IR@PKUHSC  > 北京大学基础医学院  > 免疫学系
学科主题基础医学
Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1
Fu, WX; Zhang, Y; Zhang, J; Chen, WF
关键词chemokine chemokine receptor inflammation mouse CXCR1 neutrophils
刊名CYTOKINE
2005-07-07
DOI10.1016/j.cyto.2005.02.005
31期:1页:9-17
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Immunology
研究领域[WOS]Biochemistry & Molecular Biology ; Cell Biology ; Immunology
关键词[WOS]HUMAN INTERLEUKIN-8 RECEPTOR ; MACROPHAGE INFLAMMATORY PROTEIN-2 ; IL-8 RECEPTOR ; CHEMOATTRACTANT RECEPTORS ; GRO-ALPHA ; NEUTROPHIL ; EXPRESSION ; IDENTIFICATION ; LEUKOCYTES ; ENDOTOXIN
英文摘要

CXCR2/IL-8RB was the only receptor previously reported in mice for ELR+ CXC chemokines, whereas the receptors for these chemokines in human include both CXCR1 and CXCR2. In this study, we cloned the full length cDNA of the mouse CXCR1 (mCXCR1) gene. The deduced amino acid of mCXCR1 was 77% and 58% identical to the rat and human CXCR1, respectively. RT-PCR and Northern blot analysis showed that mCXCR1 mRNA was expressed in lung, spleen, thymus, peripheral blood leukocytes, as well as in the isolated neutrophils. In a mouse respiratory inflammation model induced by lipopolysaccharide, a large number of neutrophils infiltrated into the lung and, meanwhile, the mCXCR1 expression was significantly increased in the recruited neutrophils, suggesting that mCXCR1 may mediate the recruitment of neutrophils to the inflammation site under certain infections. (c) 2005 Elsevier Ltd. All rights reserved.

语种英语
WOS记录号WOS:000230444000002
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被引频次:43[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66126
专题北京大学基础医学院_免疫学系
作者单位Peking Univ, Ctr Hlth, Dept Immunol, Beijing 100083, Peoples R China
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GB/T 7714
Fu, WX,Zhang, Y,Zhang, J,et al. Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1[J]. CYTOKINE,2005,31(1):9-17.
APA Fu, WX,Zhang, Y,Zhang, J,&Chen, WF.(2005).Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1.CYTOKINE,31(1),9-17.
MLA Fu, WX,et al."Cloning and characterization of mouse homolog of the CXC chemokine receptor CXCR1".CYTOKINE 31.1(2005):9-17.
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