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学科主题: 药学
题名:
Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues
作者: Chen, Bifeng1; Li, Wei2; Lv, Cong1; Zhao, Manman2; Jin, Hongwei1; Jin, Hongfang2; Du, Junbao2; Zhang, Liangren1; Tang, Xinjing1
刊名: ANALYST
发表日期: 2013
DOI: 10.1039/c2an36113b
卷: 138, 期:3, 页:946-951
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Analytical
研究领域[WOS]: Chemistry
关键词[WOS]: H2S ; RAT ; ANGIOGENESIS ; PERFUSION ; BLOOD ; MICE
英文摘要:

A coumarin-based fluorescence chemoprobe was developed and evaluated for the selective and sensitive detection of hydrogen sulfide in degassed PBS buffers and fetal bovine serum. Fluorescence detection of hydrogen sulfide in living cells was also successfully achieved using two-photon confocal fluorescence imaging. Further in situ visualization of endogenous H2S was realized in cardiac tissues of normal rats and atherosclerosis (AS) rats.

语种: 英语
所属项目编号: 2013CB933800 ; 21072015 ; NCET10-0203
项目资助者: National Basic Research Program of China (&prime ; 973&prime ; Program) ; National Natural Science Foundation of China ; Program for New Century Excellent Talents in University
WOS记录号: WOS:000312944400032
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66104
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, State Key Lab Nat & Biomimet Drugs, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, Dept Pediat, Hosp 1, Beijing 100034, Peoples R China

Recommended Citation:
Chen, Bifeng,Li, Wei,Lv, Cong,et al. Fluorescent probe for highly selective and sensitive detection of hydrogen sulfide in living cells and cardiac tissues[J]. ANALYST,2013,138(3):946-951.
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