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学科主题药学
Duality of effect of La3+ on mitochondrial permeability transition pore depending on the concentration
Dong, Shuai1,2; Zhao, Yuebin1,2; Liu, Huixue1,2; Yang, Xiaoda1,2; Wang, Kui1,2
关键词Lanthanum ion Mitochondria Calcium ion Permeability transition pore
刊名BIOMETALS
2009-12-01
DOI10.1007/s10534-009-9244-1
22期:6页:917-926
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
研究领域[WOS]Biochemistry & Molecular Biology
关键词[WOS]RAT-LIVER MITOCHONDRIA ; CYCLOSPORINE-A ; MEMBRANE-PERMEABILITY ; CURCUMIN DERIVATIVES ; BRAIN MITOCHONDRIA ; INNER MEMBRANE ; CYTOCHROME-C ; CALCIUM ; CA2+ ; MECHANISM
英文摘要

In order to explore the role of mitochondria in proliferation promotion and/or apoptosis induction of lanthanum, the mutual influences between La3+ and Ca2+ on mitochondrial permeability transition pore (PTP) opening were investigated with isolated mitochondria from rat liver. The experimental results revealed that La3+ influence the state of mitochondria in a concentration-dependent biphasic manner. La3+ in nanomolar concentrations, acting as a Ca2+ analog, entered mitochondrial matrix via the RuR sensitive Ca2+ channel and elevated ROS level, leading to opening of PTP indicated by mitochondrial swelling, reduction of Delta I-m and cytochrome c release. Inhibition of PTP with 10 mu M CsA attenuated the effects of La3+. However, micromolar concentrations La3+ acted mainly as a Ca2+ antagonist, inhibiting PTP opening induced by Ca2+. We postulated that this action of La3+ on mitochondria through interaction with Ca2+ might be involved in the proliferation-promoting and apoptosis induction by La3+.

语种英语
所属项目编号20637010 ; 20671008
资助者National Natural Science Foundation of China ; National Natural Science Foundation of China
WOS记录号WOS:000271748400006
Citation statistics
Cited Times:10[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66064
Collection北京大学药学院_化学生物学系
作者单位1.Peking Univ, Sch Pharmaceut Sci, Dept Biol Chem, Beijing 100083, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drug, Beijing 100083, Peoples R China
Recommended Citation
GB/T 7714
Dong, Shuai,Zhao, Yuebin,Liu, Huixue,et al. Duality of effect of La3+ on mitochondrial permeability transition pore depending on the concentration[J]. BIOMETALS,2009,22(6):917-926.
APA Dong, Shuai,Zhao, Yuebin,Liu, Huixue,Yang, Xiaoda,&Wang, Kui.(2009).Duality of effect of La3+ on mitochondrial permeability transition pore depending on the concentration.BIOMETALS,22(6),917-926.
MLA Dong, Shuai,et al."Duality of effect of La3+ on mitochondrial permeability transition pore depending on the concentration".BIOMETALS 22.6(2009):917-926.
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