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学科主题: 临床医学
题名:
Dynamics of inflammation resolution and symptom recovery during AECOPD treatment
作者: Chang, Chun1; Guo, Zhiguo2; Shen, Ning1; He, Bei1; Yao, Wanzhen1; Zhu, Hong1; Zhao, Jiangchao3
刊名: SCIENTIFIC REPORTS
发表日期: 2014-07-01
DOI: 10.1038/srep05516
卷: 4
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: OBSTRUCTIVE PULMONARY-DISEASE ; C-REACTIVE PROTEIN ; AIRWAY INFLAMMATION ; PHYSIOLOGICAL-CHANGES ; SEVERE EXACERBATIONS ; COPD EXACERBATIONS ; INDUCED SPUTUM ; BIOMARKERS ; PREDICTORS ; COPEPTIN
英文摘要:

The association between increases in both systemic and airway inflammation and acute exacerbation of COPD (AECOPD) has been reported by many studies. However, relatively little is known about the dynamics of inflammation resolution and their correlations with the improvement of clinical indices during treatment. In this study, a total of 93 consecutively hospitalized patients with AECOPD were recruited. Sputum and serum inflammatory markers were measured on the day of admission before treatment (day 0), day 4, 7 and 14 during treatment as well as 8 weeks after discharge. Clinical indices (lung function, dyspnea and COPD assessment test (CAT) scores) were also measured at those time points. By day 4, all airway inflammatory measures rapidly decreased and returned to baseline level. Notably, lung function and dyspnea improved to the baseline level by day 4 as well, consistent with the resolution of respiratory inflammation. However, despite the significant decrease by day 4, systemic inflammation did not reach baseline until day 14, concordant with the decrease in CAT score. In summary, we observed a time lag between the resolution of systemic and airway inflammation, which were correlated with the improvements of different clinical indices.

语种: 英语
所属项目编号: 07010440052
项目资助者: Chinese Medical Association for the scientific research of chronic respiratory tract diseases
WOS记录号: WOS:000338420400001
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66168
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Resp Med, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Dept Emergency Med, Beijing 100871, Peoples R China
3.Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA

Recommended Citation:
Chang, Chun,Guo, Zhiguo,Shen, Ning,et al. Dynamics of inflammation resolution and symptom recovery during AECOPD treatment[J]. SCIENTIFIC REPORTS,2014,4.
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