学科主题基础医学
Association between Three Genetic Variants of the Perilipin Gene (PLIN) and Glucose Metabolism: Results from a Replication Study among Chinese Adults and a Meta-Analysis
Yu, Dahai1,2; Li, Chunyang3; Xie, Jing1,4; Xu, Guoheng5; Li, Yanyan3; Liu, Jiyan3; Chen, Bing3; Pan, Jingjing3; Shen, Minghui3; Yang, Liming3; Hu, Dongsheng1
关键词Diabetes Obesity Perilipin Single nucleoside polymorphisms Chinese
刊名ENDOCRINE RESEARCH
2013
DOI10.3109/07435800.2013.778864
38期:4页:263-279
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Endocrinology & Metabolism
研究领域[WOS]Endocrinology & Metabolism
关键词[WOS]WEIGHT-LOSS ; CARDIOVASCULAR-DISEASE ; CENTRAL OBESITY ; RAT ADIPOCYTES ; RISK ; POLYMORPHISMS ; POPULATION ; HAPLOTYPE ; LOCUS ; WOMEN
英文摘要

Objective. This study was aimed to replicate the associations between three Perilipin Gene (PLIN) variants (rs894160, rs1052700, and rs2304796) and diabetes risks and to evaluate the overall effects of these variants on diabetes risk and obesity risk. Methods. We conducted a cross-sectional study among 993 Chinese Han adults. We also made a meta-analysis to estimate associations between these variants and diabetes risk and obesity risk. Results. In the sample of all participants, all three single-nucleotide polymorphisms (SNPs) were not significantly associated with diabetes risks. The PLIN polymorphisms significantly interacted with central obesity in relation to diabetes risk (P for interaction = 0.036, 0.033, and 0.042 for rs1052700, rs894160, and rs2304796, respectively). In those with allele T of rs1052700 or allele A of rs894160, fasting glucose concentration and diabetes risk increased significantly with the increment of waist circumference. Only association between rs894160 and obesity risk was available for meta-analysis. The meta-analysis indicated the overall estimation of obesity risk for rs894160 was 0.97 (0.78, 1.16) among participants with allele A versus people with genotype GG and 1.46 (0.99, 1.93) among those with genotype AA versus allele G carriers. Conclusion. Chinese adults with high waist circumference may have a high risk of diabetes, especially among those with allele T in rs1052700 or with allele A in rs894160. People with genotype AA (rs894160) may have a high risk of obesity.

语种英语
WOS记录号WOS:000325097400008
项目编号30671805 ; 2006KYCX010
资助机构Chinese National Natural Scientific Research Foundation ; Henan Innovation Project for University Prominent Research Talents
引用统计
被引频次:4[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66160
专题北京大学基础医学院_生理学与病理生理学系
北京大学基础医学院
作者单位1.Shenzhen Univ, Dept Prevent Med, Sch Med, Shenzhen 518060, Guangdong, Peoples R China
2.Cambridge Univ Hosp NHS Fdn Trust, Inst Metab Sci, Cambridge CB2 0QQ, England
3.Zhengzhou Univ, Dept Epidemiol, Coll Publ Hlth, Zhengzhou 450001, Henan, Peoples R China
4.Univ Melbourne, Ctr Eye Res Australia, Populat Hlth Unit, East Melbourne, Vic 3002, Australia
5.Beijing Univ, Dept Physiol, Med Sci Ctr, Beijing 100083, Peoples R China
推荐引用方式
GB/T 7714
Yu, Dahai,Li, Chunyang,Xie, Jing,et al. Association between Three Genetic Variants of the Perilipin Gene (PLIN) and Glucose Metabolism: Results from a Replication Study among Chinese Adults and a Meta-Analysis[J]. ENDOCRINE RESEARCH,2013,38(4):263-279.
APA Yu, Dahai.,Li, Chunyang.,Xie, Jing.,Xu, Guoheng.,Li, Yanyan.,...&Hu, Dongsheng.(2013).Association between Three Genetic Variants of the Perilipin Gene (PLIN) and Glucose Metabolism: Results from a Replication Study among Chinese Adults and a Meta-Analysis.ENDOCRINE RESEARCH,38(4),263-279.
MLA Yu, Dahai,et al."Association between Three Genetic Variants of the Perilipin Gene (PLIN) and Glucose Metabolism: Results from a Replication Study among Chinese Adults and a Meta-Analysis".ENDOCRINE RESEARCH 38.4(2013):263-279.
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