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学科主题: 临床医学
题名:
A clinical, neurolinguistic, and radiological study of a Chinese follow-up case with primary progressive aphasia
作者: Zhou, Jiong1; Wang, Jian-An2; Jiang, Biao3; Qiu, Wen-Juan4; Yan, Bin4; Wang, Yin-Hua5
关键词: Primary progressive aphasia ; Neurolinguistic ; Magnetic resonance imaging ; Chinese aphasia
刊名: NEUROCASE
发表日期: 2013-10-01
DOI: 10.1080/13554794.2012.690426
卷: 19, 期:5, 页:427-433
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology ; Social Sciences
类目[WOS]: Clinical Neurology ; Psychiatry ; Psychology
研究领域[WOS]: Neurosciences & Neurology ; Psychiatry ; Psychology
关键词[WOS]: DEMENTIA
英文摘要:

Primary progressive aphasia (PPA) is a progressive neurodegenerative disorder characterized by the deterioration of language functions. The Han language bears some unique features from the Latin languages; however, the features of PPA in the Han language-speaking population are not well understood. In this study, we performed a 3-year follow-up on a Han language-speaking PPA patient with corresponding changes in magnetic resonance imaging (MRI). During the early stage, linguistic analysis revealed several symptoms including difficulty with auditory comprehension, right-left disorientation, reading disorders, and agraphia, specifically the execution of serial oral instructions. This Chinese PPA patient presented with a reading disorder, but his word comprehension ability remained intact. There are two different possible modalities of incorrect writing in this case. The patient also presented with noun-verb double dissociation. The early-stage MRI showed atrophy of the left frontal lobe, which was most severe in the inferior frontal gyrus. Three years later, the patient was found to have progressive atrophy in the parietal, frontal, and temporal lobes, among which the frontal lobe remained the most severely affected region. The brain imaging of the Chinese-speaking PPA patient showed changes similar to those of a Latin language-speaking PPA patient. The prominent change was asymmetrical atrophy in the frontal and temporal lobes. This is the first report of noun-verb double dissociation existing in a Chinese-language speaking PPA patient. The dissociation may be related to an impaired function of the inferior frontal gyrus, which is likely associated with verb-naming in Chinese-speaking people. Several unique features were observed in this case, including impairment in writing ability.

语种: 英语
WOS记录号: WOS:000324977600003
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66182
Appears in Collections:北京大学第一临床医学院_神经内科_期刊论文

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作者单位: 1.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Neurol, Hangzhou 310003, Zhejiang, Peoples R China
2.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Cardiol, Hangzhou 310003, Zhejiang, Peoples R China
3.Zhejiang Univ, Sch Med, Affiliated Hosp 2, Dept Radiol, Hangzhou 310003, Zhejiang, Peoples R China
4.China Natl Digital Switching Syst Engn & Technol, Zhengzhou, Peoples R China
5.Peking Univ, Sch Med, Affiliated Hosp 1, Dept Neurol, Beijing 100871, Peoples R China

Recommended Citation:
Zhou, Jiong,Wang, Jian-An,Jiang, Biao,et al. A clinical, neurolinguistic, and radiological study of a Chinese follow-up case with primary progressive aphasia[J]. NEUROCASE,2013,19(5):427-433.
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