IR@PKUHSC  > 北京大学第三临床医学院  > 耳鼻喉科
学科主题临床医学
Effects of salicylate on voltage-gated sodium channels in rat interior colliculus neurons
Liu, YX; Li, XP
关键词salicylate sodium currents inferior colliculus tinnitus patch clamp
刊名HEARING RESEARCH
2004-07-01
DOI10.1016/j.heares.2004.03.006
193期:1-2页:68-74
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Audiology & Speech-Language Pathology ; Neurosciences ; Otorhinolaryngology
研究领域[WOS]Audiology & Speech-Language Pathology ; Neurosciences & Neurology ; Otorhinolaryngology
关键词[WOS]INFERIOR COLLICULUS ; AUDITORY PATHWAY ; GUINEA-PIG ; TINNITUS ; MODEL ; MECHANISMS ; EXPRESSION ; LIDOCAINE ; SYSTEM
英文摘要

To investigate the effects of the tinnitus inducer, sodium salicylate, on voltage-gated sodium channels, we studied freshly dissociated inferior colliculus neurons of rats by the whole-cell voltage clamp method. Salicylate blocked sodium channels in concentration-dependent manner (0.1-10 mM), and the IC50 value of salicylate was estimated to be 1.43 mM after application. The sodium conductance-voltage curve did not shift along the voltage axis with salicylate application. In contrast, the steady-state sodium channel inactivation curve was shifted by about 9 mV in the hyperpolarizing direction. In addition, salicylate delayed the sodium channel recovery from inactivation by increasing the slow time constant. It was concluded that salicylate bound to the resting and inactivated sodium channels to cause blocking, with a higher affinity for the latter state. Our results suggest that salicylate causes a concentration-dependent blockade of voltage-gated sodium channels and shifts the inactivation curve to more hyperpolarized potentials, which could be related to the mechanism of salicylate-induced tinnitus. (C) 2004 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000222666000008
引用统计
被引频次:20[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66078
专题北京大学第三临床医学院_耳鼻喉科
作者单位Peking Univ, Hosp 3, Dept Otorhinolaryngol, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Liu, YX,Li, XP. Effects of salicylate on voltage-gated sodium channels in rat interior colliculus neurons[J]. HEARING RESEARCH,2004,193(1-2):68-74.
APA Liu, YX,&Li, XP.(2004).Effects of salicylate on voltage-gated sodium channels in rat interior colliculus neurons.HEARING RESEARCH,193(1-2),68-74.
MLA Liu, YX,et al."Effects of salicylate on voltage-gated sodium channels in rat interior colliculus neurons".HEARING RESEARCH 193.1-2(2004):68-74.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Liu, YX]的文章
[Li, XP]的文章
百度学术
百度学术中相似的文章
[Liu, YX]的文章
[Li, XP]的文章
必应学术
必应学术中相似的文章
[Liu, YX]的文章
[Li, XP]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。