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Elevation of serum von Willebrand factor and anti-endothelial cell antibodies in patients with immunoglobulin A nephropathy are associated with intrarenal arterial lesions
Zhang, Jun-Jun; Jiang, Lei; Liu, Gang; Wang, Su-Xia; Zou, Wan-Zhong; Zhang, Hong; Zhao, Ming-Hui
关键词anti-endothelial cell antibodies immunoglobulin A nephropathy intrarenal arterial lesions von Willebrand factor
刊名NEPHROLOGY
2008-12-01
DOI10.1111/j.1440-1797.2008.00983.x
13期:8页:712-720
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Urology & Nephrology
研究领域[WOS]Urology & Nephrology
关键词[WOS]IDIOPATHIC IGA NEPHROPATHY ; ENDOTHELIAL-CELLS ; VASCULITIS ; DISEASE ; SCLEROSIS ; ANTIGEN ; CHINA
英文摘要

Recent studies suggest that intrarenal arterial lesions are frequently observed in patients with immunoglobulin A nephropathy (IgAN). However, the mechanisms of the injury have not been elucidated. The level of serum von Willebrand factor (vWF) and the prevalence of anti-endothelial cell antibodies (AECA) were investigated in patients with IgAN with different intrarenal arterial lesions.

Sera from 28 patients with mild intrarenal arterial lesions (group 1) and 36 patients with severe intrarenal arterial lesions (group 2) were collected. Sera from 20 patients with idiopathic membranous nephropathy (group 3) and 50 healthy volunteers were also obtained as disease and normal controls, respectively. Serum vWF and AECA of both IgG and IgA isotype were detected.

In comparison with normal controls, serum vWF was significantly higher in group 2 and group 3. Serum vWF was also significantly higher in group 2 than in group 1. Both IgG-AECA and IgA-AECA could be detected in three groups of patients. The prevalence of anti-87 kD IgG-AECA was greatest in patients in group 2. IgAN patients, especially those in group 2 with IgG-AECA or anti-87 kD IgG-AECA, had significantly higher serum creatinine and lower creatinine clearance than those without. No significant difference could be found for IgA-AECA. The level of serum vWF was higher in IgAN patients with IgG-AECA than that in patients without.

Intrarenal arterial lesions are associated with endothelial cell damage in IgAN, and vWF is a useful serological biomarker of severe intrarenal arterial lesions. AECA, especially IgG-AECA, may play an important role in the pathogenesis of intrarenal arterial damage in IgAN.

语种英语
WOS记录号WOS:000261962400010
项目编号30570852 ; 2004230003
资助机构National Natural Science Foundation of China ; Ministry of Health, China
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66036
专题北京大学第一临床医学院
北京大学基础医学院
北京大学第一临床医学院_病理科
北京大学第一临床医学院_电镜室
北京大学第一临床医学院_肾脏内科
作者单位Peking Univ, Hosp 1, Dept Med,Minist Hlth China, Div Renal,Inst Nephrol,Key Lab Renal Dis, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Jun-Jun,Jiang, Lei,Liu, Gang,et al. Elevation of serum von Willebrand factor and anti-endothelial cell antibodies in patients with immunoglobulin A nephropathy are associated with intrarenal arterial lesions[J]. NEPHROLOGY,2008,13(8):712-720.
APA Zhang, Jun-Jun.,Jiang, Lei.,Liu, Gang.,Wang, Su-Xia.,Zou, Wan-Zhong.,...&Zhao, Ming-Hui.(2008).Elevation of serum von Willebrand factor and anti-endothelial cell antibodies in patients with immunoglobulin A nephropathy are associated with intrarenal arterial lesions.NEPHROLOGY,13(8),712-720.
MLA Zhang, Jun-Jun,et al."Elevation of serum von Willebrand factor and anti-endothelial cell antibodies in patients with immunoglobulin A nephropathy are associated with intrarenal arterial lesions".NEPHROLOGY 13.8(2008):712-720.
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