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学科主题临床医学
Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD
Zhang, Jing1; Wang, Xinmao2; Chen, Yahong1; Yao, Wanzhen1
关键词chronic obstructive pulmonary disease airway inflammation phenotype eosinophilia hydrogen sulfide
刊名RESPIRATORY CARE
2015-02-01
DOI10.4187/respcare.03519
60期:2页:251-258
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Critical Care Medicine ; Respiratory System
研究领域[WOS]General & Internal Medicine ; Respiratory System
关键词[WOS]OBSTRUCTIVE PULMONARY-DISEASE ; CHRONIC-BRONCHITIS ; SPUTUM-EOSINOPHILIA ; SODIUM SULFIDE ; ASTHMA ; EXACERBATIONS ; DYSPNEA ; HEALTHY ; GAS
英文摘要

BACKGROUND: The role of exhaled H2S as a marker of airway inflammation and its relationship with COPD severity remain to be determined. METHODS: Airway inflammation was classified in 77 COPD subjects based on the presence of inflammatory cells in induced sputum. We investigated the association between disease phenotype and exhaled H2S, lung function, and plasma levels of several inflammatory factors, including tumor necrosis factor alpha, interleukin-8, and leukotriene B-4. RESULTS: In total, 33.77% of enrolled COPD subjects were diagnosed with eosinophilia. These subjects had a longer disease course, smoked fewer cigarettes, and experienced more frequent exacerbation events before study enrollment. However, they also had worse lung function and larger residual volume, they demonstrated greater changes in FEV1, following bronchodilator inhalation. Although levels of plasma inflammatory factors did not significantly differ between subjects with and without eosinophilia, subjects without eosinophilia had significantly higher levels of exhaled H2S (9.19 +/- 2.74 vs 7.24 +/- 1.68 parts per billion, P = .01). Furthermore, exhaled H2S levels were negatively correlated with induced sputum eosinophils (r = 0.45, P = .05), and positively correlated with inspiratory capacity in COPD subjects (r = 0.51, P = .026), but did not correlate significantly with plasma inflammatory factors. A cut-off value of 7.10 parts per billion of exhaled H2S predicted a non-eosinophilic phenotype with 68.6% sensitivity and 77.9% specificity. CONCLUSIONS: Exhaled levels of H2S were lower in subjects with eosinophilia. Increased levels of exhaled H2S predicted a non-eosinophilic phenotype in our study population. (C) 2015 Daedalus Enterprises

语种英语
WOS记录号WOS:000350898900015
项目编号81170012 ; 81370141 ; 201002008 ; 2013HXFB05
资助机构National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders grant
引用统计
被引频次:7[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66170
专题北京大学第三临床医学院_呼吸科
北京大学第三临床医学院_运动医学研究所
作者单位1.Peking Univ, Hosp 3, Dept Resp Dis, Beijing 100191, Peoples R China
2.Beijing Tongren Hosp, Dept Resp Dis, Beijing, Peoples R China
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GB/T 7714
Zhang, Jing,Wang, Xinmao,Chen, Yahong,et al. Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD[J]. RESPIRATORY CARE,2015,60(2):251-258.
APA Zhang, Jing,Wang, Xinmao,Chen, Yahong,&Yao, Wanzhen.(2015).Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD.RESPIRATORY CARE,60(2),251-258.
MLA Zhang, Jing,et al."Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD".RESPIRATORY CARE 60.2(2015):251-258.
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