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Early predictive efficacy of core antigen on antiviral outcomes in genotype 1 hepatitis C virus infected patients
Feng, Bo; Yang, Rui-Feng; Zhang, Hai-Ying; Luo, Bi-Fen; Kong, Fan-Yun; Rao, Hui-Ying; Jin, Qian; Cong, Xu; Wei, Lai
关键词Hepatitis C Genotype 1 HCV core antigen HCV treatment
刊名BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
2015-07-01
DOI10.1016/j.bjid.2015.04.007
19期:4页:390-398
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases
研究领域[WOS]Infectious Diseases
关键词[WOS]HCV RNA ; LIVER ; IMMUNOASSAY ; ASSAY
英文摘要

Response-guided therapy is of limited use in developing countries because hepatitis C virus RNA detection by sensitive molecular methods is time- and labor-consuming and expensive. We evaluated early predictive efficacy of serum hepatitis C virus core antigen kinetics on sustained virologic response in patients with genotype 1 hepatitis C virus during pegylated interferon plus ribavirin treatment. For 478 patients recruited, hepatitis C virus RNAs were detected at baseline, and at weeks 4, 12, 24, 48, and 72 using Cobas TaqMan. Architect hepatitis C virus core antigen was performed at baseline, and weeks 4 and 12. Predictive values of hepatitis C virus core antigen on sustained virologic response were compared to hepatitis C virus RNA. In the first 12 weeks after treatment initiation the dynamic patterns of serum hepatitis C virus core antigen and hepatitis C virus RNA levels were similar in sustained virologic response, relapse, and null response patients groups. Although areas under the receiver operating characteristics curves of hepatitis C virus core antigen were lower than those of hepatitis C virus RNA at the same time points, modeling analysis showed that undetectable hepatitis C virus core antigen (rapid virological response based on hepatitis C virus core antigen) had similar positive predictive value on sustained virologic response to hepatitis C virus RNA at week 4 (90.4% vs 93.3%), and hepatitis C virus core antigen decrease greater than 1 logio IU/mL (early virological response based on hepatitis C virus core antigen) had similar negative predictive value to hepatitis C virus RNA at week 12 (94.1% vs 95.2%). Analysis on the validation group demonstrated a positive predictivevalue of 97.5% in rapid virological response based on hepatitis C virus core antigen and a negative predictive value of 100% in early virological response based on hepatitis C virus core antigen. In conclusion, hepatitis C virus core antigen is comparable to hepatitis C virus RNA in predicting sustained virologic response of chronic genotype 1 hepatitis C virus infected patients, and can be used to guide anti-hepatitis C virus treatment, especially in resource-limited areas. (C) 2015 Elsevier Editora Ltda. All rights reserved.

语种英语
WOS记录号WOS:000358803200008
项目编号2012ZX10002-003 ; 2012ZX09303-019 ; 7122191
资助机构National S&amp ; T Major Project for Infectious Diseases Control ; National Major S&amp ; T Special Project for "Significant New Drugs Development" ; Beijing Natural Science Foundation
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66048
专题北京大学第二临床医学院_肝病科
北京大学第二临床医学院_北京大学肝病研究所
作者单位Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100871, Peoples R China
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GB/T 7714
Feng, Bo,Yang, Rui-Feng,Zhang, Hai-Ying,et al. Early predictive efficacy of core antigen on antiviral outcomes in genotype 1 hepatitis C virus infected patients[J]. BRAZILIAN JOURNAL OF INFECTIOUS DISEASES,2015,19(4):390-398.
APA Feng, Bo.,Yang, Rui-Feng.,Zhang, Hai-Ying.,Luo, Bi-Fen.,Kong, Fan-Yun.,...&Wei, Lai.(2015).Early predictive efficacy of core antigen on antiviral outcomes in genotype 1 hepatitis C virus infected patients.BRAZILIAN JOURNAL OF INFECTIOUS DISEASES,19(4),390-398.
MLA Feng, Bo,et al."Early predictive efficacy of core antigen on antiviral outcomes in genotype 1 hepatitis C virus infected patients".BRAZILIAN JOURNAL OF INFECTIOUS DISEASES 19.4(2015):390-398.
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