北京大学医学部机构知识库
Advanced  
IR@PKUHSC  > 北京大学第二临床医学院  > 北京大学肝病研究所  > 期刊论文
学科主题: 临床医学
题名:
Early predictive efficacy of core antigen on antiviral outcomes in genotype 1 hepatitis C virus infected patients
作者: Feng, Bo; Yang, Rui-Feng; Zhang, Hai-Ying; Luo, Bi-Fen; Kong, Fan-Yun; Rao, Hui-Ying; Jin, Qian; Cong, Xu; Wei, Lai
关键词: Hepatitis C ; Genotype 1 ; HCV core antigen ; HCV treatment
刊名: BRAZILIAN JOURNAL OF INFECTIOUS DISEASES
发表日期: 2015-07-01
DOI: 10.1016/j.bjid.2015.04.007
卷: 19, 期:4, 页:390-398
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases
研究领域[WOS]: Infectious Diseases
关键词[WOS]: HCV RNA ; LIVER ; IMMUNOASSAY ; ASSAY
英文摘要:

Response-guided therapy is of limited use in developing countries because hepatitis C virus RNA detection by sensitive molecular methods is time- and labor-consuming and expensive. We evaluated early predictive efficacy of serum hepatitis C virus core antigen kinetics on sustained virologic response in patients with genotype 1 hepatitis C virus during pegylated interferon plus ribavirin treatment. For 478 patients recruited, hepatitis C virus RNAs were detected at baseline, and at weeks 4, 12, 24, 48, and 72 using Cobas TaqMan. Architect hepatitis C virus core antigen was performed at baseline, and weeks 4 and 12. Predictive values of hepatitis C virus core antigen on sustained virologic response were compared to hepatitis C virus RNA. In the first 12 weeks after treatment initiation the dynamic patterns of serum hepatitis C virus core antigen and hepatitis C virus RNA levels were similar in sustained virologic response, relapse, and null response patients groups. Although areas under the receiver operating characteristics curves of hepatitis C virus core antigen were lower than those of hepatitis C virus RNA at the same time points, modeling analysis showed that undetectable hepatitis C virus core antigen (rapid virological response based on hepatitis C virus core antigen) had similar positive predictive value on sustained virologic response to hepatitis C virus RNA at week 4 (90.4% vs 93.3%), and hepatitis C virus core antigen decrease greater than 1 logio IU/mL (early virological response based on hepatitis C virus core antigen) had similar negative predictive value to hepatitis C virus RNA at week 12 (94.1% vs 95.2%). Analysis on the validation group demonstrated a positive predictivevalue of 97.5% in rapid virological response based on hepatitis C virus core antigen and a negative predictive value of 100% in early virological response based on hepatitis C virus core antigen. In conclusion, hepatitis C virus core antigen is comparable to hepatitis C virus RNA in predicting sustained virologic response of chronic genotype 1 hepatitis C virus infected patients, and can be used to guide anti-hepatitis C virus treatment, especially in resource-limited areas. (C) 2015 Elsevier Editora Ltda. All rights reserved.

语种: 英语
所属项目编号: 2012ZX10002-003 ; 2012ZX09303-019 ; 7122191
项目资助者: National S&amp ; T Major Project for Infectious Diseases Control ; National Major S&amp ; T Special Project for "Significant New Drugs Development" ; Beijing Natural Science Foundation
WOS记录号: WOS:000358803200008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66048
Appears in Collections:北京大学第二临床医学院_北京大学肝病研究所_期刊论文

Files in This Item:

There are no files associated with this item.


作者单位: Peking Univ, Peoples Hosp, Inst Hepatol, Beijing Key Lab Hepatitis C & Immunotherapy Liver, Beijing 100871, Peoples R China

Recommended Citation:
Feng, Bo,Yang, Rui-Feng,Zhang, Hai-Ying,et al. Early predictive efficacy of core antigen on antiviral outcomes in genotype 1 hepatitis C virus infected patients[J]. BRAZILIAN JOURNAL OF INFECTIOUS DISEASES,2015,19(4):390-398.
Service
Recommend this item
Sava as my favorate item
Show this item's statistics
Export Endnote File
Google Scholar
Similar articles in Google Scholar
[Feng, Bo]'s Articles
[Yang, Rui-Feng]'s Articles
[Zhang, Hai-Ying]'s Articles
CSDL cross search
Similar articles in CSDL Cross Search
[Feng, Bo]‘s Articles
[Yang, Rui-Feng]‘s Articles
[Zhang, Hai-Ying]‘s Articles
Related Copyright Policies
Null
Social Bookmarking
Add to CiteULike Add to Connotea Add to Del.icio.us Add to Digg Add to Reddit

Items in IR are protected by copyright, with all rights reserved, unless otherwise indicated.

 

 

Valid XHTML 1.0!
Copyright © 2007-2017  北京大学医学部 - Feedback
Powered by CSpace