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学科主题: 临床医学
题名:
SLCO1B1 Variants and Angiotensin Converting Enzyme Inhibitor (Enalapril) -Induced Cough: a Pharmacogenetic Study
作者: Luo, Jian-Quan1,2,3; He, Fa-Zhong1,2,3; Wang, Zhen-Min1,2,3; Sun, Ning-Ling4; Wang, Lu-Yan4; Tang, Gen-Fu5; Liu, Mou-Ze1,2,3; Li, Qing1,2,3; Chen, Xiao-Ping1,2,3; Liu, Zhao-Qian1,2,3; Zhou, Hong-Hao1,2,3; Zhang, Wei1,2,3
刊名: SCIENTIFIC REPORTS
发表日期: 2015-11-26
DOI: 10.1038/srep17253
卷: 5
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: TRANSPORTING POLYPEPTIDE 1B1 ; SIMVASTATIN-INDUCED MYOPATHY ; STATIN-INDUCED MYOPATHY ; REFLEX SENSITIVITY ; GENETIC-POLYMORPHISM ; INDUCED ANGIOEDEMA ; PHARMACOKINETICS ; ACE ; PRAVASTATIN ; HAPLOTYPES
英文摘要:

Clinical observations suggest that incidence of cough in Chinese taking angiotensin converting enzyme inhibitors is much higher than other racial groups. Cough is the most common adverse reaction of enalapril. We investigate whether SLCO1B1 genetic polymorphisms, previously reported to be important determinants of inter-individual variability in enalapril pharmacokinetics, are associated with the enalapril-induced cough. A cohort of 450 patients with essential hypertension taking 10 mg enalapril maleate were genotyped for the functional SLCO1B1 variants, 388A > G (Asn130Asp, rs2306283) and 521T > C (Val174Ala, rs4149056). The primary endpoint was cough, which was recorded when participants were bothered by cough and respiratory symptoms during enalapril treatment without an identifiable cause. SLCO1B1 521C allele conferred a 2-fold relative risk of enalapril-induced cough (95% confidence interval [CI] = 1.34-3.04, P = 6.2 x 10(-4)), and haplotype analysis suggested the relative risk of cough was 6.94-fold (95% CI = 1.30-37.07, P = 0.020) in SLCO1B1*15/*15 carriers. Furthermore, there was strong evidence for a gene-dose effect (percent with cough in those with 0, 1, or 2 copy of the 521C allele: 28.2%, 42.5%, and 71.4%, trend P = 6.6 x 10(-4)). Our study highlights, for the first time, SLCO1B1 variants are strongly associated with an increased risk of enalapril-induced cough. The findings will be useful to provide pharmacogenetic markers for enalapril treatment.

语种: 英语
所属项目编号: 2012AA02A517 ; 2012AA02A518 ; 81522048 ; 81573511 ; 81273595 ; 81302850 ; CX2014B100
项目资助者: National High Technology Research and Development Program of China, "863" Project ; National Scientific Foundation of China ; Hunan Provincial Innovation Foundation for Postgraduate
WOS记录号: WOS:000365383600001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66097
Appears in Collections:北京大学第二临床医学院_心血管内科_期刊论文

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作者单位: 1.Anhui Med Univ, Sch Hlth Adm, Hefei 230032, Peoples R China
2.Cent S Univ, Xiangya Hosp, Dept Clin Pharmacol, Changsha 410008, Hunan, Peoples R China
3.Cent S Univ, Inst Clin Pharmacol, Hunan Key Lab Pharmacogenet, Changsha 410078, Hunan, Peoples R China
4.Hunan Prov Cooperat Innovat Ctr Mol Target New Dr, Hengyang 421001, Peoples R China
5.Peking Univ, Peoples Hosp, Dept Cardiol, Beijing 100044, Peoples R China

Recommended Citation:
Luo, Jian-Quan,He, Fa-Zhong,Wang, Zhen-Min,et al. SLCO1B1 Variants and Angiotensin Converting Enzyme Inhibitor (Enalapril) -Induced Cough: a Pharmacogenetic Study[J]. SCIENTIFIC REPORTS,2015,5.
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