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学科主题: 临床医学
题名:
A Novel High Nitrogen Nickel-free Coronary Stents System: Evaluation in a Porcine Model
作者: Zhang Bin; Chen Ming; Zheng Bo; Wang Xin Gang; Wang Xi Ting; Fan Yuan Yuan; Huo Yong
关键词: Austenitic steel ; Bare metal stent ; Endothelialization ; Restenosis ; Stent thrombosis
刊名: BIOMEDICAL AND ENVIRONMENTAL SCIENCES
发表日期: 2014-04-01
DOI: 10.3967/bes2014.051
卷: 27, 期:4, 页:289-294
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Environmental Sciences ; Public, Environmental & Occupational Health
研究领域[WOS]: Environmental Sciences & Ecology ; Public, Environmental & Occupational Health
关键词[WOS]: DRUG-ELUTING STENTS ; CARCINOGENICITY ; RESTENOSIS ; TOXICITY ; OUTCOMES ; TRIAL
英文摘要:

Objective To study the safety of the novel high nitrogen nickel-free austenitic stainless steel bare metal stents (BMS) in a recognized porcine coronary model and to select a better grid structure of it.

Methods Three types of stents were randomly implanted in different coronary arteries of the same pig: 316L stainless steel BMS (316L-BMS) (n=12), novel high nitrogen nickel-free stents Grid A (NF-A-BMS) (n=12) and novel high nitrogen nickel-free stents Grid B (NF-B-BMS) (n=12). In total, eighteen animals underwent successful random placement of 36 oversized stents in the coronary arteries. Coronary angiography was performed after 36 d of stents implantation. Nine animals were respectively sacrificed after 14 d and 36 d for histomorphologic analysis.

Results Quantitative coronary angiography (QCA) showed similar lumina! loss (LL) in the three groups: (0.21 +/- 0.17) mm for 316L-BMS, (0.16 +/- 0.12) mm for NF-A-BMS, (0.24 +/- 0.15) mm for NF-B-BMS (P>0.05). Histomorphomeric analysis after 15 d and 36 d revealed that there was also no significant difference among the three groups in neointimal area (NA) with similar injury scores respectively. High magnification histomorphologic examination showed similar inflammation scores in the three groups, but NF-A-BMS group had poorer endothelialization scores compared with NF-B-BMS group, 2.00 +/- 0.63 vs. 2.83 +/- 0.41 (P=0.015) at 15 d, which also could be proved by the scanning electron microscope. However, the difference could not been observed at 36 d.

Conclusion The novel NF-BMS showed similar safety as 316L-BMS during the short-term study. NF-B-BMS had better endothelialization than NF-A-BMS and this may owe to the specific strut units.

语种: 英语
WOS记录号: WOS:000334935300007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66153
Appears in Collections:北京大学第一临床医学院_心血管内科_期刊论文

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作者单位: Peking Univ, Hosp 1, Dept Cardiol, Beijing 100034, Peoples R China

Recommended Citation:
Zhang Bin,Chen Ming,Zheng Bo,et al. A Novel High Nitrogen Nickel-free Coronary Stents System: Evaluation in a Porcine Model[J]. BIOMEDICAL AND ENVIRONMENTAL SCIENCES,2014,27(4):289-294.
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