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Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy
Cai, Defu1,2,3; Gao, Wei2; He, Bing2; Dai, Wenbing2; Zhang, Hua2; Wang, Xueqing2; Wang, Jiancheng2; Zhang, Xuan2; Zhang, Qiang2
关键词Hydrophobic penetration peptide Nanomedicine Liposome Drug delivery PFVYLI
刊名BIOMATERIALS
2014-02-01
DOI10.1016/j.biomaterials.2013.11.088
35期:7页:2283-2294
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]STERICALLY STABILIZED LIPOSOMES ; ARGININE-RICH PEPTIDES ; DRUG-DELIVERY ; INTRACELLULAR DELIVERY ; POLYMERIC MICELLES ; TARGETED THERAPY ; CELLULAR UPTAKE ; NANOPARTICLE ; SEQUENCE ; CELLS
英文摘要

Based on the hydrophobic interaction with biomembranes, PFVYLI (PFV), a hydrophobic penetration peptide (HPP), was initially introduced to modify doxorubicin-loaded stealth-sustained liposomes (PFV-SSLs-DOX) against different breast cancer cell phenotypes irrespective of their receptor expression or antigen presence. The physicochemical characteristics of PFV-SSLs were determined with approximately 100 nm size, satisfactory distribution and high encapsulation. In addition, drug release experiments demonstrated that modification with PFV has a negligible influence on the release profile of liposomes. Surface plasmon resonance (SPR) analysis revealed that PFV-modified liposomes could increase the binding proportion of PFV-SSLs with a model cell membrane. It was demonstrated that modification with PFV highly facilitated the intracellular delivery of DOX-loaded liposomes and enhanced cytotoxicity via a hydrophobic interaction. An endocytosis inhibition assay revealed a combination of cellular internalization mechanisms for PFV-SSLs involving lipid raft and clathrin-mediated endocytosis in a temperature-dependent manner. The PFV-modified liposomes displayed more lasting accumulation in the tumor and better tumor growth inhibition with relatively low systemic and cardiac toxicity. In conclusion, PFV-SSLs might be a promising delivery system for the delivery of different therapeutic or imaging agents to heterogeneous tumors. More significantly, this study provides a new perspective on developing HPP-modified drug delivery system for antitumor therapy. (C) 2013 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000331502300022
项目编号81130059 ; 2009CB930300 ; BMU20110263
资助机构National Natural Science Foundation of China ; National Research Fund for Fundamental Key Project ; Innovation Team of Ministry of Education
引用统计
被引频次:42[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66066
专题北京大学药学院
北京大学基础医学院
北京大学药学院_药剂学系
北京大学第三临床医学院_心血管内科
作者单位1.ShenYang Pharmaceut Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Shenyang 110016, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Qiqihar Med Univ, Inst Med & Drug Res, Qiqihar 161006, Peoples R China
推荐引用方式
GB/T 7714
Cai, Defu,Gao, Wei,He, Bing,et al. Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy[J]. BIOMATERIALS,2014,35(7):2283-2294.
APA Cai, Defu.,Gao, Wei.,He, Bing.,Dai, Wenbing.,Zhang, Hua.,...&Zhang, Qiang.(2014).Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy.BIOMATERIALS,35(7),2283-2294.
MLA Cai, Defu,et al."Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy".BIOMATERIALS 35.7(2014):2283-2294.
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