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学科主题: 临床医学
题名:
Glycyrrhetinic Acid Protects the Heart from Ischemia/Reperfusion Injury by Attenuating the Susceptibility and Incidence of Fatal Ventricular Arrhythmia During the Reperfusion Period in the Rat Hearts
作者: Wu, Hong-Jin1; Yang, Ji-Yuan2; Jin, Min2; Wang, Sheng-Qi3; Wu, De-Lin2; Liu, Yu-Na2; Yan, Xu1,4; Yang, Cui1; Zhang, Ge1; He, Jing1
关键词: Glycyrrhetinic acid ; Ischemia/reperfusion ; Arrhythmias ; Ion channel
刊名: CELLULAR PHYSIOLOGY AND BIOCHEMISTRY
发表日期: 2015-05-01
DOI: 10.1159/000430134
卷: 36, 期:2, 页:741-752
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Cell Biology ; Physiology
研究领域[WOS]: Cell Biology ; Physiology
关键词[WOS]: 18-BETA-GLYCYRRHETINIC ACID ; CELLULAR MECHANISMS ; ATRIAL-FIBRILLATION ; CORONARY-OCCLUSION ; ISCHEMIA ; MYOCARDIUM ; ACTIVATION ; GLYCYRRHIZIN ; INFARCTION ; MUTATIONS
英文摘要:

Background/Aims: Licorice has been used to treat many diseases, including palpitations, in both Eastern and Western societies for thousands of years. It has been reported that glycyrrhetinic acid (GA), an aglycone saponin extracted from licorice root, exerts protective effects on the cardiovascular system, limits infarct sizes and protects against the development of arrhythmia. However, the mechanisms underlying the effects of glycyrrhetinic acid on the cardiovascular system remain poorly understood. This study aimed to determine the mechanisms underlying the protective effects of GA against lethal cardiac arrhythmias induced via ischemia-reperfusion in rat hearts, and to examine its electropharmacological properties. Materials and Methods: Anesthetized rats were divided into control (CTL), GA5, GA10, and GA20 groups. GA was administered intravenously 15 min before the occlusion of the left anterior descending coronary artery, at dosages of 5, 10 and 20 mg/kg, respectively. Single ventricular myocytes were isolated using enzymolysis. The whole-cell patch clamp technique was utilized to record Ica, L, Ito and action potentials (APs). Results: During reperfusion, the incidence of ventricular fibrillation (VF) was decreased in each of the groups compared with the CTL group (p<0.05). The ventricular tachycardia (VT)/VF score was significantly decreased in the GA20 group. Action potential durations (APDs) were prolonged by GA; both L-type calcium current (Ica-L) and transient outward potassium current (Ito) were blocked in a concentration-dependent manner by GA. Conclusion: These results suggest that GA attenuates both the susceptibility to and the incidence of fatal ventricular arrhythmia during reperfusion in rat hearts via the prolongation of the APD and the inhibition of both Ica-L and Ito. GA appears to be a promising antiarrhythmic agent in the setting of ischemia/reperfusion. Copyright (C) 2015 S. Karger AG, Basel

语种: 英语
所属项目编号: JZZ-312 ; 30672586
项目资助者: Beijing Key Disciplines Project of Traditional Chinese Medicine ; Chinese National Natural Science Foundation
WOS记录号: WOS:000355944000027
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66167
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Beijing Inst Radiat Med, Beijing, Peoples R China
2.Peking Univ, Hosp 3, Beijing Haidian Hosp, Haidian Sect, Beijing 100080, Peoples R China
3.Beijing Hosp Integrated Tradit Chinese & Western, Beijing, Peoples R China
4.Zhongguancun Haidian Sci Pk, Postdoctoral Workstn, Beijing, Peoples R China

Recommended Citation:
Wu, Hong-Jin,Yang, Ji-Yuan,Jin, Min,et al. Glycyrrhetinic Acid Protects the Heart from Ischemia/Reperfusion Injury by Attenuating the Susceptibility and Incidence of Fatal Ventricular Arrhythmia During the Reperfusion Period in the Rat Hearts[J]. CELLULAR PHYSIOLOGY AND BIOCHEMISTRY,2015,36(2):741-752.
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