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学科主题: 精神卫生
题名:
Psychiatrists′ awareness of partial and nonadherence to antipsychotic medication in schizophrenia: results from an Asia-Pacific survey
作者: Manuel Olivares, Jose1; Thirunavukarasu, Manickam2; Kulkarni, Jayashri3,4; Zhang, Hong Yan5; Zhang, Mingyuan6; Zhang, Fan7
关键词: schizophrenia ; antipsychotic ; APAC ; survey ; adherence
刊名: NEUROPSYCHIATRIC DISEASE AND TREATMENT
发表日期: 2013
DOI: 10.2147/NDT.S49080
卷: 9, 页:1163-1170
收录类别: SCI ; SSCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Clinical Neurology ; Psychiatry
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry
关键词[WOS]: TREATMENT ADHERENCE ; RELAPSE ; RISPERIDONE ; OLANZAPINE ; QUETIAPINE ; OUTCOMES ; EPISODE ; EAST
英文摘要:

Background: Nonadherence is a well-known problem among schizophrenia patients, among whom relapse is fivefold more likely, adversely affecting health, employment, and social functioning. The Spanish Adherencia Terapeutica en la Esquizofrenia (ADHES) survey was developed to determine the scope and causes of medication nonadherence in schizophrenia.

Methods: The 20-question ADHES survey was distributed to 19,370 psychiatrists in 13 Asia-Pacific countries in January-April 2012, to ascertain psychiatrists′ perceptions of antipsychotic medication adherence levels among their schizophrenia patients, reasons for partial/-nonadherence, their preferred methods of assessing adherence, and strategies to improve adherence. Responses are reported as mean and range across countries.

Results: Four thousand, six hundred sixty one psychiatrists (24% of recipients) completed the survey (highest contributors: People′s Republic of China, 1854; India, 1616). Psychiatrists perceived that 56% (range, 30%-71%) of schizophrenia patients were non-or partially adherent to medication. Patients discontinue medication primarily due to lack of insight into their condition (mean, 37%; 1%-65%) and because patients consider medication unnecessary when feeling better (mean, 27%; 15%-68%). Over half of psychiatrists (mean, 55%; 42%-99%) assess medication adherence at every visit, almost exclusively (81%) by asking their patients, versus quantitative measures. One in three psychiatrists expressed their preference to switch to or add a long-acting antipsychotic to improve adherence (15%-82%).

Conclusions: The substantial prevalence of partial/nonadherence to medication demonstrates that more proactive management of patients with schizophrenia is needed to improve adherence and thereby treatment outcomes.

Registration: Registration of this study was not required.

语种: 英语
项目资助者: Janssen Asia Pacific, a division of Johnson and Johnson Pte. Ltd, Singapore
WOS记录号: WOS:000322875400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66146
Appears in Collections:北京大学精神卫生研究所_期刊论文

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作者单位: 1.SRM Med Coll Hosp & Res Ctr, Dept Psychiat, Madras, Tamil Nadu, India
2.Complejo Hosp Univ Vigo, Dept Psychiat, Hosp Meixoeiro, Vigo 36214, Pontevedra, Spain
3.Peking Univ, Inst Mental Hlth, Dept Psychiat, Beijing 100871, Peoples R China
4.Monash Univ, Dept Psychiat, Prahran, Vic, Australia
5.Alfred Hosp, Prahran, Vic 3181, Australia
6.Shanghai Mental Hlth Ctr, Dept Psychiat, Shanghai, Peoples R China
7.Xian Janssen Pharmaceut, Med Affairs, Beijing, Peoples R China

Recommended Citation:
Manuel Olivares, Jose,Thirunavukarasu, Manickam,Kulkarni, Jayashri,et al. Psychiatrists′ awareness of partial and nonadherence to antipsychotic medication in schizophrenia: results from an Asia-Pacific survey[J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT,2013,9:1163-1170.
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