北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第三临床医学院  > 期刊论文
学科主题: 临床医学
题名:
Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?
作者: Huang, Shuo; Qiao, Jie; Li, Rong; Wang, Lina; Li, Meizhi
关键词: Apolipoprotein C-I ; insulin resistance ; metabolism ; polycystic ovary syndrome
刊名: FERTILITY AND STERILITY
发表日期: 2010-06-01
DOI: 10.1016/j.fertnstert.2009.03.005
卷: 94, 期:1, 页:205-210
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Obstetrics & Gynecology ; Reproductive Biology
研究领域[WOS]: Obstetrics & Gynecology ; Reproductive Biology
关键词[WOS]: CORONARY-ARTERY-DISEASE ; LOW-DENSITY LIPOPROTEINS ; TRANSGENIC MICE ; NORMOLIPIDEMIC MEN ; INSULIN-RESISTANCE ; APOC-I ; OVEREXPRESSION ; HYPERLIPIDEMIA ; PREVALENCE ; HEALTH
英文摘要:

Objective: To evaluate the role of apolipoprotein C-I (apoC-I) levels and assess relationships between apoC-I and clinical features in women with polycystic ovary syndrome (PCOS).

Design: Prospective study.

Setting: Reproductive Center of Peking University Third Hospital.

Patient(s): Thirty patients with PCOS with insulin resistance, 30 patients with PCOS without insulin resistance, and 30 control individuals.

Intervention(s): Fasting serum samples.

Main Outcome Measure(s): Measures of serum apoC-I, androgens, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoA1, apoB, heat-shock C-reactive protein, glucose, and homeostasis model assessment of insulin resistance (HOMA-IR).

Result(s): We found differentially expressed proteins by use of the surface-enhanced laser adsorption/ionization (SELDI) protein chip in the serum of women with PCOS and controls. Of these, apoC-I, was highly up-regulated. ApoC-I is associated with glycometabolism and lipid metabolism, but its role in PCOS has been unknown. The serum levels of apoC-I in the patients with PCOS were statistically significantly elevated compared with those of controls, especially in women with insulin resistance. The lean PCOS women had higher apoC-I levels than controls. In patients with PCOS and without any abnormal serum lipid index, apoC-I levels were still higher than in controls. Analysis showed that apoC-I correlated with body mass index, triglycerides, high-density lipoprotein cholesterol, apoA1, and HOMA-IR.

Conclusion(s): ApoC-I may have an important role in glucose and lipid metabolism, and may be useful for early demonstration of metabolic abnormality in women with PCOS. (Fertil Steril (R) 2010; 94: 205-10. (C) 2010 by American Society for Reproductive Medicine.)

语种: 英语
所属项目编号: 30825038 ; 30570872
项目资助者: Chinese National Science Fund for distinguished young scholars ; Chinese National Natural Science Foundation
WOS记录号: WOS:000278858200034
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66029
Appears in Collections:北京大学第三临床医学院_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing, Peoples R China

Recommended Citation:
Huang, Shuo,Qiao, Jie,Li, Rong,et al. Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?[J]. FERTILITY AND STERILITY,2010,94(1):205-210.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Huang, Shuo]'s Articles
[Qiao, Jie]'s Articles
[Li, Rong]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Huang, Shuo]‘s Articles
[Qiao, Jie]‘s Articles
[Li, Rong]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace