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Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection
Ding, Y-P.1; Liang, M-F.2; Ye, J-b.3; Liu, Q-h.4; Xiong, C-h.5; Long, B.6; Lin, W-b.7; Cui, N.8; Zou, Z-q.6; Song, Y-l.9; Zhang, Q-f.2; Zhang, S.2; Liu, Y-z.10; Song, G.1; Ren, Y-y.11; Li, S-h.12; Wang, Y.1; Hou, F-q.1; Yu, H.6; Ding, P.13; Ye, F.9; Li, D-X.2; Wang, G-Q.1
关键词Acute phase prognostic marker severe fever with thrombocytopenia syndrome
刊名CLINICAL MICROBIOLOGY AND INFECTION
2014-11-01
DOI10.1111/1469-0691.12636
20期:11页:O870-O878
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Infectious Diseases ; Microbiology
研究领域[WOS]Infectious Diseases ; Microbiology
关键词[WOS]THROMBOCYTOPENIA SYNDROME BUNYAVIRUS ; CONGO HEMORRHAGIC-FEVER ; TO-HUMAN TRANSMISSION ; NECROSIS-FACTOR-ALPHA ; EBOLA-VIRUS ; CYTOKINE ; CHINA ; PATHOGENESIS ; PHLEBOVIRUS ; EXPRESSION
英文摘要

SFTS virus (SFTSV) is a novel bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease that occurred in China in recent years, with an average case fatality rate of 10-12%. Intervention in the early clinical stage is the most effective measure to reduce the mortality rate of disease. To elucidate the natural course of and immune mechanisms associated with the pathogenesis of SFTSV, 59 laboratory-confirmed SFTS patients in the acute phase, who were hospitalized between October 2010 and September 2011, were enrolled in this study, and the patients sera were dynamically collected and tested for SFTSV viral RNA load, 34 cytokines or chemokines and other related laboratory parameters. All clinical diagnostic factors in the acute phase of SFTS were evaluated and assessed. The study showed that the severity of the disease in 11 (18.6%) patients was associated with abdominal pain (p 0.007; OR=21.95; 95% CI, 2.32-208.11) and gingival bleeding (p 0.001; OR=122.11; 95% CI, 6.41-2328). The IP-10, TNF-, IL-6, IL-10, granzyme B and HSP70 levels were higher over the 7-8days in severe cases, accompanied by altered AST, CK and LDH levels. HSP70 (p 0.012; OR=8.29; 95% CI, 1.58-43.40) was independently correlated with the severity of the early acute phase of SFTSV infection. The severity of SFTS can be predicted based on the presence of symptoms such as abdominal pain and gingival bleeding and on the level of HSP70 in the acute phase of the disease.

语种英语
WOS记录号WOS:000346337000015
项目编号2013ZX10002005 ; 2013ZX10004101
资助机构China Mega-Project for Infectious Diseases
引用统计
被引频次:15[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66091
专题北京大学第一临床医学院_感染疾病科
作者单位1.Xinyang Ctr Hosp, Xinyang, Peoples R China
2.PLA 154 Hosp, Xinyang, Peoples R China
3.Beijing SinoMDgene Technol Co Ltd, Beijing, Peoples R China
4.Beijing Chao Yang Hosp, Ctr Liver Dis, Beijing, Peoples R China
5.Ningxia Autonomous Reg CDC, Yinchuan, Peoples R China
6.Peking Univ, Hosp 1, Dept Infect Dis, Ctr Liver Dis, Beijing 100034, Peoples R China
7.China CDC, Natl Inst Viral Dis Control & Prevent, Key Lab Med Virol, Beijing, Peoples R China
8.Beijing Union Med Coll Hosp, Dept Resp Med, Beijing, Peoples R China
9.Beijing Chao Yang Hosp, Div Resp & Crit Care Med, Beijing, Peoples R China
10.Guangshan Cty Hosp, Xinyang, Peoples R China
11.Laizhou Peoples Hosp, Yantai, Peoples R China
12.Shang Cheng Cty Hosp, Xinyang, Peoples R China
13.Yantai Infect Dis Hosp, Yantai, Peoples R China
推荐引用方式
GB/T 7714
Ding, Y-P.,Liang, M-F.,Ye, J-b.,et al. Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection[J]. CLINICAL MICROBIOLOGY AND INFECTION,2014,20(11):O870-O878.
APA Ding, Y-P..,Liang, M-F..,Ye, J-b..,Liu, Q-h..,Xiong, C-h..,...&Wang, G-Q..(2014).Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection.CLINICAL MICROBIOLOGY AND INFECTION,20(11),O870-O878.
MLA Ding, Y-P.,et al."Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection".CLINICAL MICROBIOLOGY AND INFECTION 20.11(2014):O870-O878.
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