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Psychiatrists′ awareness of partial and nonadherence to antipsychotic medication in schizophrenia: results from an Asia-Pacific survey
Manuel Olivares, Jose1; Thirunavukarasu, Manickam2; Kulkarni, Jayashri3,4; Zhang, Hong Yan5; Zhang, Mingyuan6; Zhang, Fan7
关键词schizophrenia antipsychotic APAC survey adherence
刊名NEUROPSYCHIATRIC DISEASE AND TREATMENT
2013
DOI10.2147/NDT.S49080
9页:1163-1170
收录类别SCI ; SSCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Clinical Neurology ; Psychiatry
研究领域[WOS]Neurosciences & Neurology ; Psychiatry
关键词[WOS]TREATMENT ADHERENCE ; RELAPSE ; RISPERIDONE ; OLANZAPINE ; QUETIAPINE ; OUTCOMES ; EPISODE ; EAST
英文摘要

Background: Nonadherence is a well-known problem among schizophrenia patients, among whom relapse is fivefold more likely, adversely affecting health, employment, and social functioning. The Spanish Adherencia Terapeutica en la Esquizofrenia (ADHES) survey was developed to determine the scope and causes of medication nonadherence in schizophrenia.

Methods: The 20-question ADHES survey was distributed to 19,370 psychiatrists in 13 Asia-Pacific countries in January-April 2012, to ascertain psychiatrists′ perceptions of antipsychotic medication adherence levels among their schizophrenia patients, reasons for partial/-nonadherence, their preferred methods of assessing adherence, and strategies to improve adherence. Responses are reported as mean and range across countries.

Results: Four thousand, six hundred sixty one psychiatrists (24% of recipients) completed the survey (highest contributors: People′s Republic of China, 1854; India, 1616). Psychiatrists perceived that 56% (range, 30%-71%) of schizophrenia patients were non-or partially adherent to medication. Patients discontinue medication primarily due to lack of insight into their condition (mean, 37%; 1%-65%) and because patients consider medication unnecessary when feeling better (mean, 27%; 15%-68%). Over half of psychiatrists (mean, 55%; 42%-99%) assess medication adherence at every visit, almost exclusively (81%) by asking their patients, versus quantitative measures. One in three psychiatrists expressed their preference to switch to or add a long-acting antipsychotic to improve adherence (15%-82%).

Conclusions: The substantial prevalence of partial/nonadherence to medication demonstrates that more proactive management of patients with schizophrenia is needed to improve adherence and thereby treatment outcomes.

Registration: Registration of this study was not required.

语种英语
WOS记录号WOS:000322875400001
引用统计
被引频次:8[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66146
专题北京大学精神卫生研究所
作者单位1.SRM Med Coll Hosp & Res Ctr, Dept Psychiat, Madras, Tamil Nadu, India
2.Complejo Hosp Univ Vigo, Dept Psychiat, Hosp Meixoeiro, Vigo 36214, Pontevedra, Spain
3.Peking Univ, Inst Mental Hlth, Dept Psychiat, Beijing 100871, Peoples R China
4.Monash Univ, Dept Psychiat, Prahran, Vic, Australia
5.Alfred Hosp, Prahran, Vic 3181, Australia
6.Shanghai Mental Hlth Ctr, Dept Psychiat, Shanghai, Peoples R China
7.Xian Janssen Pharmaceut, Med Affairs, Beijing, Peoples R China
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GB/T 7714
Manuel Olivares, Jose,Thirunavukarasu, Manickam,Kulkarni, Jayashri,et al. Psychiatrists′ awareness of partial and nonadherence to antipsychotic medication in schizophrenia: results from an Asia-Pacific survey[J]. NEUROPSYCHIATRIC DISEASE AND TREATMENT,2013,9:1163-1170.
APA Manuel Olivares, Jose,Thirunavukarasu, Manickam,Kulkarni, Jayashri,Zhang, Hong Yan,Zhang, Mingyuan,&Zhang, Fan.(2013).Psychiatrists′ awareness of partial and nonadherence to antipsychotic medication in schizophrenia: results from an Asia-Pacific survey.NEUROPSYCHIATRIC DISEASE AND TREATMENT,9,1163-1170.
MLA Manuel Olivares, Jose,et al."Psychiatrists′ awareness of partial and nonadherence to antipsychotic medication in schizophrenia: results from an Asia-Pacific survey".NEUROPSYCHIATRIC DISEASE AND TREATMENT 9(2013):1163-1170.
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