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学科主题: 临床医学
题名:
Elevation of serum von Willebrand factor and anti-endothelial cell antibodies in patients with immunoglobulin A nephropathy are associated with intrarenal arterial lesions
作者: Zhang, Jun-Jun; Jiang, Lei; Liu, Gang; Wang, Su-Xia; Zou, Wan-Zhong; Zhang, Hong; Zhao, Ming-Hui
关键词: anti-endothelial cell antibodies ; immunoglobulin A nephropathy ; intrarenal arterial lesions ; von Willebrand factor
刊名: NEPHROLOGY
发表日期: 2008-12-01
DOI: 10.1111/j.1440-1797.2008.00983.x
卷: 13, 期:8, 页:712-720
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Urology & Nephrology
研究领域[WOS]: Urology & Nephrology
关键词[WOS]: IDIOPATHIC IGA NEPHROPATHY ; ENDOTHELIAL-CELLS ; VASCULITIS ; DISEASE ; SCLEROSIS ; ANTIGEN ; CHINA
英文摘要:

Recent studies suggest that intrarenal arterial lesions are frequently observed in patients with immunoglobulin A nephropathy (IgAN). However, the mechanisms of the injury have not been elucidated. The level of serum von Willebrand factor (vWF) and the prevalence of anti-endothelial cell antibodies (AECA) were investigated in patients with IgAN with different intrarenal arterial lesions.

Sera from 28 patients with mild intrarenal arterial lesions (group 1) and 36 patients with severe intrarenal arterial lesions (group 2) were collected. Sera from 20 patients with idiopathic membranous nephropathy (group 3) and 50 healthy volunteers were also obtained as disease and normal controls, respectively. Serum vWF and AECA of both IgG and IgA isotype were detected.

In comparison with normal controls, serum vWF was significantly higher in group 2 and group 3. Serum vWF was also significantly higher in group 2 than in group 1. Both IgG-AECA and IgA-AECA could be detected in three groups of patients. The prevalence of anti-87 kD IgG-AECA was greatest in patients in group 2. IgAN patients, especially those in group 2 with IgG-AECA or anti-87 kD IgG-AECA, had significantly higher serum creatinine and lower creatinine clearance than those without. No significant difference could be found for IgA-AECA. The level of serum vWF was higher in IgAN patients with IgG-AECA than that in patients without.

Intrarenal arterial lesions are associated with endothelial cell damage in IgAN, and vWF is a useful serological biomarker of severe intrarenal arterial lesions. AECA, especially IgG-AECA, may play an important role in the pathogenesis of intrarenal arterial damage in IgAN.

语种: 英语
所属项目编号: 30570852 ; 2004230003
项目资助者: National Natural Science Foundation of China ; Ministry of Health, China
WOS记录号: WOS:000261962400010
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66036
Appears in Collections:北京大学第一临床医学院_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Med,Minist Hlth China, Div Renal,Inst Nephrol,Key Lab Renal Dis, Beijing 100034, Peoples R China

Recommended Citation:
Zhang, Jun-Jun,Jiang, Lei,Liu, Gang,et al. Elevation of serum von Willebrand factor and anti-endothelial cell antibodies in patients with immunoglobulin A nephropathy are associated with intrarenal arterial lesions[J]. NEPHROLOGY,2008,13(8):712-720.
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