IR@PKUHSC  > 北京大学第一临床医学院  > 放射治疗科
学科主题临床医学
The Effect of Age and Cerebral Ischemia on Diffusion-Weighted Proton MR Spectroscopy of the Human Brain
Zheng, D. D.1; Liu, Z. H.2; Fang, J.1,3; Wang, X. Y.1,2; Zhang, J.1,3
刊名AMERICAN JOURNAL OF NEURORADIOLOGY
2012-03-01
DOI10.3174/ajnr.A2793
33期:3页:563-568
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
资助者Fundamental Research Funds for the Central Universities of China ; Fundamental Research Funds for the Central Universities of China
研究领域[WOS]Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]MAGNETIC-RESONANCE-SPECTROSCOPY ; RAT-BRAIN ; IN-VIVO ; CORTICAL CIRCUITS ; ARTERY OCCLUSION ; NMR-SPECTROSCOPY ; COEFFICIENT ; METABOLITES ; APOPTOSIS ; WATER
英文摘要

BACKGROUND AND PURPOSE: DW-MRS is a promising tool for the noninvasive identification of the cellular response to cerebral ischemia. To date, the potential confounding effects of aging and the stage of ischemia are unknown. We, therefore, examined the cross-sectional effects of age and different stages of cerebral ischemia on the diffusion of brain metabolites.

MATERIALS AND METHODS: The ADCs of 3 major metabolites, including Cho, Cr, and NAA were measured by DW-MRS in healthy younger (n = 26, 24 +/- 2.2 years of age) and older (n = 17, 63 +/- 7.0 years of age) adults, as well as in patients with acute (n = 7, 57 +/- 4.0 years of age) and subacute (n = 12, 62 +/- 7.8 years of age) cerebral ischemia.

RESULTS: Compared with younger adults, healthy older adults presented with significantly reduced ADC values of NAA (P = .000052), Cr (P = .000018), and Cho (P = .00075). Meanwhile, the ADC values of NAA (F-2,F-36 = 6.057, P = .006), Cr (F-2,F-36 = 5.634, P = .008), and Cho (F-2,F-36 = 8.167, P = .001) were significantly different among the acute cerebral ischemia group, subacute cerebral ischemia group, and healthy older controls. These metabolites decreased in the acute stage of cerebral ischemia but increased in the subacute stage, compared with age-matched controls.

CONCLUSIONS: The effect of age should be considered when analyzing diffusion of cerebral metabolites with DW-MRS. Our observations also suggest that metabolite diffusion data may be used to reveal changes in the intracellular environment, depending on the pathologic status of ischemia.

语种英语
所属项目编号2009-11-006
资助者Fundamental Research Funds for the Central Universities of China ; Fundamental Research Funds for the Central Universities of China
WOS记录号WOS:000301870300033
Citation statistics
Cited Times:13[WOS]   [WOS Record]     [Related Records in WOS]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66107
Collection北京大学第一临床医学院_放射治疗科
作者单位1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China
Recommended Citation
GB/T 7714
Zheng, D. D.,Liu, Z. H.,Fang, J.,et al. The Effect of Age and Cerebral Ischemia on Diffusion-Weighted Proton MR Spectroscopy of the Human Brain[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2012,33(3):563-568.
APA Zheng, D. D.,Liu, Z. H.,Fang, J.,Wang, X. Y.,&Zhang, J..(2012).The Effect of Age and Cerebral Ischemia on Diffusion-Weighted Proton MR Spectroscopy of the Human Brain.AMERICAN JOURNAL OF NEURORADIOLOGY,33(3),563-568.
MLA Zheng, D. D.,et al."The Effect of Age and Cerebral Ischemia on Diffusion-Weighted Proton MR Spectroscopy of the Human Brain".AMERICAN JOURNAL OF NEURORADIOLOGY 33.3(2012):563-568.
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