北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学精神卫生研究所  > 期刊论文
学科主题: 精神卫生
题名:
Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects
作者: Yue, Weihua; Kang, Guolian; Zhang, Yanbo; Qu, Mei; Tang, Fulei; Han, Yonghua; Ruan, Yan; Lu, Tianlan; Zhang, Jifeng; Zhang, Dai
关键词: schizophrenia ; DAOA ; association study ; clinical symptom ; therapeutic effect
刊名: NEUROSCIENCE LETTERS
发表日期: 2007-04-06
DOI: 10.1016/j.neulet.2007.01.056
卷: 416, 期:1, 页:96-100
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: BIPOLAR DISORDER ; CHINESE POPULATION ; CHROMOSOME 13Q32 ; LINKAGE ; G72/G30 ; METAANALYSIS ; GENES ; SCALE ; LOCI
英文摘要:

The present study examined the correlation between variants in the D-amino acid oxidase activator (DAOA) locus and clinical symptoms and response to antipsychotics in schizophrenia. Case-control analysis and the family-based association test (FBAT) were performed to investigate whether four single nucleotide polymorphisms (SNPs) at DAOA gene are associated with schizophrenia. The association between the DAOA risk haplotype and clinical symptoms were examined by the positive and negative syndrome scale (PANSS) and the brief psychiatric rating scale (BPRS). Our findings showed that the SNP rs947267 was significantly associated with schizophrenia in both case control and familial trio samples (A > C, x(2) = 8.36, p = 0.004; Z= 2.335, p = 0.019), as well as with specific haplotypes, in particular those formed by the A allele of rs947267. In addition, the risk haplotype AAG was significantly correlated with negative, depression and cognitive impairment factors of PANSS, even with the BPRS change scores after 6-week treatment of atypical antipsychotic drugs (p < 0.05). These results support the hypothesis that variations in DAOA may play a role in schizophrenia and clinical characteristics. (c) 2007 Elsevier Ireland Ltd. All rights reserved.

语种: 英语
WOS记录号: WOS:000246038900019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66028
Appears in Collections:北京大学精神卫生研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.Peking Univ, Inst Mental Hlth, Beijing 100083, Peoples R China
2.Chinese Acad Sci, Acad Math & Syst Sci, Beijing, Peoples R China
3.Michigan State Univ, Dept Probabil & Stat, E Lansing, MI 48824 USA

Recommended Citation:
Yue, Weihua,Kang, Guolian,Zhang, Yanbo,et al. Association of DAOA polymorphisms with schizophrenia and clinical symptoms or therapeutic effects[J]. NEUROSCIENCE LETTERS,2007,416(1):96-100.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Yue, Weihua]'s Articles
[Kang, Guolian]'s Articles
[Zhang, Yanbo]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Yue, Weihua]‘s Articles
[Kang, Guolian]‘s Articles
[Zhang, Yanbo]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace