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Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3
Fu, Siqing2; Li, Yanfang1,4; Huang, Jie1; Liu, Tao1; Hong, Zhen1,5; Chen, Aiping1; Bast, Robert C.3; Kavanagh, John J.1; Gershenson, David M.1; Sood, Anil K.1,6,7; Hu, Wei1
关键词ovarian cancer Aurora kinases Aurora kinase inhibitors chemosensitization
刊名CANCER BIOLOGY & THERAPY
2012-09-01
DOI10.4161/cbt.21045
13期:11页:1034-1041
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Oncology
研究领域[WOS]Oncology
关键词[WOS]SUPPRESSES TUMOR-GROWTH ; HUMAN PANCREATIC-CANCER ; B-KINASE ; IN-VIVO ; SERINE/THREONINE KINASE ; CARCINOMA ; OVEREXPRESSION ; PACLITAXEL ; CISPLATIN ; VX-680
英文摘要

Aurora kinases are essential for regulation of chromosome segregation and cytokinesis during mitosis and play a role in growth and progression of human tumors, including ovarian cancer. Aurora A and Aurora B are frequently overexpressed in high-grade and low-grade ovarian cancers. Targeting Aurora kinases has great potential for improving the efficacy of chemotherapies of ovarian cancer. In this study, we investigated whether the Aurora kinase inhibitor, VE 465, can enhance the antitumor activity of carboplatin in human ovarian cancer cells. The antitumor activity of VE 465 was tested by MTT proliferative assay in multiple established human epithelial ovarian cancer cell lines of varying p53 status. VE 465 and carboplatin had a synergistic effect on cell viability in both platinum-sensitive and -resistant ovarian cancers. The growth-inhibitory effect was accompanied by reduction in expression of histone 3 and an increase in apoptosis. We conclude that VE 465 enhances the efficacy of carboplatin agents in ovarian carcinoma.

语种英语
WOS记录号WOS:000308694300008
项目编号P50 CA083639 (PP-DRP7) ; 5P30CA016672-32
资助机构Ovarian SPORE ; NIH
引用统计
被引频次:5[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66083
专题北京大学临床肿瘤学院_妇科肿瘤科
作者单位1.Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, Houston, TX 77030 USA
2.Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA
3.Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
4.Sun Yat Sen Univ, Ctr Canc, Dept Gynecol Oncol, Guangzhou 510275, Guangdong, Peoples R China
5.Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
6.Univ Texas MD Anderson Canc Ctr, Ctr RNAi & Mon Coding RNA, Houston, TX 77030 USA
7.Beijing Canc Hosp, Dept Gynecol, Beijing, Peoples R China
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Fu, Siqing,Li, Yanfang,Huang, Jie,et al. Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3[J]. CANCER BIOLOGY & THERAPY,2012,13(11):1034-1041.
APA Fu, Siqing.,Li, Yanfang.,Huang, Jie.,Liu, Tao.,Hong, Zhen.,...&Hu, Wei.(2012).Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3.CANCER BIOLOGY & THERAPY,13(11),1034-1041.
MLA Fu, Siqing,et al."Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3".CANCER BIOLOGY & THERAPY 13.11(2012):1034-1041.
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