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学科主题: 临床医学
题名:
Age-Specific Cutoff Value for the Application of Percent Free Prostate-Specific Antigen (PSA) in Chinese Men with Serum PSA Levels of 4.0-10.0 ng/ml
作者: Chen, Rui1; Huang, Yiran2; Cai, Xiaobing3; Xie, Liping4; He, Dalin5; Zhou, Liqun6; Xu, Chuanliang1; Gao, Xu1; Ren, Shancheng1; Wang, Fubo1; Ma, Lulin7; Wei, Qiang8; Yin, Changjun9,10; Tian, Ye11; Sun, Zhongquan12; Fu, Qiang13; Ding, Qiang14; Zheng, Junhua15; Ye, Zhangqun16; Ye, Dingwei17,18; Xu, Danfeng19; Hou, Jianquan20; Xu, Kexin21; Yuan, Jianlin22; Gao, Xin23; Liu, Chunxiao24; Pan, Tiejun25; Sun, Yinghao1; Chinese Prostate Canc Consortium
刊名: PLOS ONE
发表日期: 2015-06-19
DOI: 10.1371/journal.pone.0130308
卷: 10, 期:6
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Multidisciplinary Sciences
研究领域[WOS]: Science & Technology - Other Topics
关键词[WOS]: MULTICENTER CLINICAL-TRIAL ; COMMUNITY-BASED POPULATION ; GENOME-WIDE ASSOCIATION ; CANCER STATISTICS ; REFERENCE RANGES ; WHITE MEN ; BIOPSY ; RATES ; RISK
英文摘要:

Objective

The influence of age on the performance of percent free prostate-specific antigen (%fPSA) in diagnosing prostate cancer (PCa) in East Asians is controversial. We tested the diagnostic performance of %fPSA in a multi-center biopsy cohort in China and identified the proper age-specific cutoff values to avoid unnecessary biopsies.

Methods

Consecutive patients with a prostate-specific antigen (PSA) level of 4.0-10.0 ng/ml or 10.1-20.0 ng/ml who underwent transrectal ultrasound-guided or transperineal prostate biopsy were enrolled from 22 Chinese medical centers from Jan 1, 2010 to Dec 31, 2013. The diagnostic accuracy of PSA and %fPSA was determined using the area under the receiver operating characteristic (ROC) curve (AUC). Age-specific cutoff values were calculated using ROC curve analysis.

Results

The median %fPSA was much lower in younger patients compared with older patients with a PSA level of 4.0-10.0 ng/ml or 10.1-20.0 ng/ml. The AUC of %fPSA was higher than PSA only in older patients. In patients aged 50 to 59 years, %fPSA failed to improve the diagnosis compared with PSA in these two PSA ranges. Age-specific cutoff values were 24%, 27% and 32% for patients aged 60-69, 70-79 and >= 80 years, respectively, to reduce unnecessary biopsies in men with PSA levels of 4.0-10.0 ng/ml to detect 90% of all PCa.

Conclusions

The effectiveness of %fPSA is correlated with age in the Chinese population. Age-specific cutoff values would help avoid unnecessary biopsies in the Chinese population.

语种: 英语
所属项目编号: IRT1111 ; 2012CB518300 ; 2012CB518306
项目资助者: Program for Changjiang Scholars and Innovative Research Team in University scheme of the Ministry of Education of China ; National Basic Research Program of China
WOS记录号: WOS:000356835000101
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66177
Appears in Collections:北京大学第一临床医学院_泌尿外科_期刊论文

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作者单位: 1.Peking Univ, Hosp 3, Dept Urol, Beijing, Peoples R China
2.Second Mil Med Univ, Shanghai Changhai Hosp, Dept Urol, Shanghai 200433, Peoples R China
3.Shanghai Jiao Tong Univ, Renji Hosp, Sch Med, Shanghai 200127, Peoples R China
4.PLA Headquarters Gen Staff Guard Bur, Dept Hlth Care, Beijing 100017, Peoples R China
5.Zhejiang Univ, Affiliated Hosp 1, Sch Med, Dept Urol, Hangzhou 310003, Zhejiang, Peoples R China
6.Xi An Jiao Tong Univ, Affiliated Hosp 1, Sch Med, Dept Urol, Xian 710061, Peoples R China
7.Peking Univ, Hosp 1, Natl Urol Canc Ctr, Inst Urol,Dept Urol, Beijing 100034, Peoples R China
8.Sichuan Univ, West China Hosp, Dept Urol, Chengdu, Sichuan, Peoples R China
9.Nanjing Med Univ, Affiliated Hosp 1, State Key Lab Reprod Med, Nanjing, Jiangsu, Peoples R China
10.Nanjing Med Univ, Affiliated Hosp 1, Dept Urol, Nanjing, Jiangsu, Peoples R China
11.Capital Med Univ, Beijing Friendship Hosp, Dept Urol, Beijing 100050, Peoples R China
12.Fudan Univ, Huadong Hosp, Dept Urol, Shanghai 20040, Peoples R China
13.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200030, Peoples R China
14.Fudan Univ, Huashan Hosp, Shanghai 200040, Peoples R China
15.Tongji Univ, Peoples Hosp 10, Dept Urol, Shanghai 200092, Peoples R China
16.Huazhong Univ Sci & Technol, Tongji Hosp, Tongji Med Coll, Dept Urol, Wuhan 430030, Peoples R China
17.Fudan Univ, Shanghai Canc Ctr, Shanghai 200032, Peoples R China
18.Dept Oncol, Shanghai 200032, Peoples R China
19.Second Mil Med Univ, Shanghai Changzheng Hosp, Dept Urol, Shanghai 200433, Peoples R China
20.Soochow Univ, Affiliated Hosp 1, Suzhou 215006, Peoples R China
21.Peking Univ, Peoples Hosp, Beijing 100044, Peoples R China
22.Fourth Mil Med Univ, Dept Urol, Xian 710032, Peoples R China
23.Sun Yat Sen Univ, Hosp 3, Dept Urol, Guangzhou 510630, Guangdong, Peoples R China
24.Southern Med Univ, Zhujiang Hosp, Dept Urol, Guangzhou 510282, Guangdong, Peoples R China
25.Wuhan Gen Hosp, Guangzhou Mil Command, Dept Urol, Wuhan 430070, Hubei, Peoples R China

Recommended Citation:
Chen, Rui,Huang, Yiran,Cai, Xiaobing,et al. Age-Specific Cutoff Value for the Application of Percent Free Prostate-Specific Antigen (PSA) in Chinese Men with Serum PSA Levels of 4.0-10.0 ng/ml[J]. PLOS ONE,2015,10(6).
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