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Comparison of two species of Notopterygium by high-performance Liquid chromatography-photodiode array detection-electrospray ionization tandem mass spectrometry
Liu, Guo-Qang1; Dong, Jing2; Wang, Hong1; Hashi, Yuki2; Chen, Shi-Zhong1
关键词Qianghuo coumarins phenolic compounds electrospray ionization high-performance liquid chromatography mass spectrometry
刊名EUROPEAN JOURNAL OF MASS SPECTROMETRY
2012
DOI10.1255/ejms.1169
18期:1页:59-69
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Physics, Atomic, Molecular & Chemical ; Spectroscopy
研究领域[WOS]Physics ; Spectroscopy
关键词[WOS]FINGERPRINT ANALYSIS ; ANGELICA-DAHURICA ; FUROCOUMARINS ; CONSTITUENTS ; IDENTIFICATION ; FORBESII ; EXTRACT ; HPLC ; MSN
英文摘要

Notopterygium incisum Ting ex H.T. Chang (N. incisum) and Notopterygium forbesii Boiss (N. forbesii) are two medicinal species of Qianghuo (a well-known traditional herbal medicine in China) that are widely used in clinical prescriptions for the treatment of colds and rheumatism. To compare the chemical constituents of these two plant materials, the phenolic constituents and coumarins of these two species were comprehensively and systematically analyzed by high-performance liquid chromatography-photodiode array detection-electrospray ionization tandem mass spectrometry (HPLC/DAD/ESI-MSn) for the first time. A total of 25 compounds (nine phenolic compounds and 16 coumarins) were detected in the methanol extracts. These compounds were separated on a C18 column and identified or tentatively characterized on the basis of their UV spectra and MS fragmentation behavior. In contrast to previous reports, we found that these two plant species possess very different coumarin patterns. 0-Demethylfuropinnarin (18), phenethytferulate (19), notopterol (20), and isoimperatorin (22) were the predominant constituents of N. incisum, whereas nodakenin (6), 6-0-trans-feruloylnodakenin (12), p-hydroxypenethylanisate (16) and isoimperatorin (22) were the major constituents of N. forbesii. 0-Demethylfuropinnarin (18), phenethylferulate (19) and notopterol (20) were only detected in N. incisum and can be regarded as useful taxonomic markers for differentiating these two plant species. Considering the marked differences in the main chemical constituents of N. incisum and N. forbesii, the biological activities of these two species should be further investigated and compared to ensure consistency and efficacy in the pharmaceutical applications of these materials.

语种英语
WOS记录号WOS:000303263400005
引用统计
被引频次:1[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66147
专题北京大学药学院
作者单位1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Shimadzu Int Trading Shanghai Co Ltd, Beijing Off, Beijing 100020, Peoples R China
推荐引用方式
GB/T 7714
Liu, Guo-Qang,Dong, Jing,Wang, Hong,et al. Comparison of two species of Notopterygium by high-performance Liquid chromatography-photodiode array detection-electrospray ionization tandem mass spectrometry[J]. EUROPEAN JOURNAL OF MASS SPECTROMETRY,2012,18(1):59-69.
APA Liu, Guo-Qang,Dong, Jing,Wang, Hong,Hashi, Yuki,&Chen, Shi-Zhong.(2012).Comparison of two species of Notopterygium by high-performance Liquid chromatography-photodiode array detection-electrospray ionization tandem mass spectrometry.EUROPEAN JOURNAL OF MASS SPECTROMETRY,18(1),59-69.
MLA Liu, Guo-Qang,et al."Comparison of two species of Notopterygium by high-performance Liquid chromatography-photodiode array detection-electrospray ionization tandem mass spectrometry".EUROPEAN JOURNAL OF MASS SPECTROMETRY 18.1(2012):59-69.
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