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学科主题: 临床医学
题名:
Renal protective effects of blocking the intrarenal renin-angiotensin system: Angiotensin II type I receptor antagonist compared with angiotensin-converting enzyme inhibitor
作者: Zhou, A; Yu, L; Li, JZ; Zhang, JF; Wang, HY
关键词: renin-angiotensin system ; nephrotic syndrome ; angiotensin II type I receptor antagonist ; angiotensin-converting enzyme inhibitor
刊名: HYPERTENSION RESEARCH
发表日期: 2000-07-01
卷: 23, 期:4, 页:391-397
收录类别: ISTP ; SCI
文章类型: Proceedings Paper
WOS标题词: Science & Technology
类目[WOS]: Peripheral Vascular Disease
研究领域[WOS]: Cardiovascular System & Cardiology
关键词[WOS]: PROXIMAL TUBULAR CELLS ; MESANGIAL CELLS ; PROGRESSION ; COLLAGEN ; PROTEIN ; INJURY ; RATS ; NEPHROPATHY ; EXPRESSION ; DISEASE
英文摘要:

The present study compared renoprotective effects of angiotensin II type I receptor antagonist (AT(1)RA) with angiotensin converting enzyme inhibitor (ACEI), and their influence on the renin-angiotensin-system (RAS). Experimental nephrotic syndrome was induced in SD rats by repeated peritoneal injections of puromycin. Twenty-eight rats were randomly divided into four groups: normal control, nephrotic control, ACEI-treated, and AT(1)RA-treated groups. Serum, urine, and renal tissue were collected for study at the end of 12 weeks. Compared with those of the nephrotic control group, urinary protein was less and renal function was better in both treated groups. The glomerular and interstitial damage indexes of both ACEI- and AT1RA-treated rats were lower than those of nephrotic control rats, with no significant difference observed between the two treated groups. Local renal ACE activity and angiotensin II concentration were elevated in nephrotic rats (p < 0.01). However, there is no significant difference in circulating RAS, renal tissue renin, and aldosterone between the normal control and nephrotic control rats. As expected, enalapril inhibited the local renal ACE activity and significantly decreased angiotensin II (p < 0.01). Intrarenal ACE activity and angiotensin concentration returned to normal levels after treatment with irbesartan (p < 0.01). In conclusion, AT1RA and ACEI have comparable renal protective effects, and these protective effects were associated with the inhibition of intrarenal ANG II.

语种: 英语
WOS记录号: WOS:000088207600016
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66073
Appears in Collections:北京大学第一临床医学院_肾脏内科_期刊论文

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作者单位: Beijing Med Univ, Inst Nephrol, Beijing 100083, Peoples R China

Recommended Citation:
Zhou, A,Yu, L,Li, JZ,et al. Renal protective effects of blocking the intrarenal renin-angiotensin system: Angiotensin II type I receptor antagonist compared with angiotensin-converting enzyme inhibitor[J]. HYPERTENSION RESEARCH,2000,23(4):391-397.
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