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学科主题: 精神卫生
题名:
High relapse rate and poor medication adherence in the Chinese population with schizophrenia: results from an observational survey in the People′s Republic of China
作者: Xiao, Jingbo; Mi, Weifeng; Li, Lingzhi; Shi, Ying; Zhang, Hongyan
关键词: schizophrenia ; relapse ; medication adherence
刊名: NEUROPSYCHIATRIC DISEASE AND TREATMENT
发表日期: 2015
DOI: 10.2147/NDT.S72367
卷: 11, 页:1161-1167
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: 1ST EPISODE SCHIZOPHRENIA ; RISK-FACTORS ; CONTROLLED-TRIALS ; DOUBLE-BLIND ; FOLLOW-UP ; METAANALYSIS ; PREDICTORS ; NONADHERENCE ; ANTIPSYCHOTICS ; PREVENTION
英文摘要:

Background: Relapse is common in schizophrenia, and seriously impacts patients′ quality of life and social functioning. Many factors have been identified that may potentially increase the risk of relapse. This study was designed to investigate the relapse rate in the year following hospital discharge among Chinese patients with schizophrenia in the naturalistic condition, and to explore possible risk factors related to relapse.

Methods: We conducted a large, multicenter, retrospective, observational study in ten psychiatric hospitals throughout the People′s Republic of China. Nine hundred and ninety-two schizophrenic outpatients aged 18-65 years discharged from these hospitals between September 2011 and February 2012 with recovery/improvement of their condition were included in the study. Information about relapse and correlative factors during the year after discharge was collected by telephone interview using a questionnaire.

Results: Eight hundred and seventy-six of 992 eligible patients completed the telephone survey. Of these patients, 293 (33.4%) had at least one relapse within 1 year after discharge, and 165 (18.8%) were rehospitalized. In respondents′ view, the most important factor contributing to relapse was poor medication adherence (50.7%). Approximately 30% of the respondents had a negative attitude toward medication, with the impression that there was no need to take drugs at all or for a long time. Nonadherent patients (37.9%) had a relapse rate that was 2.5-fold higher than adherent patients (54.5% versus 20.7%, P<0.001). The top five risk factors associated with relapse were nonadherence to medication (odds ratio [OR] 4.602, 95% confidence interval [CI] 3.410-6.211), being without work (OR 3.275, 95% CI 2.291-4.681), poor self-care ability (OR 2.996, 95% CI 2.129-4.214), poor interpersonal skills (OR 2.635, 95% CI 1.951-3.558), and hospitalization on more than three occasions (OR 2.299, 95% CI 1.691-3.126).

Conclusion: The 1-year relapse rate after discharge in patients with schizophrenia was 33.5% in our study. The most important risk factor related to relapse was poor medication adherence, which was mainly due to patients having a negative attitude toward their medication. Lack of psychosocial support and a complicated disease history also increased the risk of relapse.

语种: 英语
所属项目编号: Z121107001012039
项目资助者: Beijing Municipal Commission of Science and Technology Clinical Application Special Fund
WOS记录号: WOS:000354197200001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66094
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: Peking Univ, Dept Psychiat, Key Lab Mental Hlth, Hosp 6,Inst Mental Hlth,Minist Hlth, Beijing 100191, Peoples R China

Recommended Citation:
Xiao, Jingbo,Mi, Weifeng,Li, Lingzhi,et al. High relapse rate and poor medication adherence in the Chinese population with schizophrenia: results from an observational survey in the People&prime;s Republic of China[J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT,2015,11:1161-1167.
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