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学科主题: 药学
题名:
Comparison of two species of Notopterygium by high-performance Liquid chromatography-photodiode array detection-electrospray ionization tandem mass spectrometry
作者: Liu, Guo-Qang1; Dong, Jing2; Wang, Hong1; Hashi, Yuki2; Chen, Shi-Zhong1
关键词: Qianghuo ; coumarins ; phenolic compounds ; electrospray ionization ; high-performance liquid chromatography ; mass spectrometry
刊名: EUROPEAN JOURNAL OF MASS SPECTROMETRY
发表日期: 2012
DOI: 10.1255/ejms.1169
卷: 18, 期:1, 页:59-69
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Physics, Atomic, Molecular & Chemical ; Spectroscopy
研究领域[WOS]: Physics ; Spectroscopy
关键词[WOS]: FINGERPRINT ANALYSIS ; ANGELICA-DAHURICA ; FUROCOUMARINS ; CONSTITUENTS ; IDENTIFICATION ; FORBESII ; EXTRACT ; HPLC ; MSN
英文摘要:

Notopterygium incisum Ting ex H.T. Chang (N. incisum) and Notopterygium forbesii Boiss (N. forbesii) are two medicinal species of Qianghuo (a well-known traditional herbal medicine in China) that are widely used in clinical prescriptions for the treatment of colds and rheumatism. To compare the chemical constituents of these two plant materials, the phenolic constituents and coumarins of these two species were comprehensively and systematically analyzed by high-performance liquid chromatography-photodiode array detection-electrospray ionization tandem mass spectrometry (HPLC/DAD/ESI-MSn) for the first time. A total of 25 compounds (nine phenolic compounds and 16 coumarins) were detected in the methanol extracts. These compounds were separated on a C18 column and identified or tentatively characterized on the basis of their UV spectra and MS fragmentation behavior. In contrast to previous reports, we found that these two plant species possess very different coumarin patterns. 0-Demethylfuropinnarin (18), phenethytferulate (19), notopterol (20), and isoimperatorin (22) were the predominant constituents of N. incisum, whereas nodakenin (6), 6-0-trans-feruloylnodakenin (12), p-hydroxypenethylanisate (16) and isoimperatorin (22) were the major constituents of N. forbesii. 0-Demethylfuropinnarin (18), phenethylferulate (19) and notopterol (20) were only detected in N. incisum and can be regarded as useful taxonomic markers for differentiating these two plant species. Considering the marked differences in the main chemical constituents of N. incisum and N. forbesii, the biological activities of these two species should be further investigated and compared to ensure consistency and efficacy in the pharmaceutical applications of these materials.

语种: 英语
WOS记录号: WOS:000303263400005
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66147
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Shimadzu Int Trading Shanghai Co Ltd, Beijing Off, Beijing 100020, Peoples R China

Recommended Citation:
Liu, Guo-Qang,Dong, Jing,Wang, Hong,et al. Comparison of two species of Notopterygium by high-performance Liquid chromatography-photodiode array detection-electrospray ionization tandem mass spectrometry[J]. EUROPEAN JOURNAL OF MASS SPECTROMETRY,2012,18(1):59-69.
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