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学科主题临床医学
Dynamics of inflammation resolution and symptom recovery during AECOPD treatment
Chang, Chun1; Guo, Zhiguo2; Shen, Ning1; He, Bei1; Yao, Wanzhen1; Zhu, Hong1; Zhao, Jiangchao3
刊名SCIENTIFIC REPORTS
2014-07-01
DOI10.1038/srep05516
4
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Multidisciplinary Sciences
研究领域[WOS]Science & Technology - Other Topics
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; C-REACTIVE PROTEIN ; AIRWAY INFLAMMATION ; PHYSIOLOGICAL-CHANGES ; SEVERE EXACERBATIONS ; COPD EXACERBATIONS ; INDUCED SPUTUM ; BIOMARKERS ; PREDICTORS ; COPEPTIN
英文摘要

The association between increases in both systemic and airway inflammation and acute exacerbation of COPD (AECOPD) has been reported by many studies. However, relatively little is known about the dynamics of inflammation resolution and their correlations with the improvement of clinical indices during treatment. In this study, a total of 93 consecutively hospitalized patients with AECOPD were recruited. Sputum and serum inflammatory markers were measured on the day of admission before treatment (day 0), day 4, 7 and 14 during treatment as well as 8 weeks after discharge. Clinical indices (lung function, dyspnea and COPD assessment test (CAT) scores) were also measured at those time points. By day 4, all airway inflammatory measures rapidly decreased and returned to baseline level. Notably, lung function and dyspnea improved to the baseline level by day 4 as well, consistent with the resolution of respiratory inflammation. However, despite the significant decrease by day 4, systemic inflammation did not reach baseline until day 14, concordant with the decrease in CAT score. In summary, we observed a time lag between the resolution of systemic and airway inflammation, which were correlated with the improvements of different clinical indices.

语种英语
WOS记录号WOS:000338420400001
项目编号07010440052
资助机构Chinese Medical Association for the scientific research of chronic respiratory tract diseases
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66168
专题北京大学第三临床医学院_呼吸科
北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Hosp 3, Dept Resp Med, Beijing 100871, Peoples R China
2.Peking Univ, Hosp 3, Dept Emergency Med, Beijing 100871, Peoples R China
3.Univ Michigan, Dept Pediat & Communicable Dis, Ann Arbor, MI 48109 USA
推荐引用方式
GB/T 7714
Chang, Chun,Guo, Zhiguo,Shen, Ning,et al. Dynamics of inflammation resolution and symptom recovery during AECOPD treatment[J]. SCIENTIFIC REPORTS,2014,4.
APA Chang, Chun.,Guo, Zhiguo.,Shen, Ning.,He, Bei.,Yao, Wanzhen.,...&Zhao, Jiangchao.(2014).Dynamics of inflammation resolution and symptom recovery during AECOPD treatment.SCIENTIFIC REPORTS,4.
MLA Chang, Chun,et al."Dynamics of inflammation resolution and symptom recovery during AECOPD treatment".SCIENTIFIC REPORTS 4(2014).
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