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Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: Preparation, freeze-drying, and in vitro release
Yang, Zhuo Li; Li, Xin Ru; Yang, Ke Wei; Liu, Yan
关键词poly(ethylene glycol)-poly(lactide) micelles redispersibility freeze-drying in vitro release
刊名JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A
2008-05-01
DOI10.1002/jbm.a.31504
85A期:2页:539-546
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Engineering, Biomedical ; Materials Science, Biomaterials
研究领域[WOS]Engineering ; Materials Science
关键词[WOS]SOLID LIPID NANOPARTICLES ; DRUG-DELIVERY ; POLYMERIC MICELLES ; LYOPHILIZATION ; CARRIERS ; SOLUBILIZATION ; STABILIZATION ; COMPATIBILITY ; LIPOSOMES ; SYSTEMS
英文摘要

Polymeric micelles prepared from a series of poly(ethylene glycol)-poly(lactide) (PEG-PLA) diblock copolymers with various PLA chain lengths were designed as drug carriers for water insoluble drug amphotericin B (AmB). Physicochemical properties of AmB-loaded micelles were evaluated. Micelles were freeze-dried to obtain longtime stable formulations. The redispersibility of the freeze-dried samples was poor when the weight ratio of PLA block was bigger than the PEG block of the copolymer. Various types of lyoprotectants including saccharides and PEGs with different molecular weight were tested to improve the redispersion performance of the freeze-dried samples. PEG was proved to be more effective than saccharides on stabilizing the micelles during lyophilization when the weight ratio of PLA block was bigger than PEG block. The sustained release in vitro of AmB was evidenced. About 80% of AmB was released in 80 h. The in vitro release behavior could be best described by the first-order equation. The release rate was reduced as enhancing PLA chain length due to the stronger interaction between poorly water-soluble AmB and longer hydrophobic chain length of PLA. (C) 2007 Wiley Periodicals, Inc.

语种英语
WOS记录号WOS:000254801700028
引用统计
被引频次:38[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66158
专题北京大学药学院_药剂学系
作者单位Peking Univ, Sch Pharmaceut Sci, Dept Pharmaceut, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yang, Zhuo Li,Li, Xin Ru,Yang, Ke Wei,et al. Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: Preparation, freeze-drying, and in vitro release[J]. JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,2008,85A(2):539-546.
APA Yang, Zhuo Li,Li, Xin Ru,Yang, Ke Wei,&Liu, Yan.(2008).Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: Preparation, freeze-drying, and in vitro release.JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A,85A(2),539-546.
MLA Yang, Zhuo Li,et al."Amphotericin B-loaded poly(ethylene glycol)-poly(lactide) micelles: Preparation, freeze-drying, and in vitro release".JOURNAL OF BIOMEDICAL MATERIALS RESEARCH PART A 85A.2(2008):539-546.
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