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学科主题基础医学
TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats
Simonic-Kocijan, Suncana1,2; Zhao, Xuehong1,3; Liu, Wen1; Wu, Yuwei4; Uhac, Ivone2; Wang, KeWei1,5,6
关键词Hippocampus Masseter muscle TMD TRG TRPV1
刊名MOLECULAR PAIN
2013-12-30
DOI10.1186/1744-8069-9-68
9期:1页:1-9
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Neurosciences
研究领域[WOS]Neurosciences & Neurology
关键词[WOS]TEMPOROMANDIBULAR DISORDERS ; MECHANICAL ALLODYNIA ; TISSUE INFLAMMATION ; NOXIOUS-STIMULATION ; TRANSITION ZONE ; OROFACIAL DEEP ; PAIN ; HYPERALGESIA ; ACTIVATION ; EXPRESSION
英文摘要

Pain in masticatory muscles is among the most prominent symptoms of temperomandibular disorders (TMDs) that have diverse and complex etiology. A common complaint of TMD is that unilateral pain of craniofacial muscle can cause a widespread of bilateral pain sensation, although the underlying mechanism remains unknown. To investigate whether unilateral inflammation of masseter muscle can cause a bilateral allodynia, we generated masseter muscle inflammation induced by unilateral injection of complete Freund′s adjuvant (CFA) in rats, and measured the bilateral head withdrawal threshold at different time points using a von Frey anesthesiometer. After behavioral assessment, both right and left trigeminal ganglia (TRG) were dissected and examined for histopathology and transient receptor potential vanilloid 1 (TRPV1) mRNA expression using quantitative real-time PCR analysis. A significant increase in TRPV1 mRNA expression occurred in TRG ipsilateral to CFA injected masseter muscle, whereas no significant alteration in TRPV1 occurred in the contralateral TRG. Interestingly, central injection of TRPV1 antagonist 5-iodoresiniferatoxin into the hippocampus significantly attenuated the head withdrawal response of both CFA injected and non-CFA injected contralateral masseter muscle. Our findings show that unilateral inflammation of masseter muscle is capable of inducing bilateral allodynia in rats. Upregulation of TRPV1 at the TRG level is due to nociception caused by inflammation, whereas contralateral nocifensive behavior in masticatory muscle nociception is likely mediated by central TRPV1, pointing to the involvement of altered information processing in higher centers.

语种英语
WOS记录号WOS:000330051800001
项目编号2013CB531302 ; 30970919 ; 81221002 ; B07001
资助机构Ministry of Science and Technology of China ; National Science Foundation of China ; Ministry of Education of China, 111 Project China
引用统计
被引频次:10[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
版本出版稿
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66172
专题北京大学基础医学院_神经生物学系
北京大学药学院_分子与细胞药理学系
北京大学口腔医学院_第二门诊部
作者单位1.Peking Univ, Hlth Sci Ctr, Neurosci Res Inst, Dept Neurobiol, Beijing 100871, Peoples R China
2.Rijeka Univ, Sch Dent Med, Fac Med, Dept Prosthodont, Rijeka 51000, Croatia
3.Hubei Univ Arts & Sci, Coll Med, Med Funct Dept, Xiangyang 441053, Peoples R China
4.Peking Univ, Sch Stomatol, Dent Ctr 2, Beijing 100191, Peoples R China
5.Peking Univ, Sch Pharmaceut Sci, Dept Mol & Cellular Pharmacol, Beijing 100191, Peoples R China
6.Peking Univ, McGovern Inst Brain Res, PKU IDG, Beijing 100871, Peoples R China
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GB/T 7714
Simonic-Kocijan, Suncana,Zhao, Xuehong,Liu, Wen,et al. TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats[J]. MOLECULAR PAIN,2013,9(1):1-9.
APA Simonic-Kocijan, Suncana,Zhao, Xuehong,Liu, Wen,Wu, Yuwei,Uhac, Ivone,&Wang, KeWei.(2013).TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats.MOLECULAR PAIN,9(1),1-9.
MLA Simonic-Kocijan, Suncana,et al."TRPV1 channel-mediated bilateral allodynia induced by unilateral masseter muscle inflammation in rats".MOLECULAR PAIN 9.1(2013):1-9.
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