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学科主题: 药学
题名:
Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy
作者: Cai, Defu1,2,3; Gao, Wei2; He, Bing2; Dai, Wenbing2; Zhang, Hua2; Wang, Xueqing2; Wang, Jiancheng2; Zhang, Xuan2; Zhang, Qiang2
关键词: Hydrophobic penetration peptide ; Nanomedicine ; Liposome ; Drug delivery ; PFVYLI
刊名: BIOMATERIALS
发表日期: 2014-02-01
DOI: 10.1016/j.biomaterials.2013.11.088
卷: 35, 期:7, 页:2283-2294
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]: Engineering ; Materials Science
关键词[WOS]: STERICALLY STABILIZED LIPOSOMES ; ARGININE-RICH PEPTIDES ; DRUG-DELIVERY ; INTRACELLULAR DELIVERY ; POLYMERIC MICELLES ; TARGETED THERAPY ; CELLULAR UPTAKE ; NANOPARTICLE ; SEQUENCE ; CELLS
英文摘要:

Based on the hydrophobic interaction with biomembranes, PFVYLI (PFV), a hydrophobic penetration peptide (HPP), was initially introduced to modify doxorubicin-loaded stealth-sustained liposomes (PFV-SSLs-DOX) against different breast cancer cell phenotypes irrespective of their receptor expression or antigen presence. The physicochemical characteristics of PFV-SSLs were determined with approximately 100 nm size, satisfactory distribution and high encapsulation. In addition, drug release experiments demonstrated that modification with PFV has a negligible influence on the release profile of liposomes. Surface plasmon resonance (SPR) analysis revealed that PFV-modified liposomes could increase the binding proportion of PFV-SSLs with a model cell membrane. It was demonstrated that modification with PFV highly facilitated the intracellular delivery of DOX-loaded liposomes and enhanced cytotoxicity via a hydrophobic interaction. An endocytosis inhibition assay revealed a combination of cellular internalization mechanisms for PFV-SSLs involving lipid raft and clathrin-mediated endocytosis in a temperature-dependent manner. The PFV-modified liposomes displayed more lasting accumulation in the tumor and better tumor growth inhibition with relatively low systemic and cardiac toxicity. In conclusion, PFV-SSLs might be a promising delivery system for the delivery of different therapeutic or imaging agents to heterogeneous tumors. More significantly, this study provides a new perspective on developing HPP-modified drug delivery system for antitumor therapy. (C) 2013 Elsevier Ltd. All rights reserved.

语种: 英语
所属项目编号: 81130059 ; 2009CB930300 ; BMU20110263
项目资助者: National Natural Science Foundation of China ; National Research Fund for Fundamental Key Project ; Innovation Team of Ministry of Education
WOS记录号: WOS:000331502300022
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66066
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.ShenYang Pharmaceut Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Shenyang 110016, Peoples R China
2.Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Qiqihar Med Univ, Inst Med & Drug Res, Qiqihar 161006, Peoples R China

Recommended Citation:
Cai, Defu,Gao, Wei,He, Bing,et al. Hydrophobic penetrating peptide PFVYLI-modified stealth liposomes for doxorubicin delivery in breast cancer therapy[J]. BIOMATERIALS,2014,35(7):2283-2294.
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