that miR-29a may function, at least partially, by targeting the p42.3 gene in human GC.

语种英语
WOS记录号WOS:000295966900065
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被引频次:64[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66022
专题北京大学临床肿瘤学院_分子肿瘤学研究室
作者单位1.Shanghai Jiao Tong Univ, Div Gastroenterol & Hepatol, Renji Hosp, Sch Med,Shanghai Inst Digest Dis, Shanghai 200030, Peoples R China
2.Shanghai Jiao Tong Univ, GI Div, Peoples Hosp 9, Sch Med, Shanghai 200030, Peoples R China
3.Shanghai Jiao Tong Univ, GI Surg Div, Sch Med, Renji Hosp, Shanghai 200030, Peoples R China
4.Peking Univ, Mol Oncol Lab, Beijing Inst Canc Res, Sch Oncol, Beijing 100871, Peoples R China
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Cui, Yun,Su, Wen-Yu,Xing, Jing,et al. MiR-29a Inhibits Cell Proliferation and Induces Cell Cycle Arrest through the Downregulation of p42.3 in Human Gastric Cancer[J]. PLOS ONE,2011,6(10).
APA Cui, Yun.,Su, Wen-Yu.,Xing, Jing.,Wang, Ying-Chao.,Wang, Ping.,...&Fang, Jing-Yuan.(2011).MiR-29a Inhibits Cell Proliferation and Induces Cell Cycle Arrest through the Downregulation of p42.3 in Human Gastric Cancer.PLOS ONE,6(10).
MLA Cui, Yun,et al."MiR-29a Inhibits Cell Proliferation and Induces Cell Cycle Arrest through the Downregulation of p42.3 in Human Gastric Cancer".PLOS ONE 6.10(2011).
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