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IR@PKUHSC  > 北京大学第三临床医学院  > 超声诊断科  > 期刊论文
学科主题: 临床医学
题名:
Quantum-dot-modified microbubbles with bi-mode imaging capabilities
作者: Ke, Hengte2; Xing, Zhanwen1,2; Zhao, Bo1; Wang, Jinrui; Liu, Jibin3; Guo, Caixin2; Yue, Xiuli2; Liu, Shaoqin2; Tang, Zhiyong4; Dai, Zhifei2
刊名: NANOTECHNOLOGY
发表日期: 2009-10-21
DOI: 10.1088/0957-4484/20/42/425105
卷: 20, 期:42
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]: Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]: ULTRASOUND CONTRAST AGENTS ; DIAGNOSTIC ULTRASOUND ; COATED MICROBUBBLES ; DELIVERY ; CELLS ; SONOPORATION ; NANOCRYSTALS ; NANOPARTICLE ; DESTRUCTION ; FUTURE
英文摘要:

The aim of this paper was to develop a novel bi-mode ultrasound/fluorescent imaging agent through stepwise layer-by-layer deposition of poly(allylamine hydrochloride) (PAH) and CdTe quantum dots (QDs) onto ST68 microbubbles (MBs) produced by sonication of a mixture of surfactants (Span 60 and Tween 80). The experiments using photoluminescence spectroscopy and confocal laser scanning microscopy confirmed that CdTe nanoparticles were successfully adsorbed on the outer surface of the MBs. The static light scattering measurements showed that size distributions of MBs before and after QD deposition met the size requirements for clinical application. The in vitro and in vivo ultrasonography indicated that the QD-modified MBs maintained good contrast enhancement properties as the original MBs. Furthermore, the in vitro ultrasound-targeted microbubble destruction (UTMD) experiment of the QD-MB composites was carried out to validate the ability of MBs to deliver QDs for fluorescent imaging. The results showed that the QD-modified MBs not only maintained the capability of ultrasound imaging, but also could be used as a targeted-drug controlled-release system to deliver the QDs for cell and tissue fluorescent imaging by UTMD. The novel dual-functional imaging agent has potential for a variety of biological and medical applications.

语种: 英语
所属项目编号: NSFC-30970829 ; 2007AA03Z316 ; 707021 ; HIT-2008QN06
项目资助者: National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Cultivation Fund of the Key Scientific and Technical Innovation Project, ; Ministry of Education of China ; State Key Lab of Urban Water Resource and Environment
WOS记录号: WOS:000270219800005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66068
Appears in Collections:北京大学第三临床医学院_超声诊断科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
2.Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Biox Ctr, Nanobiotechnol Ctr, Harbin 150001, Peoples R China
3.Thomas Jefferson Univ Hosp, Ultrasound Res & Educ Inst, Philadelphia, PA 19107 USA
4.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China

Recommended Citation:
Ke, Hengte,Xing, Zhanwen,Zhao, Bo,et al. Quantum-dot-modified microbubbles with bi-mode imaging capabilities[J]. NANOTECHNOLOGY,2009,20(42).
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