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学科主题: 药学
题名:
Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities
作者: Zhang, Guo-Liang1,2,3; Chen, Changshui3; Xiong, Yulan1; Zhang, Li-He1,2; Ye, Jia1; Ye, Xin-Shan1,2
关键词: Iminosugar ; Synthesis ; Alkylation ; Immunosuppressive agent ; MTT assay
刊名: CARBOHYDRATE RESEARCH
发表日期: 2010-04-19
DOI: 10.1016/j.carres.2010.01.021
卷: 345, 期:6, 页:780-786
收录类别: SCI ; IC
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Biochemistry & Molecular Biology ; Chemistry, Applied ; Chemistry, Organic
研究领域[WOS]: Biochemistry & Molecular Biology ; Chemistry
关键词[WOS]: LYSOSOMAL ALPHA-GALACTOSIDASE ; TYPE-2 DIABETES-MELLITUS ; VIRAL DIARRHEA VIRUS ; HEPATITIS-C VIRUS ; BIOLOGICAL EVALUATION ; FABRY LYMPHOBLASTS ; INHIBITORS ; AGENTS ; TRANSPLANTATION ; SECRETION
英文摘要:

Several N-alkyl and hydroxyethyl-substituted iminosugar derivatives, including L-altro and D-galacto epimers, were synthesized and the effects of these synthetic iminosugars on proliferation of mouse splenocytes were evaluated in the MTT assay. The experimental data demonstrated that the N-alkylated D-galacto iminosugars showed better inhibitory activities than L-altro analogues, which might hold potential as immunosuppressive agents. (C) 2010 Elsevier Ltd. All rights reserved.

语种: 英语
项目资助者: National Natural Science Foundation of China
WOS记录号: WOS:000277112800007
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66156
Appears in Collections:北京大学药学院_期刊论文

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作者单位: 1.Peking Univ, Sch Pharmaceut Sci, Beijing 100191, Peoples R China
2.Peking Univ, State Key Lab Nat & Biomimet Drugs, Beijing 100191, Peoples R China
3.Huazhong Agr Univ, Coll Basic Sci, Wuhan 430070, Peoples R China

Recommended Citation:
Zhang, Guo-Liang,Chen, Changshui,Xiong, Yulan,et al. Synthesis of N-substituted iminosugar derivatives and their immunosuppressive activities[J]. CARBOHYDRATE RESEARCH,2010,345(6):780-786.
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