IR@PKUHSC  > 北京大学第一临床医学院  > 普通外科
学科主题临床医学
Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis
Yang, YM; Ramadani, M; Huang, YT
刊名WORLD JOURNAL OF GASTROENTEROLOGY
2003-12-01
9期:12页:2828-2831
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Gastroenterology & Hepatology
研究领域[WOS]Gastroenterology & Hepatology
关键词[WOS]INTERLEUKIN-1-BETA CONVERTING-ENZYME ; EPIDERMAL GROWTH-FACTOR ; CYCLIN D1 EXPRESSION ; ICE-LIKE PROTEASE ; DEATH GENE CED-3 ; CELL-DEATH ; FACTOR RECEPTOR ; POOR-PROGNOSIS ; FACTOR-ALPHA ; APOPTOSIS
英文摘要

AIM: To identify the expression of Caspase-1 (interleukin-1beta converting enzyme) and its role in adenoma of the pancreas and chronic pancreatitis.

METHODS: The expression of Caspase-1 was assessed in 42 pancreatic cancer tissue samples, 38 chronic pancreatitis specimens, and 9 normal pancreatic tissues by immunohistochemistry and Western blot analysis.

RESULTS: Overexpression of Caspase-1 was observed in both disorders, but there were differences in the expression patterns in distinct morphologic compartments. Pancreatic cancer tissues showed a clear cytoplasmatic overexpression of Caspase-1 in tumor cells of 71 % of the tumors, whereas normal pancreatic tissues showed only occasional immunoreactivity. In chronic pancreatitis, overexpression of Caspase-1 was found in atrophic acinar cells (89 %), hyperplastic ducts (87 %), and dedifferentiating acinar cells (84 %). Although in atrophic cells a clear nuclear expression was found, hyperplastic ducts and dedifferentiating acinar cells showed dear cytoplasmic expression. Western blot analysis revealed a marked expression of the 45 kDa precursor of Caspase-1 in pancreatic cancer and chronic pancreatitis (80 % and 86 %, respectively). Clear bands at 30 kDa, which suggested the p10-p20 heterodimer of active Caspase-1, were found in 60 % of the cancer tissue and 14 % of the pancreatitis tissue specimens, but not in normal pancreatic tissues.

CONCLUSION: Overexpression of Caspase-1 is a frequent event in pancreatic disorders and its differential expression patterns may reflect two functions of the protease. One is its participation in the apoptotic pathway in atrophic acinar cells and tumor-surrounding pancreatitis tissue, the other is its possible role in proliferative processes in pancreatic cancer cells and hyperplastic duct cells and dedifferentiating acinar cells in chronic pancreatitis.

语种英语
WOS记录号WOS:000187606800042
引用统计
被引频次:3[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66099
专题北京大学第一临床医学院_普通外科
作者单位1.Univ Ulm, Dept Gen Surg, D-89075 Ulm, Germany
2.Beijing Univ, Teaching Hosp 1, Dept Surg, Hlth Sci Ctr, Beijing 100034, Peoples R China
推荐引用方式
GB/T 7714
Yang, YM,Ramadani, M,Huang, YT. Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(12):2828-2831.
APA Yang, YM,Ramadani, M,&Huang, YT.(2003).Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis.WORLD JOURNAL OF GASTROENTEROLOGY,9(12),2828-2831.
MLA Yang, YM,et al."Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis".WORLD JOURNAL OF GASTROENTEROLOGY 9.12(2003):2828-2831.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Yang, YM]的文章
[Ramadani, M]的文章
[Huang, YT]的文章
百度学术
百度学术中相似的文章
[Yang, YM]的文章
[Ramadani, M]的文章
[Huang, YT]的文章
必应学术
必应学术中相似的文章
[Yang, YM]的文章
[Ramadani, M]的文章
[Huang, YT]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。