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学科主题: 临床医学
题名:
Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis
作者: Yang, YM; Ramadani, M; Huang, YT
刊名: WORLD JOURNAL OF GASTROENTEROLOGY
发表日期: 2003-12-01
卷: 9, 期:12, 页:2828-2831
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Gastroenterology & Hepatology
研究领域[WOS]: Gastroenterology & Hepatology
关键词[WOS]: INTERLEUKIN-1-BETA CONVERTING-ENZYME ; EPIDERMAL GROWTH-FACTOR ; CYCLIN D1 EXPRESSION ; ICE-LIKE PROTEASE ; DEATH GENE CED-3 ; CELL-DEATH ; FACTOR RECEPTOR ; POOR-PROGNOSIS ; FACTOR-ALPHA ; APOPTOSIS
英文摘要:

AIM: To identify the expression of Caspase-1 (interleukin-1beta converting enzyme) and its role in adenoma of the pancreas and chronic pancreatitis.

METHODS: The expression of Caspase-1 was assessed in 42 pancreatic cancer tissue samples, 38 chronic pancreatitis specimens, and 9 normal pancreatic tissues by immunohistochemistry and Western blot analysis.

RESULTS: Overexpression of Caspase-1 was observed in both disorders, but there were differences in the expression patterns in distinct morphologic compartments. Pancreatic cancer tissues showed a clear cytoplasmatic overexpression of Caspase-1 in tumor cells of 71 % of the tumors, whereas normal pancreatic tissues showed only occasional immunoreactivity. In chronic pancreatitis, overexpression of Caspase-1 was found in atrophic acinar cells (89 %), hyperplastic ducts (87 %), and dedifferentiating acinar cells (84 %). Although in atrophic cells a clear nuclear expression was found, hyperplastic ducts and dedifferentiating acinar cells showed dear cytoplasmic expression. Western blot analysis revealed a marked expression of the 45 kDa precursor of Caspase-1 in pancreatic cancer and chronic pancreatitis (80 % and 86 %, respectively). Clear bands at 30 kDa, which suggested the p10-p20 heterodimer of active Caspase-1, were found in 60 % of the cancer tissue and 14 % of the pancreatitis tissue specimens, but not in normal pancreatic tissues.

CONCLUSION: Overexpression of Caspase-1 is a frequent event in pancreatic disorders and its differential expression patterns may reflect two functions of the protease. One is its participation in the apoptotic pathway in atrophic acinar cells and tumor-surrounding pancreatitis tissue, the other is its possible role in proliferative processes in pancreatic cancer cells and hyperplastic duct cells and dedifferentiating acinar cells in chronic pancreatitis.

语种: 英语
WOS记录号: WOS:000187606800042
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66099
Appears in Collections:北京大学第一临床医学院_普通外科_期刊论文

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作者单位: 1.Univ Ulm, Dept Gen Surg, D-89075 Ulm, Germany
2.Beijing Univ, Teaching Hosp 1, Dept Surg, Hlth Sci Ctr, Beijing 100034, Peoples R China

Recommended Citation:
Yang, YM,Ramadani, M,Huang, YT. Overexpression of Caspase-1 in adenocarcinoma of pancreas and chronic pancreatitis[J]. WORLD JOURNAL OF GASTROENTEROLOGY,2003,9(12):2828-2831.
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