北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第一临床医学院  > 皮肤性病科  > 期刊论文
学科主题: 临床医学
题名:
Rhinocladiella aquaspersa, proven agent of verrucous skin infection and a novel type of chromoblastomycosis
作者: Badali, H.1,2,3; Bonifaz, A.4,7; Barron-Tapia, T.5; Vazquez-Gonzalez, D.4,7; Estrada-Aguilar, L.5; Cavalcante Oliveira, N. M.6; Sobral Filho, J. F.7; Guarro, J.8; Meis, J. F. G. M.9; De Hoog, G. S.1,2,10
关键词: chromoblastomycosis ; Rhinocladiella aquaspersa ; Rhinocladiella phaeophora ; ITS rDNA ; black yeasts
刊名: MEDICAL MYCOLOGY
发表日期: 2010-08-01
DOI: 10.3109/13693780903471073
卷: 48, 期:5, 页:696-703
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Mycology ; Veterinary Sciences
研究领域[WOS]: Mycology ; Veterinary Sciences
关键词[WOS]: IN-VITRO ACTIVITIES ; ACROTHECA-AQUASPERSA ; EXOPHIALA-JEANSELMEI ; FONSECAEA-PEDROSOI ; FUNGI ; RAMICHLORIDIUM ; CHROMOMYCOSIS ; PHEOHYPHOMYCOSIS ; MACKENZIEI ; ANTIGENS
英文摘要:

We report a case of chromoblastomycosis which resembled sporotrichosis due to the presence of warty nodules and lymphatic distribution on the forearm in a 56-year-old male. Mycological and histopathological investigation of exudates and biopsy tissue samples revealed a granulomatous lesion with muriform cells, the hallmark of chromoblastomycosis. The infection showed only localized expansion with verrucous plaques suggesting a new clinical type of the disease. The causative agent was identified as Rhinocladiella aquaspersa. This case prompted a study of the clinical spectrum of R. aquaspersa, through which we identified a second case caused by this fungus in a 62-year-old Brazilian female. The case was unusual in that R. aquaspersa exhibited hyphae rather than muriform cells in tissue. Given the difficulties treating chromoblastomycosis and other infections caused by melanized fungi, we evaluated the in vitro activities of extended-spectrum triazoles, amphotericin B, and echinocandins against these clinical isolates of R. aquaspersa. Itraconazole (MIC; 0.063 mg/l) and posaconazole (MIC; 0.125 mg/l) had the highest in vitro activities, while voriconazole and isavuconazole had somewhat lower activities (MICs; 2 mg/l) against the isolates. Amphotericin B and anidulafungin each had an MIC of 1 mg/l, whereas the MIC of caspofungin was 8 mg/l.

语种: 英语
所属项目编号: 13081
项目资助者: Iranian Ministry of Health ; Medical Education of Islamic Republic of Iran ; School of Medicine, Mazandaran University of Medical Sciences, Sari, Iran
WOS记录号: WOS:000280700800003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66032
Appears in Collections:北京大学第一临床医学院_皮肤性病科_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: 1.CBS KNAW Fungal Biodivers Ctr, NL-3508 AD Utrecht, Netherlands
2.Univ Amsterdam, Inst Biodivers & Ecosyst Dynam, Amsterdam, Netherlands
3.Mazandaran Univ Med Sci, Sch Med, Mol & Cell Biol Res Ctr, Dept Med Mycol & Parasitol, Sari, Iran
4.Gen Hosp Mexico, Dermatol Serv, Dept Mycol, Mexico City, DF, Mexico
5.Reg Hosp Lic Adolfo Lopez Mateos, Dermatol Serv, Mexico City, DF, Mexico
6.Univ Fed Paraiba, Dept Ciencias Farmaceut, Lab Micol, BR-58059900 Joao Pessoa, Paraiba, Brazil
7.Univ Fed Paraiba, Hosp Univ Lauro Wanderley, Serv Dermatol, BR-58059900 Joao Pessoa, Paraiba, Brazil
8.Univ Rovira & Virgili, IISPV, Sch Med, Mycol Unit, E-43201 Reus, Spain
9.Canisius Wilhelmina Hosp, Dept Med Microbiol & Infect Dis, Nijmegen, Netherlands
10.Peking Univ, Hlth Sci Ctr, Res Ctr Med Mycol, Beijing 100871, Peoples R China

Recommended Citation:
Badali, H.,Bonifaz, A.,Barron-Tapia, T.,et al. Rhinocladiella aquaspersa, proven agent of verrucous skin infection and a novel type of chromoblastomycosis[J]. MEDICAL MYCOLOGY,2010,48(5):696-703.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Badali, H.]'s Articles
[Bonifaz, A.]'s Articles
[Barron-Tapia, T.]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Badali, H.]‘s Articles
[Bonifaz, A.]‘s Articles
[Barron-Tapia, T.]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit
所有评论 (0)
暂无评论
 
评注功能仅针对注册用户开放,请您登录
您对该条目有什么异议,请填写以下表单,管理员会尽快联系您。
内 容:
Email:  *
单位:
验证码:   刷新
您在IR的使用过程中有什么好的想法或者建议可以反馈给我们。
标 题:
 *
内 容:
Email:  *
验证码:   刷新

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace