IR@PKUHSC  > 北京大学基础医学院
学科主题基础医学
Changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010
Mao, Yuanli1; Cui, Enbo1; Bao, Chunmei1; Liu, Zhenhong1; Chen, Suming1; Zhang, Juling1; Wang, Huan1; Zhang, Chenglong1; Zou, Jing2; Klena, John D.3; Zhu, Baoli2; Qu, Fen1; Wang, Zhiyun2
关键词Shigellosis Shigella Serotype Beijing hospital
刊名GUT PATHOGENS
2013-08-07
DOI10.1186/1757-4749-5-21
5
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology ; Microbiology
研究领域[WOS]Gastroenterology & Hepatology ; Microbiology
关键词[WOS]POPULATION-BASED SURVEILLANCE ; BACILLARY DYSENTERY ; VACCINE DEVELOPMENT ; DISEASE BURDEN ; FLEXNERI 4C ; DIARRHEA ; STRAIN ; INFECTIONS ; PATTERNS ; CHINA
英文摘要

Shigella species are a common cause of acute diarrheal disease in China. In this study, we characterized the changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010. A total of 5999 Shigella strains were isolated and serotyped from the 302nd Hospital in Beijing. The annual number of Shigella isolates reached a peak (n = 1192; 19.84%) in 1996 and then decreased annually, reaching the lowest point (n = 24; 0.41%) in 2010. S. flexneri 2a and S. sonnei were the most frequently isolated Shigella, with their respective isolates making up 53.3% and 27.6% of the total. Isolates of S. flexneri 4c, 4a, and x made up 3% respectively of the total isolates. Significant decreases in percentage of S. flexneri over time were observed. S. sonnei surpassed S. flexneri 2a as the predominant serotype in 2000. Most isolates were recovered from July to September; 13.6% of the isolates were recovered from children aged 0 to 5 years, and 16% were recovered from those aged 21 to 25 years. S. flexneri 2a and 5 were recovered mostly from males (33.41%, p < 0.001; and 0.46%, p < 0.001%; respectively), whereas S. flexneri 2b and 6, and S. sonnei were most often isolated from females. Continuous monitoring of Shigella showed that all 4 species and 27 serotypes were present in Beijing, China, during the study period. The emergence of S. sonnei and the overall decreasing isolation rate of Shigella in Beijing can potentially aid in the development of vaccine and control strategies for shigellosis in the city.

语种英语
WOS记录号WOS:000323005100001
项目编号BWS11C073
资助机构Chinese Military Medical and Technology Twelfth Five-Year Science and Research Key Program Fund
引用统计
被引频次:11[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66065
专题北京大学基础医学院
作者单位1.302nd Hosp Peoples Liberat Army, Clin Diagnost Ctr, Beijing 100039, Peoples R China
2.Chinese Acad Sci, Inst Microbiol, Beijing 100101, Peoples R China
3.Peking Univ, Sch Basic Med Sci, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Mao, Yuanli,Cui, Enbo,Bao, Chunmei,et al. Changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010[J]. GUT PATHOGENS,2013,5.
APA Mao, Yuanli.,Cui, Enbo.,Bao, Chunmei.,Liu, Zhenhong.,Chen, Suming.,...&Wang, Zhiyun.(2013).Changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010.GUT PATHOGENS,5.
MLA Mao, Yuanli,et al."Changing trends and serotype distribution of Shigella species in Beijing from 1994 to 2010".GUT PATHOGENS 5(2013).
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