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学科主题: 药学
题名:
Macrophage mediated biomimetic delivery system for the treatment of lung metastasis of breast cancer
作者: Fu, Jijun; Wang, Dan; Mei, Dong; Zhang, Haoran; Wang, Zhaoyang; He, Bing; Dai, Wenbing; Zhang, Hua; Wang, Xueqing; Zhang, Qiang
关键词: Biomimetic delivery system (BDS) ; RAW264.7 ; Macrophages ; Doxorubicin (DOX) ; Cancer
刊名: JOURNAL OF CONTROLLED RELEASE
发表日期: 2015-04-28
DOI: 10.1016/j.jconrel.2015.01.039
卷: 204, 页:11-19
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]: Chemistry ; Pharmacology & Pharmacy
关键词[WOS]: MESENCHYMAL STEM-CELLS ; DOXORUBICIN DELIVERY ; DRUG-DELIVERY ; NANOPARTICLES ; THERAPY ; TUMORS ; LIPOSOMES ; SURVIVAL ; VEHICLES ; PRODRUG
英文摘要:

The biomimetic delivery system (BDS) based on special types of endogenous cells like macrophages and T cells, has been emerging as a novel strategy for cancer therapy, due to its tumor homing property and biocompatibility. However, its development is impeded by complicated construction, low drug loading or negative effect on the cell bioactivity. The present report constructed a BDS by loading doxorubicin (DOX) into a mouse macrophage-like cell line (RAW264.7). It was found that therapeutically meaningful amount of DOX could be loaded into the RAW264.7 cells by simply incubation, without significantly affecting the viability of the cells. Drug could release from the BDS and maintain its activity. RAW264.7 cells exhibited obvious tumor-tropic capacity towards 4T1 mouse breast cancer cells both in vitro and in vivo, and drug loading did not alter this tendency. Importantly, the DOX loaded macrophage system showed promising anti-cancer efficacy in terms of tumor suppression, life span prolongation and metastasis inhibition, with reduced toxicity. In conclusion, it is demonstrated that the BDS developed here seems to overcome some of the main issues related to a BDS. The DOX loaded macrophages might be a potential BDS for targeted cancer therapy. (C) 2015 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 81130059 ; BMU20110263
项目资助者: National Natural Science Foundation of China ; Innovation Team of Ministry of Education
WOS记录号: WOS:000352146500003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66024
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Fu, Jijun,Wang, Dan,Mei, Dong,et al. Macrophage mediated biomimetic delivery system for the treatment of lung metastasis of breast cancer[J]. JOURNAL OF CONTROLLED RELEASE,2015,204:11-19.
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