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Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?
Huang, Shuo; Qiao, Jie; Li, Rong; Wang, Lina; Li, Meizhi
关键词Apolipoprotein C-I insulin resistance metabolism polycystic ovary syndrome
刊名FERTILITY AND STERILITY
2010-06-01
DOI10.1016/j.fertnstert.2009.03.005
94期:1页:205-210
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]CORONARY-ARTERY-DISEASE ; LOW-DENSITY LIPOPROTEINS ; TRANSGENIC MICE ; NORMOLIPIDEMIC MEN ; INSULIN-RESISTANCE ; APOC-I ; OVEREXPRESSION ; HYPERLIPIDEMIA ; PREVALENCE ; HEALTH
英文摘要

Objective: To evaluate the role of apolipoprotein C-I (apoC-I) levels and assess relationships between apoC-I and clinical features in women with polycystic ovary syndrome (PCOS).

Design: Prospective study.

Setting: Reproductive Center of Peking University Third Hospital.

Patient(s): Thirty patients with PCOS with insulin resistance, 30 patients with PCOS without insulin resistance, and 30 control individuals.

Intervention(s): Fasting serum samples.

Main Outcome Measure(s): Measures of serum apoC-I, androgens, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoA1, apoB, heat-shock C-reactive protein, glucose, and homeostasis model assessment of insulin resistance (HOMA-IR).

Result(s): We found differentially expressed proteins by use of the surface-enhanced laser adsorption/ionization (SELDI) protein chip in the serum of women with PCOS and controls. Of these, apoC-I, was highly up-regulated. ApoC-I is associated with glycometabolism and lipid metabolism, but its role in PCOS has been unknown. The serum levels of apoC-I in the patients with PCOS were statistically significantly elevated compared with those of controls, especially in women with insulin resistance. The lean PCOS women had higher apoC-I levels than controls. In patients with PCOS and without any abnormal serum lipid index, apoC-I levels were still higher than in controls. Analysis showed that apoC-I correlated with body mass index, triglycerides, high-density lipoprotein cholesterol, apoA1, and HOMA-IR.

Conclusion(s): ApoC-I may have an important role in glucose and lipid metabolism, and may be useful for early demonstration of metabolic abnormality in women with PCOS. (Fertil Steril (R) 2010; 94: 205-10. (C) 2010 by American Society for Reproductive Medicine.)

语种英语
WOS记录号WOS:000278858200034
项目编号30825038 ; 30570872
资助机构Chinese National Science Fund for distinguished young scholars ; Chinese National Natural Science Foundation
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66029
专题北京大学第三临床医学院
北京大学第三临床医学院_生殖医学中心
作者单位Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Huang, Shuo,Qiao, Jie,Li, Rong,et al. Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?[J]. FERTILITY AND STERILITY,2010,94(1):205-210.
APA Huang, Shuo,Qiao, Jie,Li, Rong,Wang, Lina,&Li, Meizhi.(2010).Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?.FERTILITY AND STERILITY,94(1),205-210.
MLA Huang, Shuo,et al."Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?".FERTILITY AND STERILITY 94.1(2010):205-210.
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