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学科主题基础医学
New paradigms in inflammatory signaling in vascular endothelial cells
Xiao, Lei1; Liu, Yahan2; Wang, Nanping1,2
关键词inflammation endothelium signaling inflammasome microRNA
刊名AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY
2014-02-01
DOI10.1152/ajpheart.00182.2013
306期:3页:H317-H325
收录类别SCI
文章类型Review
WOS标题词Science & Technology
类目[WOS]Cardiac & Cardiovascular Systems ; Physiology ; Peripheral Vascular Disease
研究领域[WOS]Cardiovascular System & Cardiology ; Physiology
关键词[WOS]NF-KAPPA-B ; TOLL-LIKE RECEPTORS ; LOW-DENSITY-LIPOPROTEIN ; CORONARY-ARTERY-DISEASE ; INNATE IMMUNE-RESPONSE ; ADHESION MOLECULE-1 ; TNF-ALPHA ; LEUKOCYTE RECRUITMENT ; GENE-EXPRESSION ; IKK-GAMMA
英文摘要

Inflammation is a basic cellular process in innate and adaptive immunity. Vascular endothelial cells play an important role in the initiation, amplification, and resolution of the inflammatory response. Deregulated inflammatory response is implicated in a variety of cardiovascular diseases such as atherosclerosis, obesity, diabetes, and hypertension. Recent studies have made significant progresses in the understanding of the complex molecular pathways that mediate the pro-and anti-inflammatory signaling in endothelial cells (ECs). Specifically, a number of macromolecular complexes termed as signalosomes have been identified to integrate the proinflammatory signaling from the membrane receptors to key transcription factors such as nuclear factor-kappa B (NF-kappa B). Inflammasomes are associated with the pattern-recognition receptors such as Toll-like receptors (TLRs), nucleotide-binding oligomerization- domain (NOD)-like receptors (NLRs) to mediate innate immunity responses. Emerging evidence has also revealed that noncoding microRNAs constitute a new class of intra-and intercellular signaling molecules to modulate inflammation in ECs. Thus this article will briefly summarize these new mechanisms with a special emphasis in the context of cardiovascular diseases.

语种英语
WOS记录号WOS:000331448300003
项目编号81220108005 ; 81300242 ; 81300189
资助机构National Natural Science Foundation Grants
引用统计
被引频次:53[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66125
专题北京大学基础医学院_心血管所
北京大学基础医学院
作者单位1.Xi An Jiao Tong Univ, Cardiovasc Res Ctr, Sch Med, Xian 710049, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Inst Cardiovasc Sci, Beijing 100871, Peoples R China
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Xiao, Lei,Liu, Yahan,Wang, Nanping. New paradigms in inflammatory signaling in vascular endothelial cells[J]. AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,2014,306(3):H317-H325.
APA Xiao, Lei,Liu, Yahan,&Wang, Nanping.(2014).New paradigms in inflammatory signaling in vascular endothelial cells.AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY,306(3),H317-H325.
MLA Xiao, Lei,et al."New paradigms in inflammatory signaling in vascular endothelial cells".AMERICAN JOURNAL OF PHYSIOLOGY-HEART AND CIRCULATORY PHYSIOLOGY 306.3(2014):H317-H325.
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