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学科主题临床医学
Renal protective effects of blocking the intrarenal renin-angiotensin system: Angiotensin II type I receptor antagonist compared with angiotensin-converting enzyme inhibitor
Zhou, A; Yu, L; Li, JZ; Zhang, JF; Wang, HY
关键词renin-angiotensin system nephrotic syndrome angiotensin II type I receptor antagonist angiotensin-converting enzyme inhibitor
刊名HYPERTENSION RESEARCH
2000-07-01
23期:4页:391-397
收录类别ISTP ; SCI
文章类型Proceedings Paper
WOS标题词Science & Technology
类目[WOS]Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology
关键词[WOS]PROXIMAL TUBULAR CELLS ; MESANGIAL CELLS ; PROGRESSION ; COLLAGEN ; PROTEIN ; INJURY ; RATS ; NEPHROPATHY ; EXPRESSION ; DISEASE
英文摘要

The present study compared renoprotective effects of angiotensin II type I receptor antagonist (AT(1)RA) with angiotensin converting enzyme inhibitor (ACEI), and their influence on the renin-angiotensin-system (RAS). Experimental nephrotic syndrome was induced in SD rats by repeated peritoneal injections of puromycin. Twenty-eight rats were randomly divided into four groups: normal control, nephrotic control, ACEI-treated, and AT(1)RA-treated groups. Serum, urine, and renal tissue were collected for study at the end of 12 weeks. Compared with those of the nephrotic control group, urinary protein was less and renal function was better in both treated groups. The glomerular and interstitial damage indexes of both ACEI- and AT1RA-treated rats were lower than those of nephrotic control rats, with no significant difference observed between the two treated groups. Local renal ACE activity and angiotensin II concentration were elevated in nephrotic rats (p < 0.01). However, there is no significant difference in circulating RAS, renal tissue renin, and aldosterone between the normal control and nephrotic control rats. As expected, enalapril inhibited the local renal ACE activity and significantly decreased angiotensin II (p < 0.01). Intrarenal ACE activity and angiotensin concentration returned to normal levels after treatment with irbesartan (p < 0.01). In conclusion, AT1RA and ACEI have comparable renal protective effects, and these protective effects were associated with the inhibition of intrarenal ANG II.

语种英语
WOS记录号WOS:000088207600016
引用统计
被引频次:16[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66073
专题北京大学第一临床医学院_肾脏内科
作者单位Beijing Med Univ, Inst Nephrol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Zhou, A,Yu, L,Li, JZ,et al. Renal protective effects of blocking the intrarenal renin-angiotensin system: Angiotensin II type I receptor antagonist compared with angiotensin-converting enzyme inhibitor[J]. HYPERTENSION RESEARCH,2000,23(4):391-397.
APA Zhou, A,Yu, L,Li, JZ,Zhang, JF,&Wang, HY.(2000).Renal protective effects of blocking the intrarenal renin-angiotensin system: Angiotensin II type I receptor antagonist compared with angiotensin-converting enzyme inhibitor.HYPERTENSION RESEARCH,23(4),391-397.
MLA Zhou, A,et al."Renal protective effects of blocking the intrarenal renin-angiotensin system: Angiotensin II type I receptor antagonist compared with angiotensin-converting enzyme inhibitor".HYPERTENSION RESEARCH 23.4(2000):391-397.
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