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学科主题: 临床医学
题名:
Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD
作者: Zhang, Jing1; Wang, Xinmao2; Chen, Yahong1; Yao, Wanzhen1
关键词: chronic obstructive pulmonary disease ; airway inflammation phenotype ; eosinophilia ; hydrogen sulfide
刊名: RESPIRATORY CARE
发表日期: 2015-02-01
DOI: 10.4187/respcare.03519
卷: 60, 期:2, 页:251-258
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Critical Care Medicine ; Respiratory System
研究领域[WOS]: General & Internal Medicine ; Respiratory System
关键词[WOS]: OBSTRUCTIVE PULMONARY-DISEASE ; CHRONIC-BRONCHITIS ; SPUTUM-EOSINOPHILIA ; SODIUM SULFIDE ; ASTHMA ; EXACERBATIONS ; DYSPNEA ; HEALTHY ; GAS
英文摘要:

BACKGROUND: The role of exhaled H2S as a marker of airway inflammation and its relationship with COPD severity remain to be determined. METHODS: Airway inflammation was classified in 77 COPD subjects based on the presence of inflammatory cells in induced sputum. We investigated the association between disease phenotype and exhaled H2S, lung function, and plasma levels of several inflammatory factors, including tumor necrosis factor alpha, interleukin-8, and leukotriene B-4. RESULTS: In total, 33.77% of enrolled COPD subjects were diagnosed with eosinophilia. These subjects had a longer disease course, smoked fewer cigarettes, and experienced more frequent exacerbation events before study enrollment. However, they also had worse lung function and larger residual volume, they demonstrated greater changes in FEV1, following bronchodilator inhalation. Although levels of plasma inflammatory factors did not significantly differ between subjects with and without eosinophilia, subjects without eosinophilia had significantly higher levels of exhaled H2S (9.19 +/- 2.74 vs 7.24 +/- 1.68 parts per billion, P = .01). Furthermore, exhaled H2S levels were negatively correlated with induced sputum eosinophils (r = 0.45, P = .05), and positively correlated with inspiratory capacity in COPD subjects (r = 0.51, P = .026), but did not correlate significantly with plasma inflammatory factors. A cut-off value of 7.10 parts per billion of exhaled H2S predicted a non-eosinophilic phenotype with 68.6% sensitivity and 77.9% specificity. CONCLUSIONS: Exhaled levels of H2S were lower in subjects with eosinophilia. Increased levels of exhaled H2S predicted a non-eosinophilic phenotype in our study population. (C) 2015 Daedalus Enterprises

语种: 英语
所属项目编号: 81170012 ; 81370141 ; 201002008 ; 2013HXFB05
项目资助者: National Natural Science Foundation of China ; Research Special Fund for Public Welfare Industry of Health ; Beijing Key Laboratory of Respiratory and Pulmonary Circulation Disorders grant
WOS记录号: WOS:000350898900015
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66170
Appears in Collections:北京大学第三临床医学院_呼吸内科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Resp Dis, Beijing 100191, Peoples R China
2.Beijing Tongren Hosp, Dept Resp Dis, Beijing, Peoples R China

Recommended Citation:
Zhang, Jing,Wang, Xinmao,Chen, Yahong,et al. Exhaled Hydrogen Sulfide Predicts Airway Inflammation Phenotype in COPD[J]. RESPIRATORY CARE,2015,60(2):251-258.
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