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学科主题: 临床医学
题名:
Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3
作者: Fu, Siqing2; Li, Yanfang1,4; Huang, Jie1; Liu, Tao1; Hong, Zhen1,5; Chen, Aiping1; Bast, Robert C.3; Kavanagh, John J.1; Gershenson, David M.1; Sood, Anil K.1,6,7; Hu, Wei1
关键词: ovarian cancer ; Aurora kinases ; Aurora kinase inhibitors ; chemosensitization
刊名: CANCER BIOLOGY & THERAPY
发表日期: 2012-09-01
DOI: 10.4161/cbt.21045
卷: 13, 期:11, 页:1034-1041
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Oncology
研究领域[WOS]: Oncology
关键词[WOS]: SUPPRESSES TUMOR-GROWTH ; HUMAN PANCREATIC-CANCER ; B-KINASE ; IN-VIVO ; SERINE/THREONINE KINASE ; CARCINOMA ; OVEREXPRESSION ; PACLITAXEL ; CISPLATIN ; VX-680
英文摘要:

Aurora kinases are essential for regulation of chromosome segregation and cytokinesis during mitosis and play a role in growth and progression of human tumors, including ovarian cancer. Aurora A and Aurora B are frequently overexpressed in high-grade and low-grade ovarian cancers. Targeting Aurora kinases has great potential for improving the efficacy of chemotherapies of ovarian cancer. In this study, we investigated whether the Aurora kinase inhibitor, VE 465, can enhance the antitumor activity of carboplatin in human ovarian cancer cells. The antitumor activity of VE 465 was tested by MTT proliferative assay in multiple established human epithelial ovarian cancer cell lines of varying p53 status. VE 465 and carboplatin had a synergistic effect on cell viability in both platinum-sensitive and -resistant ovarian cancers. The growth-inhibitory effect was accompanied by reduction in expression of histone 3 and an increase in apoptosis. We conclude that VE 465 enhances the efficacy of carboplatin agents in ovarian carcinoma.

语种: 英语
所属项目编号: P50 CA083639 (PP-DRP7) ; 5P30CA016672-32
项目资助者: Ovarian SPORE ; NIH
WOS记录号: WOS:000308694300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66083
Appears in Collections:北京大学临床肿瘤学院_妇科肿瘤科_期刊论文

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作者单位: 1.Univ Texas MD Anderson Canc Ctr, Dept Gynecol Oncol & Reprod Med, Houston, TX 77030 USA
2.Univ Texas MD Anderson Canc Ctr, Dept Invest Canc Therapeut, Houston, TX 77030 USA
3.Univ Texas MD Anderson Canc Ctr, Dept Expt Therapeut, Houston, TX 77030 USA
4.Sun Yat Sen Univ, Ctr Canc, Dept Gynecol Oncol, Guangzhou 510275, Guangdong, Peoples R China
5.Univ Texas MD Anderson Canc Ctr, Dept Canc Biol, Houston, TX 77030 USA
6.Univ Texas MD Anderson Canc Ctr, Ctr RNAi & Mon Coding RNA, Houston, TX 77030 USA
7.Beijing Canc Hosp, Dept Gynecol, Beijing, Peoples R China

Recommended Citation:
Fu, Siqing,Li, Yanfang,Huang, Jie,et al. Aurora kinase inhibitor VE 465 synergistically enhances cytotoxicity of carboplatin in ovarian cancer cells through induction of apoptosis and downregulation of histone 3[J]. CANCER BIOLOGY & THERAPY,2012,13(11):1034-1041.
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