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学科主题: 临床医学
题名:
Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection
作者: Ding, Y-P.1; Liang, M-F.2; Ye, J-b.3; Liu, Q-h.4; Xiong, C-h.5; Long, B.6; Lin, W-b.7; Cui, N.8; Zou, Z-q.6; Song, Y-l.9; Zhang, Q-f.2; Zhang, S.2; Liu, Y-z.10; Song, G.1; Ren, Y-y.11; Li, S-h.12; Wang, Y.1; Hou, F-q.1; Yu, H.6; Ding, P.13; Ye, F.9; Li, D-X.2; Wang, G-Q.1
关键词: Acute phase ; prognostic marker ; severe fever with thrombocytopenia syndrome
刊名: CLINICAL MICROBIOLOGY AND INFECTION
发表日期: 2014-11-01
DOI: 10.1111/1469-0691.12636
卷: 20, 期:11, 页:O870-O878
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Infectious Diseases ; Microbiology
研究领域[WOS]: Infectious Diseases ; Microbiology
关键词[WOS]: THROMBOCYTOPENIA SYNDROME BUNYAVIRUS ; CONGO HEMORRHAGIC-FEVER ; TO-HUMAN TRANSMISSION ; NECROSIS-FACTOR-ALPHA ; EBOLA-VIRUS ; CYTOKINE ; CHINA ; PATHOGENESIS ; PHLEBOVIRUS ; EXPRESSION
英文摘要:

SFTS virus (SFTSV) is a novel bunyavirus that causes severe fever with thrombocytopenia syndrome (SFTS), an emerging infectious disease that occurred in China in recent years, with an average case fatality rate of 10-12%. Intervention in the early clinical stage is the most effective measure to reduce the mortality rate of disease. To elucidate the natural course of and immune mechanisms associated with the pathogenesis of SFTSV, 59 laboratory-confirmed SFTS patients in the acute phase, who were hospitalized between October 2010 and September 2011, were enrolled in this study, and the patients sera were dynamically collected and tested for SFTSV viral RNA load, 34 cytokines or chemokines and other related laboratory parameters. All clinical diagnostic factors in the acute phase of SFTS were evaluated and assessed. The study showed that the severity of the disease in 11 (18.6%) patients was associated with abdominal pain (p 0.007; OR=21.95; 95% CI, 2.32-208.11) and gingival bleeding (p 0.001; OR=122.11; 95% CI, 6.41-2328). The IP-10, TNF-, IL-6, IL-10, granzyme B and HSP70 levels were higher over the 7-8days in severe cases, accompanied by altered AST, CK and LDH levels. HSP70 (p 0.012; OR=8.29; 95% CI, 1.58-43.40) was independently correlated with the severity of the early acute phase of SFTSV infection. The severity of SFTS can be predicted based on the presence of symptoms such as abdominal pain and gingival bleeding and on the level of HSP70 in the acute phase of the disease.

语种: 英语
所属项目编号: 2013ZX10002005 ; 2013ZX10004101
项目资助者: China Mega-Project for Infectious Diseases
WOS记录号: WOS:000346337000015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66091
Appears in Collections:北京大学第一临床医学院_感染疾病科_期刊论文

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作者单位: 1.Xinyang Ctr Hosp, Xinyang, Peoples R China
2.PLA 154 Hosp, Xinyang, Peoples R China
3.Beijing SinoMDgene Technol Co Ltd, Beijing, Peoples R China
4.Beijing Chao Yang Hosp, Ctr Liver Dis, Beijing, Peoples R China
5.Ningxia Autonomous Reg CDC, Yinchuan, Peoples R China
6.Peking Univ, Hosp 1, Dept Infect Dis, Ctr Liver Dis, Beijing 100034, Peoples R China
7.China CDC, Natl Inst Viral Dis Control & Prevent, Key Lab Med Virol, Beijing, Peoples R China
8.Beijing Union Med Coll Hosp, Dept Resp Med, Beijing, Peoples R China
9.Beijing Chao Yang Hosp, Div Resp & Crit Care Med, Beijing, Peoples R China
10.Guangshan Cty Hosp, Xinyang, Peoples R China
11.Laizhou Peoples Hosp, Yantai, Peoples R China
12.Shang Cheng Cty Hosp, Xinyang, Peoples R China
13.Yantai Infect Dis Hosp, Yantai, Peoples R China

Recommended Citation:
Ding, Y-P.,Liang, M-F.,Ye, J-b.,et al. Prognostic value of clinical and immunological markers in acute phase of SFTS virus infection[J]. CLINICAL MICROBIOLOGY AND INFECTION,2014,20(11):O870-O878.
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