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学科主题: 临床医学
题名:
Mode of myosin transportation in living cells studied by single particle tracking
作者: Liang, Zhang-Yi; Xu, Ning; Guan, Ying-Hua; Zhang, You-Yi; Zhao, Xin-Sheng
关键词: single particle tracking ; live cell ; alpha(1A)-adrenergic receptor ; myosin assay
刊名: CHINESE JOURNAL OF CHEMICAL PHYSICS
发表日期: 2007-08-27
DOI: 10.1088/1.674-0068/20/04/445-448
卷: 20, 期:4, 页:445-448
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Physics, Atomic, Molecular & Chemical
研究领域[WOS]: Physics
关键词[WOS]: HAND-OVER-HAND ; ALPHA(1)-ADRENOCEPTOR SUBTYPES ; KINETIC MECHANISM ; STEP-SIZE ; MOTOR ; ALPHA(1B)-ADRENOCEPTOR ; INTERNALIZATION ; LOCALIZATION ; KINESIN ; ACTIN
英文摘要:

The transport of internalized alpha(1A)-adrenergic receptor (alpha(1A)-AR) by myosin protein in live cells was studied. The technique of single particle tracking by fluorescence imaging with high temporal and spatial resolution was used. The endosomes of alpha(1A)-AR were transported along actin filaments in a step-by-step mode. The average step-size in different time resolutions is consistent with the step-size of myosin assay in vitro. With the simulation of the stepwise traces in different time resolutions, we found that the kinetic process of each step is in coherence with the single myosin assay in vitro.

语种: 英语
WOS记录号: WOS:000249465100019
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66108
Appears in Collections:北京大学第三临床医学院_心血管内科_期刊论文

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作者单位: 1.Minist Educ, Key Lab Mol Cardiovasc Sci, Beijing 100083, Peoples R China
2.Peking Univ Third Hosp, Inst Vasc Med, Beijing 100083, Peoples R China
3.Peking Univ, Coll Chem & Mol Engn, Beijing Natl Lab Mol Sci, State Key Lab Struct Chem Unstable & Stable Speci, Beijing 100871, Peoples R China
4.Peking Univ, Coll Chem & Mol Engn, Dept Biol Chem, Beijing 100871, Peoples R China

Recommended Citation:
Liang, Zhang-Yi,Xu, Ning,Guan, Ying-Hua,et al. Mode of myosin transportation in living cells studied by single particle tracking[J]. CHINESE JOURNAL OF CHEMICAL PHYSICS,2007,20(4):445-448.
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