IR@PKUHSC  > 北京大学精神卫生研究所
学科主题精神卫生
Apolipoprotein E epsilon 4 Modulates Functional Brain Connectome in Alzheimer′s Disease
Wang, Jinhui1,2,3,4; Wang, Xiao5,6; He, Yi5,6; Yu, Xin5,6; Wang, Huali5,6; He, Yong1,2,7
关键词connectomics graph theory functional connectivity module default mode resting-state fMRI
刊名HUMAN BRAIN MAPPING
2015-05-01
DOI10.1002/hbm.22740
36期:5页:1828-1846
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]SMALL-WORLD NETWORKS ; RESTING-STATE ; APOE GENOTYPE ; GENETIC RISK ; CORTICAL NETWORKS ; CONNECTIVITY MRI ; DEFAULT NETWORK ; WORKING-MEMORY ; AMYLOID BURDEN ; OLDER PERSONS
英文摘要

The apolipoprotein E (APOE) 4 allele is a well-established genetic risk factor for Alzheimer′s disease (AD). Recent research has demonstrated an APOE 4-mediated modulation of intrinsic functional brain networks in cognitively normal individuals. However, it remains largely unknown whether and how APOE 4 affects the brain′s functional network architecture in patients with AD. Using resting-state functional MRI and graph-theory approaches, we systematically investigated the topological organization of whole-brain functional networks in 16 APOE 4 carriers and 26 matched noncarriers with AD at three levels: global whole-brain, intermediate module, and regional node/connection. Neuropsychological analysis showed that the APOE 4 carriers performed worse on delayed memory but better on a late item generation of a verbal fluency task (associated with executive function) than noncarriers. Whole-brain graph analyses revealed that APOE 4 significantly disrupted whole-brain topological organization as characterized by (i) reduced parallel information transformation efficiency; (ii) decreased intramodular connectivity within the posterior default mode network (pDMN) and intermodular connectivity of the pDMN and executive control network (ECN) with other neuroanatomical systems; and (iii) impaired functional hubs and their rich-club connectivities that primarily involve the pDMN, ECN, and sensorimotor systems. Further simulation analysis indicated that these altered connectivity profiles of the pDMN and ECN largely accounted for the abnormal global network topology. Finally, the changes in network topology exhibited significant correlations with the patients′ cognitive performances. Together, our findings suggest that the APOE genotype modulates large-scale brain networks in AD and shed new light on the gene-connectome interaction in this disease. Hum Brain Mapp 36:1828-1846, 2015. (c) 2015 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000353068300015
项目编号2014CB846102 ; 81225012 ; 81030028 ; 81171018 ; 31221003 ; LZ13C090001 ; 2012D009012000003 ; Z111107067311036 ; PD11001005002013
资助机构National Key Basic Research Program of China (973 project) ; National Science Fund for Distinguished Young Scholars ; Natural Science Foundation of China ; Zhejiang Provincial Natural Science Foundation of China ; Beijing Funding for Training Talents ; Beijing Natural Science Foundation ; State Key Laboratory of Cognitive Neuroscience and Learning ; Beijing Normal University, China ; Zhejiang Key Laboratory for Research in Assessment of Cognitive Impairments
引用统计
被引频次:23[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66102
专题北京大学精神卫生研究所
北京大学口腔医学院_儿童口腔科
北京大学精神卫生研究所_精神科
作者单位1.Beijing Normal Univ, State Key Lab Cognit Neurosci & Learning, Beijing 100875, Peoples R China
2.Beijing Normal Univ, IDG McGovern Inst Brain Res, Beijing 100875, Peoples R China
3.Hangzhou Normal Univ, Ctr Cognit & Brain Disorders, Hangzhou, Zhejiang, Peoples R China
4.Zhejiang Key Lab Res Assessment Cognit Impairment, Hangzhou, Zhejiang, Peoples R China
5.Peking Univ, Inst Mental Hlth, Dementia Care & Res Ctr, Beijing 100871, Peoples R China
6.Peking Univ, Key Lab Mental Hlth, Minist Hlth, Beijing 100871, Peoples R China
7.Beijing Normal Univ, Ctr Collaborat & Innovat Brain & Learning Sci, Beijing 100875, Peoples R China
推荐引用方式
GB/T 7714
Wang, Jinhui,Wang, Xiao,He, Yi,et al. Apolipoprotein E epsilon 4 Modulates Functional Brain Connectome in Alzheimer′s Disease[J]. HUMAN BRAIN MAPPING,2015,36(5):1828-1846.
APA Wang, Jinhui,Wang, Xiao,He, Yi,Yu, Xin,Wang, Huali,&He, Yong.(2015).Apolipoprotein E epsilon 4 Modulates Functional Brain Connectome in Alzheimer′s Disease.HUMAN BRAIN MAPPING,36(5),1828-1846.
MLA Wang, Jinhui,et al."Apolipoprotein E epsilon 4 Modulates Functional Brain Connectome in Alzheimer′s Disease".HUMAN BRAIN MAPPING 36.5(2015):1828-1846.
条目包含的文件
条目无相关文件。
个性服务
推荐该条目
保存到收藏夹
查看访问统计
导出为Endnote文件
谷歌学术
谷歌学术中相似的文章
[Wang, Jinhui]的文章
[Wang, Xiao]的文章
[He, Yi]的文章
百度学术
百度学术中相似的文章
[Wang, Jinhui]的文章
[Wang, Xiao]的文章
[He, Yi]的文章
必应学术
必应学术中相似的文章
[Wang, Jinhui]的文章
[Wang, Xiao]的文章
[He, Yi]的文章
相关权益政策
暂无数据
收藏/分享
所有评论 (0)
暂无评论
 

除非特别说明,本系统中所有内容都受版权保护,并保留所有权利。