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Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects
Yue, Weihua; Kang, Guolian; Zhang, Yanbo; Qu, Mei; Tang, Fulei; Han, Yonghua; Ruan, Yan; Lu, Tianlan; Zhang, Jifeng; Zhang, Dai
关键词schizophrenia DAOA association study clinical symptom therapeutic effect
刊名NEUROSCIENCE LETTERS
2007-04-06
DOI10.1016/j.neulet.2007.01.056
416期:1页:96-100
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]BIPOLAR DISORDER ; CHINESE POPULATION ; CHROMOSOME 13Q32 ; LINKAGE ; G72/G30 ; METAANALYSIS ; GENES ; SCALE ; LOCI
英文摘要

The present study examined the correlation between variants in the D-amino acid oxidase activator (DAOA) locus and clinical symptoms and response to antipsychotics in schizophrenia. Case-control analysis and the family-based association test (FBAT) were performed to investigate whether four single nucleotide polymorphisms (SNPs) at DAOA gene are associated with schizophrenia. The association between the DAOA risk haplotype and clinical symptoms were examined by the positive and negative syndrome scale (PANSS) and the brief psychiatric rating scale (BPRS). Our findings showed that the SNP rs947267 was significantly associated with schizophrenia in both case control and familial trio samples (A > C, x(2) = 8.36, p = 0.004; Z= 2.335, p = 0.019), as well as with specific haplotypes, in particular those formed by the A allele of rs947267. In addition, the risk haplotype AAG was significantly correlated with negative, depression and cognitive impairment factors of PANSS, even with the BPRS change scores after 6-week treatment of atypical antipsychotic drugs (p < 0.05). These results support the hypothesis that variations in DAOA may play a role in schizophrenia and clinical characteristics. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

语种英语
WOS记录号WOS:000246038900019
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被引频次:29[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66028
专题北京大学精神卫生研究所
作者单位1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
3.Michigan State Univ, Dept Probabil & Stat, E Lansing, MI 48824 USA
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GB/T 7714
Yue, Weihua,Kang, Guolian,Zhang, Yanbo,et al. Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects[J]. NEUROSCIENCE LETTERS,2007,416(1):96-100.
APA Yue, Weihua.,Kang, Guolian.,Zhang, Yanbo.,Qu, Mei.,Tang, Fulei.,...&Zhang, Dai.(2007).Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects.NEUROSCIENCE LETTERS,416(1),96-100.
MLA Yue, Weihua,et al."Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects".NEUROSCIENCE LETTERS 416.1(2007):96-100.
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