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学科主题临床医学
Quantum-dot-modified microbubbles with bi-mode imaging capabilities
Ke, Hengte2; Xing, Zhanwen1,2; Zhao, Bo1; Wang, Jinrui; Liu, Jibin3; Guo, Caixin2; Yue, Xiuli2; Liu, Shaoqin2; Tang, Zhiyong4; Dai, Zhifei2
刊名NANOTECHNOLOGY
2009-10-21
DOI10.1088/0957-4484/20/42/425105
20期:42
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Nanoscience & Nanotechnology ; Materials Science, Multidisciplinary ; Physics, Applied
研究领域[WOS]Science & Technology - Other Topics ; Materials Science ; Physics
关键词[WOS]ULTRASOUND CONTRAST AGENTS ; DIAGNOSTIC ULTRASOUND ; COATED MICROBUBBLES ; DELIVERY ; CELLS ; SONOPORATION ; NANOCRYSTALS ; NANOPARTICLE ; DESTRUCTION ; FUTURE
英文摘要

The aim of this paper was to develop a novel bi-mode ultrasound/fluorescent imaging agent through stepwise layer-by-layer deposition of poly(allylamine hydrochloride) (PAH) and CdTe quantum dots (QDs) onto ST68 microbubbles (MBs) produced by sonication of a mixture of surfactants (Span 60 and Tween 80). The experiments using photoluminescence spectroscopy and confocal laser scanning microscopy confirmed that CdTe nanoparticles were successfully adsorbed on the outer surface of the MBs. The static light scattering measurements showed that size distributions of MBs before and after QD deposition met the size requirements for clinical application. The in vitro and in vivo ultrasonography indicated that the QD-modified MBs maintained good contrast enhancement properties as the original MBs. Furthermore, the in vitro ultrasound-targeted microbubble destruction (UTMD) experiment of the QD-MB composites was carried out to validate the ability of MBs to deliver QDs for fluorescent imaging. The results showed that the QD-modified MBs not only maintained the capability of ultrasound imaging, but also could be used as a targeted-drug controlled-release system to deliver the QDs for cell and tissue fluorescent imaging by UTMD. The novel dual-functional imaging agent has potential for a variety of biological and medical applications.

语种英语
WOS记录号WOS:000270219800005
项目编号NSFC-30970829 ; 2007AA03Z316 ; 707021 ; HIT-2008QN06
资助机构National Natural Science Foundation of China ; National High Technology Research and Development Program of China ; Cultivation Fund of the Key Scientific and Technical Innovation Project, ; Ministry of Education of China ; State Key Lab of Urban Water Resource and Environment
引用统计
被引频次:34[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66068
专题北京大学第三临床医学院_超声诊断科
作者单位1.Peking Univ, Hosp 3, Dept Ultrasonog, Beijing 100083, Peoples R China
2.Harbin Inst Technol, State Key Lab Urban Water Resources & Environm, Biox Ctr, Nanobiotechnol Ctr, Harbin 150001, Peoples R China
3.Thomas Jefferson Univ Hosp, Ultrasound Res & Educ Inst, Philadelphia, PA 19107 USA
4.Natl Ctr Nanosci & Technol, Beijing 100190, Peoples R China
推荐引用方式
GB/T 7714
Ke, Hengte,Xing, Zhanwen,Zhao, Bo,et al. Quantum-dot-modified microbubbles with bi-mode imaging capabilities[J]. NANOTECHNOLOGY,2009,20(42).
APA Ke, Hengte.,Xing, Zhanwen.,Zhao, Bo.,Wang, Jinrui.,Liu, Jibin.,...&Dai, Zhifei.(2009).Quantum-dot-modified microbubbles with bi-mode imaging capabilities.NANOTECHNOLOGY,20(42).
MLA Ke, Hengte,et al."Quantum-dot-modified microbubbles with bi-mode imaging capabilities".NANOTECHNOLOGY 20.42(2009).
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