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学科主题: 临床医学
题名:
Albuminuria: Prevalence, associated risk factors and relationship with cardiovascular disease
作者: Chen, Fang1; Yang, Wenying2; Weng, Jianping6; Jia, Weiping7; Ji, Linong3; Xiao, Jianzhong2; Shan, Zhongyan8; Liu, Jie9; Tian, Haoming10; Ji, Qiuhe11; Zhu, Dalong12; Ge, Jiapu13; Lin, Lixiang14; Chen, Li15; Guo, Xiaohui4; Zhao, Zhigang16; Li, Qiang17; Zhou, Zhiguang18; Shan, Guangliang5; Lu, Juming1; China Natl Diabet Metab Disorders
关键词: Albuminuria ; Diabetes mellitus ; Cardiovascular disease
刊名: JOURNAL OF DIABETES INVESTIGATION
发表日期: 2014-07-01
DOI: 10.1111/jdi.12172
卷: 5, 期:4, 页:464-471
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Endocrinology & Metabolism
研究领域[WOS]: Endocrinology & Metabolism
关键词[WOS]: CHRONIC KIDNEY-DISEASE ; NUTRITION EXAMINATION SURVEY ; STAGE RENAL-DISEASE ; METABOLIC SYNDROME ; GENERAL-POPULATION ; COST-EFFECTIVENESS ; NATIONAL-HEALTH ; URINE ALBUMIN ; INDIVIDUALS ; MORTALITY
英文摘要:

Aims/Introduction: To investigate the prevalence and associated risk factors of microalbuminuria, and to explore the relationship between albuminuria and cardiovascular disease (CVD).

Materials and Methods: A nationally representative sample of 38,203 Chinese participants was categorized by different levels of urinary albumin-to-creatinine ratio (ACR; 0-10 mg/g, 10-20 mg/g, 20-30 mg/g, 30-300 mg/g). The prevalence of albuminuria was compared by using a single urinary ACR cut-off point and by sex-specific ACR cut-off points. Factors associated with the presence of albuminuria, and the relationship between albuminuria and CVD were analyzed by logistic regression.

Results: Prevalence of albuminuria as measured by a single ACR cut-point was significantly lower for men compared with women (13.9% vs 19.1% in the normal glucose tolerance group; 20.8% vs 26.8% in the impaired glucose tolerance group, P < 0.01). The prevalence of albuminuria, as measured by sex-specific ACR cut-points, was higher for men than women (31.4% vs 29.6% in the normal glucose tolerance group; 42.2% vs 39.3% in the impaired glucose tolerance group, P < 0.01). The independent risk factors for the presence of albuminuria were aging, female sex, hypertension, hyperglycemia, obesity, dyslipidemia, insulin resistance and metabolic syndrome. The subdivided normal ACR group did not show a linear or statistically significant relationship with CVD after adjusting for conventional CVD risk factors (P > 0.05).

Conclusions: The prevalence of albuminuria was high in the general Chinese population. Aging, female sex, hypertension, hyperglycemia, dyslipidemia, insulin resistance, obesity and metabolic syndrome were all independent risk factors for albuminuria. The causal relationship between ACR and CVD might require further follow-up investigation.

语种: 英语
项目资助者: Chinese Medical Association Foundation ; Chinese Diabetes Society
WOS记录号: WOS:000339495600017
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66184
Appears in Collections:北京大学第二临床医学院_期刊论文

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作者单位: 1.Henan Prov Peoples Hosp, Zhengzhou, Henan, Peoples R China
2.Xiangya Second Hosp, Changsha, Hunan, Peoples R China
3.Chinese Peoples Liberat Army Gen Hosp, Dept Endocrinol & Metab, Beijing, Peoples R China
4.China Japan Friendship Hosp, Beijing, Peoples R China
5.Peking Univ, Peoples Hosp, Beijing 100871, Peoples R China
6.Peking Univ, Hosp 1, Beijing 100871, Peoples R China
7.Chinese Acad Med Sci, Inst Basic Med Sci, Sch Basic Med, Dept Epidemiol & Stat,Peking Union Med Coll, Beijing 100730, Peoples R China
8.Sun Yat Sen Univ, Hosp 3, Guangzhou 510275, Guangdong, Peoples R China
9.Shanghai Jiao Tong Univ, Affiliated Peoples Hosp 6, Shanghai 200030, Peoples R China
10.Chinese Med Univ, Affiliated Hosp 1, Shenyang, Liaoning, Peoples R China
11.Shanxi Prov Peoples Hosp, Taiyuan, Shanxi, Peoples R China
12.Xinjiang Uygur Autonomous Reg Hosp, Urumqi, Xinjiang, Peoples R China
13.Fujian Prov Hosp, Fuzhou, Fujiang, Peoples R China
14.Sichuan Univ, West China Hosp, Chengdu 610064, Sichuan, Peoples R China
15.Fourth Mil Med Univ, Xijing Hosp, Xian 710032, Shaanxi, Peoples R China
16.Nanjing Univ, Sch Med, Affiliated Drum Tower Hosp, Nanjing 210008, Jiangsu, Peoples R China
17.Shandong Univ, Qilu Hosp, Jinan 250100, Shandong, Peoples R China
18.Harbin Med Univ, Affiliated Hosp 2, Harbin, Heilongjiang, Peoples R China

Recommended Citation:
Chen, Fang,Yang, Wenying,Weng, Jianping,et al. Albuminuria: Prevalence, associated risk factors and relationship with cardiovascular disease[J]. JOURNAL OF DIABETES INVESTIGATION,2014,5(4):464-471.
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