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High relapse rate and poor medication adherence in the Chinese population with schizophrenia: results from an observational survey in the People′s Republic of China
Xiao, Jingbo; Mi, Weifeng; Li, Lingzhi; Shi, Ying; Zhang, Hongyan
关键词schizophrenia relapse medication adherence
刊名NEUROPSYCHIATRIC DISEASE AND TREATMENT
2015
DOI10.2147/NDT.S72367
11页:1161-1167
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Psychiatry
关键词[WOS]1ST EPISODE SCHIZOPHRENIA ; RISK-FACTORS ; CONTROLLED-TRIALS ; DOUBLE-BLIND ; FOLLOW-UP ; METAANALYSIS ; PREDICTORS ; NONADHERENCE ; ANTIPSYCHOTICS ; PREVENTION
英文摘要

Background: Relapse is common in schizophrenia, and seriously impacts patients′ quality of life and social functioning. Many factors have been identified that may potentially increase the risk of relapse. This study was designed to investigate the relapse rate in the year following hospital discharge among Chinese patients with schizophrenia in the naturalistic condition, and to explore possible risk factors related to relapse.

Methods: We conducted a large, multicenter, retrospective, observational study in ten psychiatric hospitals throughout the People′s Republic of China. Nine hundred and ninety-two schizophrenic outpatients aged 18-65 years discharged from these hospitals between September 2011 and February 2012 with recovery/improvement of their condition were included in the study. Information about relapse and correlative factors during the year after discharge was collected by telephone interview using a questionnaire.

Results: Eight hundred and seventy-six of 992 eligible patients completed the telephone survey. Of these patients, 293 (33.4%) had at least one relapse within 1 year after discharge, and 165 (18.8%) were rehospitalized. In respondents′ view, the most important factor contributing to relapse was poor medication adherence (50.7%). Approximately 30% of the respondents had a negative attitude toward medication, with the impression that there was no need to take drugs at all or for a long time. Nonadherent patients (37.9%) had a relapse rate that was 2.5-fold higher than adherent patients (54.5% versus 20.7%, P<0.001). The top five risk factors associated with relapse were nonadherence to medication (odds ratio [OR] 4.602, 95% confidence interval [CI] 3.410-6.211), being without work (OR 3.275, 95% CI 2.291-4.681), poor self-care ability (OR 2.996, 95% CI 2.129-4.214), poor interpersonal skills (OR 2.635, 95% CI 1.951-3.558), and hospitalization on more than three occasions (OR 2.299, 95% CI 1.691-3.126).

Conclusion: The 1-year relapse rate after discharge in patients with schizophrenia was 33.5% in our study. The most important risk factor related to relapse was poor medication adherence, which was mainly due to patients having a negative attitude toward their medication. Lack of psychosocial support and a complicated disease history also increased the risk of relapse.

语种英语
WOS记录号WOS:000354197200001
项目编号Z121107001012039
资助机构Beijing Municipal Commission of Science and Technology Clinical Application Special Fund
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66094
专题北京大学精神卫生研究所
北京大学医学图书馆_采访编目部
北京大学精神卫生研究所_精神科
作者单位Peking Univ, Dept Psychiat, Key Lab Mental Hlth, Hosp 6,Inst Mental Hlth,Minist Hlth, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Xiao, Jingbo,Mi, Weifeng,Li, Lingzhi,et al. High relapse rate and poor medication adherence in the Chinese population with schizophrenia: results from an observational survey in the People&prime;s Republic of China[J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT,2015,11:1161-1167.
APA Xiao, Jingbo,Mi, Weifeng,Li, Lingzhi,Shi, Ying,&Zhang, Hongyan.(2015).High relapse rate and poor medication adherence in the Chinese population with schizophrenia: results from an observational survey in the People′s Republic of China.NEUROPSYCHIATRIC DISEASE AND TREATMENT,11,1161-1167.
MLA Xiao, Jingbo,et al."High relapse rate and poor medication adherence in the Chinese population with schizophrenia: results from an observational survey in the People′s Republic of China".NEUROPSYCHIATRIC DISEASE AND TREATMENT 11(2015):1161-1167.
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