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学科主题: 药学
题名:
Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice)
作者: Zhang, Qingying; Ye, Min
关键词: Reviews ; Licorice ; Glycyrrhiza ; Triterpene saponins ; Flavonoids ; Chemical analysis ; Quality control
刊名: JOURNAL OF CHROMATOGRAPHY A
发表日期: 2009-03-13
DOI: 10.1016/j.chroma.2008.07.072
卷: 1216, 期:11, 页:1954-1969
收录类别: SCI
文章类型: Review
WOS标题词: Science & Technology
类目[WOS]: Biochemical Research Methods ; Chemistry, Analytical
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: PERFORMANCE LIQUID-CHROMATOGRAPHY ; GLYCYRRHIZA-URALENSIS FISCH ; CAPILLARY-ZONE-ELECTROPHORESIS ; LINKED-IMMUNOSORBENT-ASSAY ; COUNTER-CURRENT CHROMATOGRAPHY ; SUPERCRITICAL CO2 EXTRACTION ; NEAR-INFRARED SPECTROSCOPY ; ABDOMINAL FAT ACCUMULATION ; BETA-GLYCYRRHETINIC ACID ; DIABETIC KK-A(Y) MICE
英文摘要:

Gan-Cao, or licorice, is a popular Chinese herbal medicine derived from the dried roots and rhizomes of Glycyrrhiza uralensis, G. glabra, and G. inflata. The main bioactive constituents of licorice are triterpene saponins and various types of flavonoids. The contents of these compounds may vary in different licorice batches and thus affect the therapeutic effects. In order to ensure its efficacy and safety, sensitive and accurate methods for the qualitative and quantitative analyses of saponins and flavonoids are of significance for the comprehensive quality control of licorice. This review describes the progress in chemical analysis of licorice and its preparations since 2000. Newly established methods are summarized, including spectroscopy, thin-layer chromatography, gas chromatography, high-performance liquid chromatography (HPLC), liquid chromatography/mass spectrometry (LC/MS), capillary electrophoresis, high-speed counter-current chromatography (HSCCC), electrochemistry, and immunoassay. The sensitivity, selectivity and powerful separation capability of HPLC and CE allows the simultaneous detection Of Multiple compounds in licorice. LC/MS provides characteristic fragmentations for the rapid structural identification of licorice saponins and flavonoids. The combination of HPLC and LC/MS is currently the most powerful technique for the quality control of licorice. (C) 2008 Elsevier B.V. All rights reserved.

语种: 英语
WOS记录号: WOS:000264226500004
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66098
Appears in Collections:北京大学药学院_天然药物学系_期刊论文

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作者单位: Peking Univ, Hlth Sci Ctr, Dept Nat Med, Sch Pharmaceut Sci, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Qingying,Ye, Min. Chemical analysis of the Chinese herbal medicine Gan-Cao (licorice)[J]. JOURNAL OF CHROMATOGRAPHY A,2009,1216(11):1954-1969.
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