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学科主题临床医学
Biological features of novel avian influenza A (H7N9) virus
Zhou, Jianfang1; Wang, Dayan1; Gao, Rongbao1; Zhao, Baihui2; Song, Jingdong1; Qi, Xian3; Zhang, Yanjun4; Shi, Yonglin5; Yang, Lei1; Zhu, Wenfei1; Bai, Tian1; Qin, Kun1; Lan, Yu1; Zou, Shumei1; Guo, Junfeng1; Dong, Jie1; Dong, Libo1; Zhang, Ye1; Wei, Hejiang1; Li, Xiaodan1; Lu, Jian1; Liu, Liqi1; Zhao, Xiang1; Li, Xiyan1; Huang, Weijuan1; Wen, Leying1; Bo, Hong1; Xin, Li1; Chen, Yongkun1; Xu, Cuilin1; Pei, Yuquan6; Yang, Yue6; Zhang, Xiaodong6; Wang, Shiwen1; Feng, Zijian7; Han, Jun7; Yang, Weizhong7; Gao, George F.7; Wu, Guizhen1; Li, Dexin1; Wang, Yu7; Shu, Yuelong1
刊名NATURE
2013-07-25
DOI10.1038/nature12379
499期:7459页:500-+
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; INCREASED EXPRESSION ; INFECTION ; BINDING ; CELLS ; HEMAGGLUTININ ; TRANSMISSION ; SPECIFICITY ; ADAPTATION ; FERRETS
英文摘要

Human infection associated with a novel reassortant avian influenza H7N9 virus has recently been identified in China(1). A total of 132 confirmed cases and 39 deaths have been reported(2). Most patients presented with severe pneumonia and acute respiratory distress syndrome(3,4). Although the first epidemic has subsided, the presence of a natural reservoir and the disease severity highlight the need to evaluate its risk on human public health and to understand the possible pathogenesis mechanism. Here we show that the emerging H7N9 avian influenza virus poses a potentially high risk to humans. We discover that the H7N9 virus can bind to both avian-type (alpha 2,3-linked sialic acid) and human-type (alpha 2,6-linked sialic acid) receptors. It can invade epithelial cells in the human lower respiratory tract and type II pneumonocytes in alveoli, and replicated efficiently in ex vivo lung and trachea explant culture and several mammalian cell lines. In acute serum samples of H7N9-infected patients, increased levels of the chemokines and cytokines IP-10, MIG, MIP-1 beta, MCP-1, IL-6, IL-8 and IFN-alpha were detected. We note that the human population is naive to the H7N9 virus, and current seasonal vaccination could not provide protection.

语种英语
WOS记录号WOS:000322157900045
项目编号2011CB504704 ; KJYJ-2013-01-01 ; 2013ZX10004611
资助机构National Basic Research Program (973) of China ; National Ministry of Science and Technology ; National Mega-projects for Infectious Diseases
引用统计
被引频次:204[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66077
专题北京大学临床肿瘤学院
北京大学临床肿瘤学院_消化肿瘤内科
作者单位1.Natl Hlth & Family Planning Commiss, Key Lab Med Virol, China CDC, Nat Inst Viral Dis Control & Prevent, Beijing 102206, Peoples R China
2.Shanghai Municipal Dis Control & Prevent, Shanghai 200336, Peoples R China
3.Jiangsu Prov Dis Control & Prevent, Nanjing 210009, Jiangsu, Peoples R China
4.Zhejiang Prov Dis Control & Prevent, Hangzhou 310051, Zhejiang, Peoples R China
5.Anhui Prov Dis Control & Prevent, Hefei 230601, Peoples R China
6.Peking Univ, Canc Hosp, Key Lab Carcinogenesis & Translat Res, Beijing 100142, Peoples R China
7.Chinese Ctr Dis Control & Prevent, Beijing 102206, Peoples R China
推荐引用方式
GB/T 7714
Zhou, Jianfang,Wang, Dayan,Gao, Rongbao,et al. Biological features of novel avian influenza A (H7N9) virus[J]. NATURE,2013,499(7459):500-+.
APA Zhou, Jianfang.,Wang, Dayan.,Gao, Rongbao.,Zhao, Baihui.,Song, Jingdong.,...&Shu, Yuelong.(2013).Biological features of novel avian influenza A (H7N9) virus.NATURE,499(7459),500-+.
MLA Zhou, Jianfang,et al."Biological features of novel avian influenza A (H7N9) virus".NATURE 499.7459(2013):500-+.
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