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学科主题: 药学
题名:
Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II
作者: Zhang, Ying; Yang, Dong-Hui; Zhang, Ying-Tao; Chen, Xiu-Min; Li, Li-Li; Cai, Shao-Qing
关键词: Biotransformation ; Flavonolignan ; Silybi Fructus ; Eubacterium limosum ZL-II ; Alzheimer&prime ; s A beta(42) ; Tumor cell
刊名: FITOTERAPIA
发表日期: 2014
DOI: 10.1016/j.fitote.2013.10.001
卷: 92, 页:61-71
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]: Pharmacology & Pharmacy
关键词[WOS]: TANDEM MASS-SPECTROMETRY ; MILK THISTLE ; HUMAN PROSTATE ; SILIBININ ; MARIANUM ; CHROMATOGRAPHY ; CANCER ; SILYCHRISTIN ; SILYMARIN ; CELLS
英文摘要:

Eubacterium limosum ZL-II is an anaerobic bacterium with demethylated activity, which was isolated from human intestinal bacteria in our previous work. In this study, the flavonolignan constituents of Silybi Fructus were biotransformed by E. limosum(1) ZL-II, producing four new transformation products - demethylisosilybin B (T1), demethylisosilybin A (T2), demethylsilybin B (T3) and demethylsilybin A (T4), among which T1 and T2 were new compounds. Their chemical structures were identified by ESI-TOF/MS, H-1 NMR, C-13 NMR, HMBC and CD spectroscopic data. The bioassay results showed that the transformation products T1-T4 exhibited significant inhibitory activities on Alzheimer′s amyloid-beta 42 (A beta(2)(42)) aggregation with IC50 values at 7.49 mu M-10.46 mu M, which were comparable with that of the positive control (epigallocatechin gallate, EGCG(3), at 9.01 mu M) and much lower than those of their parent compounds (at not less than 145.10 mu M). The method of biotransformation by E. limosum ZL-II explored a way to develop the new and active lead compounds in Alzheimer′s disease from Silybi Fructus. However, the transformation products T1-T4 exhibited decreased inhibitory activities against human tumor cell lines comparing with their parent compounds. (C) 2013 Elsevier B.V. All rights reserved.

语种: 英语
所属项目编号: 21072012 ; 2011ZX09102-011-06 ; 20100001110059
项目资助者: National Natural Science Foundation of China ; National Science and Technology Major Projects for Major New Drugs Innovation and Development of China ; Ministry of Education of China
WOS记录号: WOS:000331420300008
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66150
Appears in Collections:北京大学药学院_期刊论文

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作者单位: Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China

Recommended Citation:
Zhang, Ying,Yang, Dong-Hui,Zhang, Ying-Tao,et al. Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II[J]. FITOTERAPIA,2014,92:61-71.
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