IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Glycyrrhetinic Acid Protects the Heart from Ischemia/Reperfusion Injury by Attenuating the Susceptibility and Incidence of Fatal Ventricular Arrhythmia During the Reperfusion Period in the Rat Hearts
Wu, Hong-Jin1; Yang, Ji-Yuan2; Jin, Min2; Wang, Sheng-Qi3; Wu, De-Lin2; Liu, Yu-Na2; Yan, Xu1,4; Yang, Cui1; Zhang, Ge1; He, Jing1
关键词Glycyrrhetinic acid Ischemia/reperfusion Arrhythmias Ion channel
刊名CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
2015-05-01
DOI10.1159/000430134
36期:2页:741-752
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Cell Biology ; Physiology
研究领域[WOS]Cell Biology ; Physiology
关键词[WOS]18-BETA-GLYCYRRHETINIC ACID ; CELLULAR MECHANISMS ; ATRIAL-FIBRILLATION ; CORONARY-OCCLUSION ; ISCHEMIA ; MYOCARDIUM ; ACTIVATION ; GLYCYRRHIZIN ; INFARCTION ; MUTATIONS
英文摘要

Background/Aims: Licorice has been used to treat many diseases, including palpitations, in both Eastern and Western societies for thousands of years. It has been reported that glycyrrhetinic acid (GA), an aglycone saponin extracted from licorice root, exerts protective effects on the cardiovascular system, limits infarct sizes and protects against the development of arrhythmia. However, the mechanisms underlying the effects of glycyrrhetinic acid on the cardiovascular system remain poorly understood. This study aimed to determine the mechanisms underlying the protective effects of GA against lethal cardiac arrhythmias induced via ischemia-reperfusion in rat hearts, and to examine its electropharmacological properties. Materials and Methods: Anesthetized rats were divided into control (CTL), GA5, GA10, and GA20 groups. GA was administered intravenously 15 min before the occlusion of the left anterior descending coronary artery, at dosages of 5, 10 and 20 mg/kg, respectively. Single ventricular myocytes were isolated using enzymolysis. The whole-cell patch clamp technique was utilized to record Ica, L, Ito and action potentials (APs). Results: During reperfusion, the incidence of ventricular fibrillation (VF) was decreased in each of the groups compared with the CTL group (p<0.05). The ventricular tachycardia (VT)/VF score was significantly decreased in the GA20 group. Action potential durations (APDs) were prolonged by GA; both L-type calcium current (Ica-L) and transient outward potassium current (Ito) were blocked in a concentration-dependent manner by GA. Conclusion: These results suggest that GA attenuates both the susceptibility to and the incidence of fatal ventricular arrhythmia during reperfusion in rat hearts via the prolongation of the APD and the inhibition of both Ica-L and Ito. GA appears to be a promising antiarrhythmic agent in the setting of ischemia/reperfusion. Copyright (C) 2015 S. Karger AG, Basel

语种英语
WOS记录号WOS:000355944000027
引用统计
被引频次:9[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66167
专题北京大学第三临床医学院
作者单位1.Beijing Inst Radiat Med, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Beijing Haidian Hosp, Haidian Sect, Beijing 100080, Peoples R China
3.Beijing Hosp Integrated Tradit Chinese & Western, Beijing, Peoples R China
4.Zhongguancun Haidian Sci Pk, Postdoctoral Workstn, Beijing, Peoples R China
推荐引用方式
GB/T 7714
Wu, Hong-Jin,Yang, Ji-Yuan,Jin, Min,et al. Glycyrrhetinic Acid Protects the Heart from Ischemia/Reperfusion Injury by Attenuating the Susceptibility and Incidence of Fatal Ventricular Arrhythmia During the Reperfusion Period in the Rat Hearts[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2015,36(2):741-752.
APA Wu, Hong-Jin.,Yang, Ji-Yuan.,Jin, Min.,Wang, Sheng-Qi.,Wu, De-Lin.,...&He, Jing.(2015).Glycyrrhetinic Acid Protects the Heart from Ischemia/Reperfusion Injury by Attenuating the Susceptibility and Incidence of Fatal Ventricular Arrhythmia During the Reperfusion Period in the Rat Hearts.CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,36(2),741-752.
MLA Wu, Hong-Jin,et al."Glycyrrhetinic Acid Protects the Heart from Ischemia/Reperfusion Injury by Attenuating the Susceptibility and Incidence of Fatal Ventricular Arrhythmia During the Reperfusion Period in the Rat Hearts".CELLULAR PHYSIOLOGY AND BIOCHEMISTRY 36.2(2015):741-752.
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