IR@PKUHSC  > 北京大学第一临床医学院  > 泌尿外科
学科主题临床医学
Impact of Orchiectomy on the Adrenal Metabolism of Pregnenolone, 17 alpha-Hydroxypregnenolone and Dehydroepiandrosterone in Rats
Hua Hai-Yin1; Chen Jun1; Fan Xue-Mei2; Hu Ming-Qiu3; Liang Qiong-Lin1; Na Yan-Qun3; Wang Yi-Ming1; Luo Guo-An1
关键词Orchiectomy Adrenal Gas chromatography with mass spectrometry 17 alpha-Hydroxypregnenolone Dehydroepiandrosterone
刊名CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE
2011-02-10
32期:2页:258-261
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary
研究领域[WOS]Chemistry
关键词[WOS]CHROMATOGRAPHY-MASS-SPECTROMETRY ; ANABOLIC-STEROIDS ; GC-MS ; URINE ; VALIDATION ; TESTOSTERONE ; PROSTATE
英文摘要

Androgen deprivation therapy, the main method for clinical prostate cancer, was proved to be able to promote the expression of CYP17 alpha 1 gene in adrenal. As CYP17 alpha 1 was the crucial enzyme for the production of 17 alpha-hydroxypregnenolone and dehydroepiandrosterone, a CC-MS method was established to illustrate the change of pregnenolone, 17 alpha-hydroxypregnenolone and dehydroepiandrosterone after orchiectomy in emasculated rat adrenal. Twenty-eight days after orchiectomy, there was a significant increase of 17 alpha-hydroxypregnenolone and dehydroepiandrosterone accompanied with the increase of CYP17 alpha 1 gene expression 14 d after orchiectomy in adrenal.

语种中文
WOS记录号WOS:000287826200012
引用统计
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66045
专题北京大学第一临床医学院_泌尿外科
作者单位1.Tsinghua Univ, Key Lab Bioorgan Phosphorus Chem & Chem Biol, Minist Educ, Dept Chem, Beijing 100084, Peoples R China
2.E China Univ Sci & Technol, Sch Pharm, Shanghai 200237, Peoples R China
3.Peking Univ, Hosp 1, Inst Urol, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Hua Hai-Yin,Chen Jun,Fan Xue-Mei,et al. Impact of Orchiectomy on the Adrenal Metabolism of Pregnenolone, 17 alpha-Hydroxypregnenolone and Dehydroepiandrosterone in Rats[J]. CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,2011,32(2):258-261.
APA Hua Hai-Yin.,Chen Jun.,Fan Xue-Mei.,Hu Ming-Qiu.,Liang Qiong-Lin.,...&Luo Guo-An.(2011).Impact of Orchiectomy on the Adrenal Metabolism of Pregnenolone, 17 alpha-Hydroxypregnenolone and Dehydroepiandrosterone in Rats.CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE,32(2),258-261.
MLA Hua Hai-Yin,et al."Impact of Orchiectomy on the Adrenal Metabolism of Pregnenolone, 17 alpha-Hydroxypregnenolone and Dehydroepiandrosterone in Rats".CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE 32.2(2011):258-261.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Hua Hai-Yin]的文章
[Chen Jun]的文章
[Fan Xue-Mei]的文章
百度学术
百度学术中相似的文章
[Hua Hai-Yin]的文章
[Chen Jun]的文章
[Fan Xue-Mei]的文章
必应学术
必应学术中相似的文章
[Hua Hai-Yin]的文章
[Chen Jun]的文章
[Fan Xue-Mei]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。