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学科主题: 基础医学
题名:
TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats
作者: Simonic-Kocijan, Suncana1,2; Zhao, Xuehong1,3; Liu, Wen1; Wu, Yuwei4; Uhac, Ivone2; Wang, KeWei1,5,6
关键词: Hippocampus ; Masseter muscle ; TMD ; TRG ; TRPV1
刊名: MOLECULAR PAIN
发表日期: 2013-12-30
DOI: 10.1186/1744-8069-9-68
卷: 9, 期:1, 页:1-9
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Neurosciences
研究领域[WOS]: Neurosciences & Neurology
关键词[WOS]: TEMPOROMANDIBULAR DISORDERS ; MECHANICAL ALLODYNIA ; TISSUE INFLAMMATION ; NOXIOUS-STIMULATION ; TRANSITION ZONE ; OROFACIAL DEEP ; PAIN ; HYPERALGESIA ; ACTIVATION ; EXPRESSION
英文摘要:

Pain in masticatory muscles is among the most prominent symptoms of temperomandibular disorders (TMDs) that have diverse and complex etiology. A common complaint of TMD is that unilateral pain of craniofacial muscle can cause a widespread of bilateral pain sensation, although the underlying mechanism remains unknown. To investigate whether unilateral inflammation of masseter muscle can cause a bilateral allodynia, we generated masseter muscle inflammation induced by unilateral injection of complete Freund′s adjuvant (CFA) in rats, and measured the bilateral head withdrawal threshold at different time points using a von Frey anesthesiometer. After behavioral assessment, both right and left trigeminal ganglia (TRG) were dissected and examined for histopathology and transient receptor potential vanilloid 1 (TRPV1) mRNA expression using quantitative real-time PCR analysis. A significant increase in TRPV1 mRNA expression occurred in TRG ipsilateral to CFA injected masseter muscle, whereas no significant alteration in TRPV1 occurred in the contralateral TRG. Interestingly, central injection of TRPV1 antagonist 5-iodoresiniferatoxin into the hippocampus significantly attenuated the head withdrawal response of both CFA injected and non-CFA injected contralateral masseter muscle. Our findings show that unilateral inflammation of masseter muscle is capable of inducing bilateral allodynia in rats. Upregulation of TRPV1 at the TRG level is due to nociception caused by inflammation, whereas contralateral nocifensive behavior in masticatory muscle nociception is likely mediated by central TRPV1, pointing to the involvement of altered information processing in higher centers.

语种: 英语
所属项目编号: 2013CB531302 ; 30970919 ; 81221002 ; B07001
项目资助者: Ministry of Science and Technology of China ; National Science Foundation of China ; Ministry of Education of China, 111 Project China
WOS记录号: WOS:000330051800001
Citation statistics:
内容类型: 期刊论文
版本: 出版稿
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66172
Appears in Collections:基础医学院_神经生物学系_期刊论文

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作者单位: 1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Dept Neurobiol, Beijing 100871, Peoples R China
2.Rijeka Univ, Sch Dent Med, Fac Med, Dept Prosthodont, Rijeka 51000, Croatia
3.Hubei Univ Arts & Sci, Coll Med, Med Funct Dept, Xiangyang 441053, Peoples R China
4.Peking Univ, Sch Stomatol, Dent Ctr 2, Beijing 100191, Peoples R China
5.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
6.Peking Univ, McGovern Inst Brain Res, PKU IDG, Beijing 100871, Peoples R China

Recommended Citation:
Simonic-Kocijan, Suncana,Zhao, Xuehong,Liu, Wen,et al. TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats[J]. MOLECULAR PAIN,2013,9(1):1-9.
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