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Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II
Zhang, Ying; Yang, Dong-Hui; Zhang, Ying-Tao; Chen, Xiu-Min; Li, Li-Li; Cai, Shao-Qing
关键词Biotransformation Flavonolignan Silybi Fructus Eubacterium limosum ZL-II Alzheimer&prime s A beta(42) Tumor cell
刊名FITOTERAPIA
2014
DOI10.1016/j.fitote.2013.10.001
92页:61-71
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Chemistry, Medicinal ; Pharmacology & Pharmacy
研究领域[WOS]Pharmacology & Pharmacy
关键词[WOS]TANDEM MASS-SPECTROMETRY ; MILK THISTLE ; HUMAN PROSTATE ; SILIBININ ; MARIANUM ; CHROMATOGRAPHY ; CANCER ; SILYCHRISTIN ; SILYMARIN ; CELLS
英文摘要

Eubacterium limosum ZL-II is an anaerobic bacterium with demethylated activity, which was isolated from human intestinal bacteria in our previous work. In this study, the flavonolignan constituents of Silybi Fructus were biotransformed by E. limosum(1) ZL-II, producing four new transformation products - demethylisosilybin B (T1), demethylisosilybin A (T2), demethylsilybin B (T3) and demethylsilybin A (T4), among which T1 and T2 were new compounds. Their chemical structures were identified by ESI-TOF/MS, H-1 NMR, C-13 NMR, HMBC and CD spectroscopic data. The bioassay results showed that the transformation products T1-T4 exhibited significant inhibitory activities on Alzheimer′s amyloid-beta 42 (A beta(2)(42)) aggregation with IC50 values at 7.49 mu M-10.46 mu M, which were comparable with that of the positive control (epigallocatechin gallate, EGCG(3), at 9.01 mu M) and much lower than those of their parent compounds (at not less than 145.10 mu M). The method of biotransformation by E. limosum ZL-II explored a way to develop the new and active lead compounds in Alzheimer′s disease from Silybi Fructus. However, the transformation products T1-T4 exhibited decreased inhibitory activities against human tumor cell lines comparing with their parent compounds. (C) 2013 Elsevier B.V. All rights reserved.

语种英语
WOS记录号WOS:000331420300008
项目编号21072012 ; 2011ZX09102-011-06 ; 20100001110059
资助机构National Natural Science Foundation of China ; National Science and Technology Major Projects for Major New Drugs Innovation and Development of China ; Ministry of Education of China
引用统计
被引频次:2[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66150
专题北京大学药学院
北京大学药学院_天然药物学系
作者单位Peking Univ, Sch Pharmaceut Sci, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
推荐引用方式
GB/T 7714
Zhang, Ying,Yang, Dong-Hui,Zhang, Ying-Tao,et al. Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II[J]. FITOTERAPIA,2014,92:61-71.
APA Zhang, Ying,Yang, Dong-Hui,Zhang, Ying-Tao,Chen, Xiu-Min,Li, Li-Li,&Cai, Shao-Qing.(2014).Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II.FITOTERAPIA,92,61-71.
MLA Zhang, Ying,et al."Biotransformation on the flavonolignan constituents of Silybi Fructus by an intestinal bacterial strain Eubacterium limosum ZL-II".FITOTERAPIA 92(2014):61-71.
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