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Influence of tramadol on morphine discriminative behavior in rats
Ren, YH; Zheng, JW
关键词tramadol dependency (psychology) discrimination (psychology) reinforcement (psychology)
刊名ACTA PHARMACOLOGICA SINICA
2000-10-01
21期:10页:924-926
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Multidisciplinary ; Pharmacology & Pharmacy
研究领域[WOS]Chemistry ; Pharmacology & Pharmacy
英文摘要

AIM: To study the potential of the psychological dependence of tramadol. METHODS: Rats were trained to discriminate 4.0 mg/kg morphine, and to discriminate 0.5 mg/kg methamphetamine (MA) from saline under a fixed-ratio (FR10) schedule of reinforcement. After they acquired the discrimination, different doses of tramadol were used to substitute for training dose of morphine and MA. Naltrexone was injected concomitantly with tramadol. RESULTS: Tramadol fully substituted morphine at a dose of 32 mg/kg or higher. The ED50 value of the discriminative effects of tramadol was 20.94 mg/kg, higher than that of morphine (2.04! mg/kg, P < 0.01). MA failed to generalize to tramadol at the doses tested. Naltrexone antagnized the discriminative respondse of tramadol. CONCLUSION: Tramadol can substitute for morphine in morphine discriminative rats. The discriminative stimulus effects of tramadol are mediated by a mu opioid mechanism.

语种英语
WOS记录号WOS:000089725800011
引用统计
被引频次:13[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66110
专题中国药物依赖性研究所
作者单位Beijing Med Univ, Natl Inst Drug Dependence, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Ren, YH,Zheng, JW. Influence of tramadol on morphine discriminative behavior in rats[J]. ACTA PHARMACOLOGICA SINICA,2000,21(10):924-926.
APA Ren, YH,&Zheng, JW.(2000).Influence of tramadol on morphine discriminative behavior in rats.ACTA PHARMACOLOGICA SINICA,21(10),924-926.
MLA Ren, YH,et al."Influence of tramadol on morphine discriminative behavior in rats".ACTA PHARMACOLOGICA SINICA 21.10(2000):924-926.
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