|Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?|
|Huang, Shuo; Qiao, Jie; Li, Rong; Wang, Lina; Li, Meizhi|
|关键词||Apolipoprotein C-I insulin resistance metabolism polycystic ovary syndrome|
|刊名||FERTILITY AND STERILITY|
|WOS标题词||Science & Technology|
|类目[WOS]||Obstetrics & Gynecology ; Reproductive Biology|
|研究领域[WOS]||Obstetrics & Gynecology ; Reproductive Biology|
|关键词[WOS]||CORONARY-ARTERY-DISEASE ; LOW-DENSITY LIPOPROTEINS ; TRANSGENIC MICE ; NORMOLIPIDEMIC MEN ; INSULIN-RESISTANCE ; APOC-I ; OVEREXPRESSION ; HYPERLIPIDEMIA ; PREVALENCE ; HEALTH|
Objective: To evaluate the role of apolipoprotein C-I (apoC-I) levels and assess relationships between apoC-I and clinical features in women with polycystic ovary syndrome (PCOS).
Design: Prospective study.
Setting: Reproductive Center of Peking University Third Hospital.
Patient(s): Thirty patients with PCOS with insulin resistance, 30 patients with PCOS without insulin resistance, and 30 control individuals.
Intervention(s): Fasting serum samples.
Main Outcome Measure(s): Measures of serum apoC-I, androgens, total cholesterol, triglycerides, high-density lipoprotein cholesterol, low-density lipoprotein cholesterol, apoA1, apoB, heat-shock C-reactive protein, glucose, and homeostasis model assessment of insulin resistance (HOMA-IR).
Result(s): We found differentially expressed proteins by use of the surface-enhanced laser adsorption/ionization (SELDI) protein chip in the serum of women with PCOS and controls. Of these, apoC-I, was highly up-regulated. ApoC-I is associated with glycometabolism and lipid metabolism, but its role in PCOS has been unknown. The serum levels of apoC-I in the patients with PCOS were statistically significantly elevated compared with those of controls, especially in women with insulin resistance. The lean PCOS women had higher apoC-I levels than controls. In patients with PCOS and without any abnormal serum lipid index, apoC-I levels were still higher than in controls. Analysis showed that apoC-I correlated with body mass index, triglycerides, high-density lipoprotein cholesterol, apoA1, and HOMA-IR.
Conclusion(s): ApoC-I may have an important role in glucose and lipid metabolism, and may be useful for early demonstration of metabolic abnormality in women with PCOS. (Fertil Steril (R) 2010; 94: 205-10. (C) 2010 by American Society for Reproductive Medicine.)
|项目编号||30825038 ; 30570872|
|资助机构||Chinese National Science Fund for distinguished young scholars ; Chinese National Natural Science Foundation|
|作者单位||Peking Univ, Hosp 3, Dept Obstet & Gynecol, Beijing, Peoples R China|
|Huang, Shuo,Qiao, Jie,Li, Rong,et al. Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?[J]. FERTILITY AND STERILITY,2010,94(1):205-210.|
|APA||Huang, Shuo,Qiao, Jie,Li, Rong,Wang, Lina,&Li, Meizhi.(2010).Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?.FERTILITY AND STERILITY,94(1),205-210.|
|MLA||Huang, Shuo,et al."Can serum apolipoprotein C-I demonstrate metabolic abnormality early in women with polycystic ovary syndrome?".FERTILITY AND STERILITY 94.1(2010):205-210.|