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学科主题: 临床医学
题名:
The Effect of Age and Cerebral Ischemia on Diffusion-Weighted Proton MR Spectroscopy of the Human Brain
作者: Zheng, D. D.1; Liu, Z. H.2; Fang, J.1,3; Wang, X. Y.1,2; Zhang, J.1,3
刊名: AMERICAN JOURNAL OF NEURORADIOLOGY
发表日期: 2012-03-01
DOI: 10.3174/ajnr.A2793
卷: 33, 期:3, 页:563-568
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Neuroimaging ; Radiology, Nuclear Medicine & Medical Imaging
研究领域[WOS]: Neurosciences & Neurology ; Radiology, Nuclear Medicine & Medical Imaging
关键词[WOS]: MAGNETIC-RESONANCE-SPECTROSCOPY ; RAT-BRAIN ; IN-VIVO ; CORTICAL CIRCUITS ; ARTERY OCCLUSION ; NMR-SPECTROSCOPY ; COEFFICIENT ; METABOLITES ; APOPTOSIS ; WATER
英文摘要:

BACKGROUND AND PURPOSE: DW-MRS is a promising tool for the noninvasive identification of the cellular response to cerebral ischemia. To date, the potential confounding effects of aging and the stage of ischemia are unknown. We, therefore, examined the cross-sectional effects of age and different stages of cerebral ischemia on the diffusion of brain metabolites.

MATERIALS AND METHODS: The ADCs of 3 major metabolites, including Cho, Cr, and NAA were measured by DW-MRS in healthy younger (n = 26, 24 +/- 2.2 years of age) and older (n = 17, 63 +/- 7.0 years of age) adults, as well as in patients with acute (n = 7, 57 +/- 4.0 years of age) and subacute (n = 12, 62 +/- 7.8 years of age) cerebral ischemia.

RESULTS: Compared with younger adults, healthy older adults presented with significantly reduced ADC values of NAA (P = .000052), Cr (P = .000018), and Cho (P = .00075). Meanwhile, the ADC values of NAA (F-2,F-36 = 6.057, P = .006), Cr (F-2,F-36 = 5.634, P = .008), and Cho (F-2,F-36 = 8.167, P = .001) were significantly different among the acute cerebral ischemia group, subacute cerebral ischemia group, and healthy older controls. These metabolites decreased in the acute stage of cerebral ischemia but increased in the subacute stage, compared with age-matched controls.

CONCLUSIONS: The effect of age should be considered when analyzing diffusion of cerebral metabolites with DW-MRS. Our observations also suggest that metabolite diffusion data may be used to reveal changes in the intracellular environment, depending on the pathologic status of ischemia.

语种: 英语
所属项目编号: 2009-11-006
项目资助者: Fundamental Research Funds for the Central Universities of China
WOS记录号: WOS:000301870300033
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66107
Appears in Collections:北京大学第一临床医学院_放射治疗科_期刊论文

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作者单位: 1.Peking Univ, Coll Engn, Beijing 100871, Peoples R China
2.Peking Univ, Acad Adv Interdisciplinary Studies, Beijing 100871, Peoples R China
3.Peking Univ, Hosp 1, Dept Radiol, Beijing 100871, Peoples R China

Recommended Citation:
Zheng, D. D.,Liu, Z. H.,Fang, J.,et al. The Effect of Age and Cerebral Ischemia on Diffusion-Weighted Proton MR Spectroscopy of the Human Brain[J]. AMERICAN JOURNAL OF NEURORADIOLOGY,2012,33(3):563-568.
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