IR@PKUHSC  > 北京大学第三临床医学院
学科主题临床医学
Assessment of Clinical Effect of Therapy Combining Disease with Syndrome on Rheumatoid Arthritis
Shen Hong-bo1; Bai Yun-jing2; Huo Ze-jun1; Li Wei-nong3; Tang Xian-ping3
关键词combination of disease with syndrome rheumatoid arthritis syndrome of damp-heat obstruction
刊名JOURNAL OF TRADITIONAL CHINESE MEDICINE
2011-03-01
31期:1页:39-43
收录类别SCI
文章类型Article
WOS标题词Science & Technology
类目[WOS]Integrative & Complementary Medicine
研究领域[WOS]Integrative & Complementary Medicine
英文摘要

Objective: To observe the effectiveness and safety of a therapy combining disease with syndrome on rheumatoid arthritis.

Methods: Eighty patients with rheumatoid arthritis belonging to syndrome of damp-heat obstruction were randomly divided into a treatment group and a control group according to stratified blocked randomization method.Forty cases in the control group orally took Loxoprofen Sodium Tablet and Leifumite Tablet and the other 40 cases in the treatment group orally took a Chinese medicine for 12 weeks as a course of treatment. ACR therapeutic effect was used as the standard for evaluating the total therapeutic effect.

Results: After 12 weeks of treatment, there was a statistical difference (P < 0.01) in the improvement of VAS score, morning stiffness time, number of swelling joints, index of swelling joints, number of joints with tenderness, index of joints with tenderness, average grip strength of both hands, DSA28 score, HAQ, patient′s assessment, physician′s assessment, ESR, CRP and RF in both groups. The improvement of morning stiffness time, number of swelling joints, index of swelling joints, grip strength, HAQ and patient′s assessment in the treatment group was much better than that in the control groups with statistical difference (P < 0.05). ACR20, ACR50 and ACR70 was 27.5% (11/40), 37.5% (15/40) and 22.5% (9/40) respectively in the treatment group and 40% (16/40), 27.5% (11/42) and 10.0% (4/40) respectively in the control group with statistical difference (P < 0.05) in the superiority of the treatment group over the control group. The incidence of adverse reaction in the control group was higher than that in the treatment group (P < 0.05).

Conclusion: Definite therapeutic effect and high safety can be achieved in using the therapy combining disease with syndrome to treat rheumatoid arthritis belonging to syndrome of damp-heat obstruction.

语种英语
WOS记录号WOS:000288236600009
项目编号04-05LP45
资助机构Specialized Research Fund for TCM Science and Technology of State Administration of TCM of China ; Third Hospital of Beijing University of China
引用统计
被引频次:6[WOS]   [WOS记录]     [WOS相关记录]
文献类型期刊论文
条目标识符http://ir.bjmu.edu.cn/handle/400002259/66186
专题北京大学第三临床医学院
北京大学第三临床医学院_中医科
作者单位1.Beijing Univ, Hosp 3, Beijing 100191, Peoples R China
2.Beijing Mil Gen Hosp, Beijing 100700, Peoples R China
3.China Acad Tradit Chinese Med Sci, Wangjing Hosp, Beijing 100102, Peoples R China
推荐引用方式
GB/T 7714
Shen Hong-bo,Bai Yun-jing,Huo Ze-jun,et al. Assessment of Clinical Effect of Therapy Combining Disease with Syndrome on Rheumatoid Arthritis[J]. JOURNAL OF TRADITIONAL CHINESE MEDICINE,2011,31(1):39-43.
APA Shen Hong-bo,Bai Yun-jing,Huo Ze-jun,Li Wei-nong,&Tang Xian-ping.(2011).Assessment of Clinical Effect of Therapy Combining Disease with Syndrome on Rheumatoid Arthritis.JOURNAL OF TRADITIONAL CHINESE MEDICINE,31(1),39-43.
MLA Shen Hong-bo,et al."Assessment of Clinical Effect of Therapy Combining Disease with Syndrome on Rheumatoid Arthritis".JOURNAL OF TRADITIONAL CHINESE MEDICINE 31.1(2011):39-43.
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