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学科主题基础医学
Brain opioid-receptors are involved in mediating peripheral electric stimulation-induced inhibition of morphine conditioned place preference in rats
Shi, XD; Ren, W; Wang, GB; Luo, F; Han, JS; Cui, CL
关键词conditioned place preference craving peripheral electric stimulation opioid receptor
刊名BRAIN RESEARCH
2003-08-15
DOI10.1016/S0006-8993(03)02798-7
981期:1-2页:23-29
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]DIFFERENT FREQUENCIES ; REWARD ; ELECTROACUPUNCTURE ; ACUPUNCTURE ; BLOCKADE ; SUPPRESSION ; EXPRESSION ; DYNORPHIN ; ADDICTION ; MICE
英文摘要

Conditioned place preference (CPP) paradigm has been suggested as one of the animal models for drug craving. The present study was performed to examine the effect of 100 Hz peripheral electric stimulation (PES) on the expression of morphine-induced CPP. Rats were trained with morphine for 4 days to establish the CPP paradigm in a three-chamber ′unbiased′ apparatus. Morphine-induced CPP was maintained up to 4 weeks when tests were given once a week. PES of 100 Hz administered 30 min a day for 3 days significantly attenuated morphine-induced CPP (P<0.01). I.c.v. injection of the delta-opioid receptor antagonist naltrindole (NTI) or the kappa-antagonist norbinaltorphimine (nor-BNI) but not the mu-antagonist Cyclic D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP), completely blocked the inhibitory effect of 100 Hz PES on the expression of morphine-induced CPP (P<0.05-0.01). These results indicate that the anti-craving effects induced by repeated PES of 100 Hz is mediated by the activation of supra-segmental delta- and kappa-opioid receptors in the central nervous system. (C) 2003 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000184864700003
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被引频次:25[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66049
专题北京大学基础医学院_神经生物学系
作者单位Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China
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Shi, XD,Ren, W,Wang, GB,et al. Brain opioid-receptors are involved in mediating peripheral electric stimulation-induced inhibition of morphine conditioned place preference in rats[J]. BRAIN RESEARCH,2003,981(1-2):23-29.
APA Shi, XD,Ren, W,Wang, GB,Luo, F,Han, JS,&Cui, CL.(2003).Brain opioid-receptors are involved in mediating peripheral electric stimulation-induced inhibition of morphine conditioned place preference in rats.BRAIN RESEARCH,981(1-2),23-29.
MLA Shi, XD,et al."Brain opioid-receptors are involved in mediating peripheral electric stimulation-induced inhibition of morphine conditioned place preference in rats".BRAIN RESEARCH 981.1-2(2003):23-29.
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