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Twenty-Four-Hour Urinary Sodium Excretion and Postural Orthostatic Tachycardia Syndrome
Zhang, Qingyou1; Liao, Ying1; Tang, Chaoshu2; Du, Junbao1; Jin, Hongfang1
刊名JOURNAL OF PEDIATRICS
2012-08-01
DOI10.1016/j.jpeds.2012.01.054
161期:2页:281-284
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Pediatrics
研究领域[WOS]Pediatrics
关键词[WOS]INTOLERANCE ; ADOLESCENTS ; VOLUME ; SYNCOPE
英文摘要

Objective To investigate whether 24-hour urinary sodium excretion could be an indicator of the effectiveness of salt supplementation in children with postural orthostatic tachycardia syndrome (POTS).

Study design The patient group comprised 30 children with POTS, and the control group comprised 10 healthy children. Serum sodium and 24-hour urinary sodium excretion were measured in all children, and the relationship between 24-hour urinary sodium and symptom severity was analyzed in the 30 patients. At 1 month after initiation of salt supplementation, the receiver operating characteristic curve was used to explore the probability of correctly discriminating responders to salt supplementation from nonresponders using 24-hour urinary sodium excretion as an indicator.

Results Patients with POTS had lower 24-hour urinary sodium excretion than controls (P = .022). Symptom severity was negatively correlated with 24-hour urinary sodium excretion (OR, -0.754; P = .000). The receiver operating characteristic curve demonstrated a sensitivity of 76.9% and specificity of 93% for correct prediction of responders and nonresponders to salt supplementation when a 24-hour urinary sodium excretion of 124 mmol/24 hours was used as the cutoff value.

Conclusion Our results indicate that 24-hour sodium excretion of < 124 mmol/24 hours is an indicator of the effectiveness of salt supplementation in children and adolescents with POTS. (J Pediatr 2012;161:281-4).

语种英语
WOS记录号WOS:000306693800023
项目编号2012BA103B03 ; D10100050010059
资助机构National Twelfth Five-Year Plan for Science and Technology ; Beijing Science and Technology Program
引用统计
被引频次:21[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66040
专题北京大学第一临床医学院_儿科
北京大学基础医学院
作者单位1.Peking Univ, Hosp 1, Dept Pediat, Beijing 100034, Peoples R China
2.Peking Univ, Dept Physiol & Pathophysiol, Hlth Sci Ctr, Beijing 100034, Peoples R China
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GB/T 7714
Zhang, Qingyou,Liao, Ying,Tang, Chaoshu,et al. Twenty-Four-Hour Urinary Sodium Excretion and Postural Orthostatic Tachycardia Syndrome[J]. JOURNAL OF PEDIATRICS,2012,161(2):281-284.
APA Zhang, Qingyou,Liao, Ying,Tang, Chaoshu,Du, Junbao,&Jin, Hongfang.(2012).Twenty-Four-Hour Urinary Sodium Excretion and Postural Orthostatic Tachycardia Syndrome.JOURNAL OF PEDIATRICS,161(2),281-284.
MLA Zhang, Qingyou,et al."Twenty-Four-Hour Urinary Sodium Excretion and Postural Orthostatic Tachycardia Syndrome".JOURNAL OF PEDIATRICS 161.2(2012):281-284.
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