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学科主题: 基础医学
题名:
Brain opioid-receptors are involved in mediating peripheral electric stimulation-induced inhibition of morphine conditioned place preference in rats
作者: Shi, XD; Ren, W; Wang, GB; Luo, F; Han, JS; Cui, CL
关键词: conditioned place preference ; craving ; peripheral electric stimulation ; opioid receptor
刊名: BRAIN RESEARCH
发表日期: 2003-08-15
DOI: 10.1016/S0006-8993(03)02798-7
卷: 981, 期:1-2, 页:23-29
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: DIFFERENT FREQUENCIES ; REWARD ; ELECTROACUPUNCTURE ; ACUPUNCTURE ; BLOCKADE ; SUPPRESSION ; EXPRESSION ; DYNORPHIN ; ADDICTION ; MICE
英文摘要:

Conditioned place preference (CPP) paradigm has been suggested as one of the animal models for drug craving. The present study was performed to examine the effect of 100 Hz peripheral electric stimulation (PES) on the expression of morphine-induced CPP. Rats were trained with morphine for 4 days to establish the CPP paradigm in a three-chamber ′unbiased′ apparatus. Morphine-induced CPP was maintained up to 4 weeks when tests were given once a week. PES of 100 Hz administered 30 min a day for 3 days significantly attenuated morphine-induced CPP (P<0.01). I.c.v. injection of the delta-opioid receptor antagonist naltrindole (NTI) or the kappa-antagonist norbinaltorphimine (nor-BNI) but not the mu-antagonist Cyclic D-Phe-Cys-Tyr-D-Trp-Arg-Thr-Pen-Thr-NH2 (CTAP), completely blocked the inhibitory effect of 100 Hz PES on the expression of morphine-induced CPP (P<0.05-0.01). These results indicate that the anti-craving effects induced by repeated PES of 100 Hz is mediated by the activation of supra-segmental delta- and kappa-opioid receptors in the central nervous system. (C) 2003 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000184864700003
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66049
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: Peking Univ, Neurosci Res Inst, Beijing 100083, Peoples R China

Recommended Citation:
Shi, XD,Ren, W,Wang, GB,et al. Brain opioid-receptors are involved in mediating peripheral electric stimulation-induced inhibition of morphine conditioned place preference in rats[J]. BRAIN RESEARCH,2003,981(1-2):23-29.
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