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IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科  > 期刊论文
学科主题: 临床医学
题名:
Icariin on relaxation effect of corpus cavernosum smooth muscle
作者: Xin, ZC; Kim, EY; Tian, ZJ; Lin, GT; Guo, YL
关键词: icariin ; corpus cavernosm ; cGMP ; erection
刊名: CHINESE SCIENCE BULLETIN
发表日期: 2001-07-01
卷: 46, 期:14, 页:1186-1191
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: IN-VITRO ; SILDENAFIL ; PAPAVERINE ; IMPOTENCE
英文摘要:

NO-cGMP pathway in penile corpus cavernosal smooth muscle plays an important role in penile erection. The level of cGMP is regulated by a balance between the rate of synthesis by guanylate cyclase and the rate of hydrolytic breakdown to guanosine 5′ monophosphate (GMP) by phosphodiesterase 5(PDE5). Icariin is isolated from natural drug Epimedii herba, it is shown to have the relaxation effect on corpus cavernosal smooth muscle of rabbit (IC50: 4x10(-4) mol/L), and the mechanism of the relaxation effect of Icariin on corpus cavernosum, believed to have the inhibiting effect on PDE5 and activation of NO-cGMP pathway to enhancing penile erection.

语种: 英语
WOS记录号: WOS:000170304100012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66039
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Beijing Univ, First Hosp, Dept Urol, Beijing 100034, Peoples R China
2.Pohang Univ Sci & Technol, Dept Life Sci, Pohang, South Korea

Recommended Citation:
Xin, ZC,Kim, EY,Tian, ZJ,et al. Icariin on relaxation effect of corpus cavernosum smooth muscle[J]. CHINESE SCIENCE BULLETIN,2001,46(14):1186-1191.
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