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学科主题: 临床医学
题名:
Assessment of Clinical Effect of Therapy Combining Disease with Syndrome on Rheumatoid Arthritis
作者: Shen Hong-bo1; Bai Yun-jing2; Huo Ze-jun1; Li Wei-nong3; Tang Xian-ping3
关键词: combination of disease with syndrome ; rheumatoid arthritis ; syndrome of damp-heat obstruction
刊名: JOURNAL OF TRADITIONAL CHINESE MEDICINE
发表日期: 2011-03-01
卷: 31, 期:1, 页:39-43
收录类别: SCI
文章类型: Article
WOS标题词: Science & Technology
类目[WOS]: Integrative & Complementary Medicine
研究领域[WOS]: Integrative & Complementary Medicine
英文摘要:

Objective: To observe the effectiveness and safety of a therapy combining disease with syndrome on rheumatoid arthritis.

Methods: Eighty patients with rheumatoid arthritis belonging to syndrome of damp-heat obstruction were randomly divided into a treatment group and a control group according to stratified blocked randomization method.Forty cases in the control group orally took Loxoprofen Sodium Tablet and Leifumite Tablet and the other 40 cases in the treatment group orally took a Chinese medicine for 12 weeks as a course of treatment. ACR therapeutic effect was used as the standard for evaluating the total therapeutic effect.

Results: After 12 weeks of treatment, there was a statistical difference (P < 0.01) in the improvement of VAS score, morning stiffness time, number of swelling joints, index of swelling joints, number of joints with tenderness, index of joints with tenderness, average grip strength of both hands, DSA28 score, HAQ, patient′s assessment, physician′s assessment, ESR, CRP and RF in both groups. The improvement of morning stiffness time, number of swelling joints, index of swelling joints, grip strength, HAQ and patient′s assessment in the treatment group was much better than that in the control groups with statistical difference (P < 0.05). ACR20, ACR50 and ACR70 was 27.5% (11/40), 37.5% (15/40) and 22.5% (9/40) respectively in the treatment group and 40% (16/40), 27.5% (11/42) and 10.0% (4/40) respectively in the control group with statistical difference (P < 0.05) in the superiority of the treatment group over the control group. The incidence of adverse reaction in the control group was higher than that in the treatment group (P < 0.05).

Conclusion: Definite therapeutic effect and high safety can be achieved in using the therapy combining disease with syndrome to treat rheumatoid arthritis belonging to syndrome of damp-heat obstruction.

语种: 英语
所属项目编号: 04-05LP45
项目资助者: Specialized Research Fund for TCM Science and Technology of State Administration of TCM of China ; Third Hospital of Beijing University of China
WOS记录号: WOS:000288236600009
Citation statistics:
内容类型: 期刊论文
URI标识: http://ir.bjmu.edu.cn/handle/400002259/66186
Appears in Collections:北京大学第三临床医学院_期刊论文

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作者单位: 1.Beijing Univ, Hosp 3, Beijing 100191, Peoples R China
2.Beijing Mil Gen Hosp, Beijing 100700, Peoples R China
3.China Acad Tradit Chinese Med Sci, Wangjing Hosp, Beijing 100102, Peoples R China

Recommended Citation:
Shen Hong-bo,Bai Yun-jing,Huo Ze-jun,et al. Assessment of Clinical Effect of Therapy Combining Disease with Syndrome on Rheumatoid Arthritis[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2011,31(1):39-43.
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