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学科主题: 基础医学
题名:
Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K-ATP channels
作者: Zhang, Zhifei1; Huang, Haixia1; Liu, Ping1; Tang, Chaoshu2; Wang, Jun1
关键词: hydrogen sulfide ; K-ATP channel ; ischemia-reperfusion injury ; patch clamp
刊名: CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY
发表日期: 2007-12-01
DOI: 10.1139/Y07-120
卷: 85, 期:12, 页:1248-1253
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Pharmacology & Pharmacy ; Physiology
研究领域[WOS]: Pharmacology & Pharmacy ; Physiology
关键词[WOS]: RAT ; H2S ; MYOCYTES ; LIVER ; HEART
英文摘要:

The present study was undertaken to investigate the protective effect of H2S against myocardial ischemia-reperfusion (I/R) injury and its possible mechanism by using isolated heart perfusion and patch clamp recordings. Rat isolated hearts were Langendorff-perfused and subjected to a 30-minute ischemia insult followed by a 30-minute reperfusion. The heart function was assessed by measuring the LVDP, +/- dP/dt(max), and the arrhythmia score. The results showed that the treatment of hearts with a H)S donor (40 mu mol/L NaHS) during reperfusion resulted in significant improvement in heart function compared with the I/R group (LVDP recovered to 85.0% +/- 6.4% vs. 35.0% +/- 6.1%. +dP/dt(max) recovered to 80.9% +/- 4.2% vs. 43.0% +/- 6.4%, and -dP/dt(max) recovered to 87.4% +/- 7.3% vs. 53.8% +/- 4.9%; p < 0.01). The arrhythmia scores also improved in the NaHS group compared with the I/R group (1.5 +/- 0.2 vs. 4.0 +/- 0.4, respectively, p < 0.001). The cardioprotective effect of NaHS during reperfusion could be blocked by an ATP-sensitive potassium channel (K-ATP) blocker (10 mu mol/L glibenclamide). In single cardiac myocytes, NaHS increased the open probability of KATP channels from 0.07 +/- 0.03 to 0.15 +/- 0.08 after application of 40 mu mol/L NaHS and from 0.07 +/- 0.03 to 0.36 +/- 0.15 after application of 100 mu mol/L NaHS. These findings provide the first evidence that H2S increases the open probability of KATP in cardiac myocytes, which may be responsible for cardioprotection against I/R injury during reperfusion.

语种: 英语
WOS记录号: WOS:000252714700005
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66164
Appears in Collections:基础医学院_生理学与病理生理学系_期刊论文

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作者单位: 1.Capital Med Univ, Sch Basic Med Sci, Dept Physiol, Beijing, Peoples R China
2.Peking Univ, Hlth Sci Ctr, Dept Physiol, Beijing 100871, Peoples R China

Recommended Citation:
Zhang, Zhifei,Huang, Haixia,Liu, Ping,et al. Hydrogen sulfide contributes to cardioprotection during ischemia-reperfusion injury by opening K-ATP channels[J]. CANADIAN JOURNAL OF PHYSIOLOGY AND PHARMACOLOGY,2007,85(12):1248-1253.
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