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学科主题: 临床医学
题名:
Impact of Orchiectomy on the Adrenal Metabolism of Pregnenolone, 17 alpha-Hydroxypregnenolone and Dehydroepiandrosterone in Rats
作者: Hua Hai-Yin1; Chen Jun1; Fan Xue-Mei2; Hu Ming-Qiu3; Liang Qiong-Lin1; Na Yan-Qun3; Wang Yi-Ming1; Luo Guo-An1
关键词: Orchiectomy ; Adrenal ; Gas chromatography with mass spectrometry ; 17 alpha-Hydroxypregnenolone ; Dehydroepiandrosterone
刊名: CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
发表日期: 2011-02-10
卷: 32, 期:2, 页:258-261
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Multidisciplinary
研究领域[WOS]: Chemistry
关键词[WOS]: CHROMATOGRAPHY-MASS-SPECTROMETRY ; ANABOLIC-STEROIDS ; GC-MS ; URINE ; VALIDATION ; TESTOSTERONE ; PROSTATE
英文摘要:

Androgen deprivation therapy, the main method for clinical prostate cancer, was proved to be able to promote the expression of CYP17 alpha 1 gene in adrenal. As CYP17 alpha 1 was the crucial enzyme for the production of 17 alpha-hydroxypregnenolone and dehydroepiandrosterone, a CC-MS method was established to illustrate the change of pregnenolone, 17 alpha-hydroxypregnenolone and dehydroepiandrosterone after orchiectomy in emasculated rat adrenal. Twenty-eight days after orchiectomy, there was a significant increase of 17 alpha-hydroxypregnenolone and dehydroepiandrosterone accompanied with the increase of CYP17 alpha 1 gene expression 14 d after orchiectomy in adrenal.

语种: 中文
WOS记录号: WOS:000287826200012
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66045
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Dept Chem, Beijing 100084, Peoples R China
2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
3.Peking Univ, Hosp 1, Inst Urol, Beijing 100034, Peoples R China

Recommended Citation:
Hua Hai-Yin,Chen Jun,Fan Xue-Mei,et al. Impact of Orchiectomy on the Adrenal Metabolism of Pregnenolone, 17 alpha-Hydroxypregnenolone and Dehydroepiandrosterone in Rats[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2011,32(2):258-261.
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